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Erschienen in:

21.06.2021 | Behavioral-Bio-Medical Interface (RJ DiClemente and JL Brown, Section Editors)

A Review of Interventions to Enhance HIV Medication Adherence

verfasst von: Laura B. Whiteley, Elizabeth M. Olsen, Kayla K. Haubrick, Enyonam Odoom, Nicholas Tarantino, Larry K. Brown

Erschienen in: Current HIV/AIDS Reports | Ausgabe 5/2021

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Abstract

Purpose of Review

Adherence to antiretroviral treatment (ART) is crucial for the successful treatment of HIV. Unfortunately, it is estimated that 45% of persons living with HIV (PLWH) have poor adherence to ART. To provide health care professionals and PLWH with effective tools for supporting adherence, researchers have investigated the effectiveness of psychosocial interventions to enhance adherence to ART. In this paper, interventional studies, systematic reviews, and meta-analyses that examine ART adherence interventions for PLWH are reviewed.

Recent Findings

There is great variability among interventions in terms of quality, sample, measures, and outcome characteristics. Despite a diverse and wide-ranging assortment of ART adherence interventions, consistent lessons have been learned. Interventions that focus on individual and interpersonal factors have been effective for improving ART adherence; however, the improvement in adherence tends to be short-lived. Additionally, interventions are most successful when tailored to those at risk for poor adherence. Finally, theory-based interventions are more likely to be effective than non-theory-based interventions.

Summary

A variety of individual-level psychological interventions have been shown to be effective in improving ART adherence in the short term. Digital and mobile interventions have the potential to improve dissemination and implementation of these evidence-based interventions and could be used to extend intervention effects. Future interventions that address issues of accessibility, inequality, structural and institutional barriers to ART adherence should also be tested and prioritized. Implementation science frameworks can be used to assess and address issues of accessibility and systematic barriers to care.

Howard AA, Arnsten JH, Lo Y, Vlahov D, Rich JD, Schuman P, et al. A prospective study of adherence and viral load in a large multi-center cohort of HIV-infected women. AIDS England. 2002;16:2175–82.

Knobel H, Alonso J, Casado JL, Collazos J, González J, Ruiz I, et al. Validation of a simplified medication adherence questionnaire in a large cohort of HIV-infected patients: the GEEMA Study. AIDS England. 2002;16:605–13.

Knobel H, Guelar A, Carmona A, Espona M, González A, López-Colomés JL, et al. Virologic outcome and predictors of virologic failure of highly active antiretroviral therapy containing protease inhibitors. AIDS Patient Care STDS United States. 2001;15:193–9.

Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med United States. 2000;133:21–30.

Langebeek N, Gisolf EH, Reiss P, Vervoort SC, Hafsteinsdóttir TB, Richter C, et al. Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis. BMC Med. 2014. https://doi.org/10.1186/s12916-014-0142-1.

Benson C, Wang X, Dunn KJ, Li N, Mesana L, Lai J, et al. Antiretroviral adherence, drug resistance, and the impact of social determinants of health in HIV-1 patients in the US. AIDS Behav. 2020;24:3562–73. https://doi.org/10.1007/s10461-020-02937-8.CrossRefPubMed

Centers for Disease Control and Prevention (CDC). Vital signs: HIV prevention through care and treatment--United States. [Internet]. MMWR. Morb. Mortal. Wkly. Rep. 2011. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22129997

World Health Organization. Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. WHO Guidel. 2014;

Mugavero MJ, Amico KR, Horn T, Thompson MA. The state of engagement in HIV care in the United States: from cascade to continuum to control. Clin Infect Dis an Off Publ Infect Dis Soc Am. United States. 2013;57:1164–71.

10.

Byrd KK, Hou JG, Hazen R, Kirkham H, Suzuki S, Clay PG, et al. antiretroviral adherence level necessary for HIV viral suppression using real-world data. J Acquir Immune Defic Syndr. 2019;82:245–51.PubMedPubMedCentral

11.

Cavaleri MA, Kalogerogiannis K, Mckay MM, Vitale L, Levi E, Jones S, et al. Barriers to HIV care: an exploration of the complexities that influence engagement in and utilization of treatment. Soc Work Health Care. 2010;49:934–45. https://doi.org/10.1080/00981389.2010.514563.CrossRefPubMed

12.

Metsch LR, Pereyra M, Messinger S, Del Rio C, Strathdee SA, Anderson-Mahoney P, et al. HIV transmission risk behaviors among HIV-infected persons who are successfully linked to care. Clin Infect Dis an Off Publ Infect Dis Soc Am. United States. 2008;47:577–84.

13.

Mannheimer S, Friedland G, Matts J, Child C, Chesney M. The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clin Infect Dis an Off Publ Infect Dis Soc Am. United States. 2002;34:1115–21.

14.

Golin CE, Liu H, Hays RD, Miller LG, Beck CK, Ickovics J, et al. A prospective study of predictors of adherence to combination antiretroviral medication. J Gen Intern Med. 2002;17:756–65.PubMedPubMedCentral

15.

Moss AR, Hahn JA, Perry S, Charlebois ED, Guzman D, Clark RA, et al. Adherence to highly active antiretroviral therapy in the homeless population in San Francisco: a prospective study. Clin Infect Dis an Off Publ Infect Dis Soc Am. United States. 2004;39:1190–8.

16.

Thrasher AD, Earp JAL, Golin CE, Zimmer CR. Discrimination, distrust, and racial/ethnic disparities in antiretroviral therapy adherence among a national sample of HIV-infected patients. J Acquir Immune Defic Syndr. United States. 2008;49:84–93.

17.

Simoni JM, Huh D, Wilson IB, Shen J, Goggin K, Reynolds NR, et al. Racial/Ethnic disparities in ART adherence in the United States: findings from the MACH14 study. J Acquir Immune Defic Syndr. 2012;60:466–72.PubMedPubMedCentral

18.

Kyser M, Buchacz K, Bush TJ, Conley LJ, Hammer J, Henry K, et al. Factors associated with non-adherence to antiretroviral therapy in the SUN study. AIDS Care England. 2011;23:601–11.

19.

England MJ, Butler AS, Gonzalez ML, editors. Psychosocial interventions for mental and substance use disorders: a framework for establishing evidence-based standards. Washington (DC); 2015.

20.

World Health Organization. Withdrawal Management. Clin guidel withdrawal manag treat drug depend closed settings. 2009.

21.

Adefolalu AO. Cognitive-behavioural theories and adherence: application and relevance in antiretroviral therapy. South Afr J HIV Med. 2018;19.

22.

Amico KR, Barta W, Konkle-Parker DJ, Fisher JD, Cornman DH, Shuper PA, et al. The information-motivation-behavioral skills model of ART adherence in a deep south HIV+ clinic sample. AIDS Behav. 2009;

23.

Whiteley L, Brown LK, Mena L, Craker L, Arnold T. Enhancing health among youth living with HIV using an iPhone game. AIDS Care - Psychol Socio-Medical Asp AIDS/HIV. 2018;30.

24.

Golin CE, Earp J, Tien H-C, Stewart P, Porter C, Howie L. A 2-arm, randomized, controlled trial of a motivational interviewing-based intervention to improve adherence to antiretroviral therapy (ART) among patients failing or initiating ART. JAIDS J Acquir Immune Defic Syndr [Internet]. 2006;42. Available from: https://journals.lww.com/jaids/Fulltext/2006/05000/A_2_Arm,_Randomized,_Controlled_Trial_of_a.6.aspx

25.

Cunningham WE, Weiss RE, Nakazono T, Malek MA, Shoptaw SJ, Ettner SL, et al. Effectiveness of a peer navigation intervention to sustain viral suppression among HIV-positive men and transgender women released from jail: the LINK LA randomized clinical trial. JAMA Intern Med. 2018;178:542–53.PubMedPubMedCentral

26.

Pagan-Ortiz ME, Goulet P, Kogelman L, Levkoff SE, Weitzman PF. Feasibility of a texting intervention to improve medication adherence among older HIV+ African Americans: A mixed-method pilot study. Gerontol Geriatr Med. 2019;5:2333721419855662.PubMedPubMedCentral

27.

Tanner AE, Mann L, Song E, Alonzo J, Schafer K, Arellano E, et al. Wecare: A social media–based intervention designed to increase HIV care linkage, retention, and health outcomes for racially and ethnically diverse young MSM. AIDS Educ Prev. 2016;

28.

Garofalo R, Kuhns LM, Hotton A, Johnson A, Muldoon A, Rice D. A randomized controlled trial of personalized text message reminders to promote medication adherence among HIV-positive adolescents and young adults. AIDS Behav. 2016;

29.

Hightow-Weidman L, Muessig K, Knudtson K, Srivatsa M, Lawrence E, LeGrand S, et al. A gamified smartphone app to support engagement in care and medication adherence for HIV-positive young men who have sex with men (AllyQuest): development and pilot study. J Med Internet Res. 2018.

30.

Bandura A. Health promotion by social cognitive means. Heal Educ Behav Off Publ Soc Public Heal Educ. United States. 2004;31:143–64.

31.

Folkman S. Personal control and stress and coping processes: a theoretical analysis. J Pers Soc Psychol. 1984;46:839–52.PubMed

32.

Bova C, Burwick TN, Quinones M. Improving women’s adjustment to HIV infection: results of the Positive Life Skills Workshop Project. J Assoc Nurses AIDS Care. United States. 2008;19:58–65.

33.

Johnson MO, Dilworth SE, Taylor JM, Neilands TB. Improving Coping Skills for Self-management of treatment side effects can reduce antiretroviral medication nonadherence among people living with HIV. Ann Behav Med. 2011;41:83–91. https://doi.org/10.1007/s12160-010-9230-4.CrossRefPubMed

34.

Cummins J. Negotiating identities: education for empowerment in a diverse society. Ontario, Canada: California Association of Bilingual Education; 2001.

35.

Wagner GJ, Kanouse DE, Golinelli D, Miller LG, Daar ES, Witt MD, et al. Cognitive-behavioral intervention to enhance adherence to antiretroviral therapy: a randomized controlled trial (CCTG 578). AIDS [Internet]. 2006;20. Available from: https://journals.lww.com/aidsonline/Fulltext/2006/06120/Cognitive_behavioral_intervention_to_enhance.11.aspx

36.

Holstad MMD, DiIorio C, Magowe MKM. Motivating HIV positive women to adhere to antiretroviral therapy and risk reduction behavior: The KHARMA Project. Online J Issues Nurs. 2006.

37.

de Bruin M, Hospers HJ, van Breukelen GJP, Kok G, Koevoets WM, Prins JM. Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: a randomized controlled trial. Health Psychol. 2010.

38.

Linde DS, Korsholm M, Katanga J, Rasch V, Lundh A, Andersen MS. One-way SMS and healthcare outcomes in Africa: systematic review of randomised trials with meta-analysis. PLoS One. 2019;14:e0217485. https://doi.org/10.1371/journal.pone.0217485.CrossRefPubMedPubMedCentral

39.

Sabin LL, Bachman DeSilva M, Gill CJ, Zhong L, Vian T, Xie W, et al. Improving adherence to antiretroviral therapy with triggered real-time text message reminders: the China adherence through technology study. J Acquir Immune Defic Syndr. 2015;69:551–9.PubMedPubMedCentral

40.

Holstad MM, DiIorio C, Kelley ME, Resnicow K, Sharma S. Group motivational interviewing to promote adherence to antiretroviral medications and risk reduction behaviors in HIV infected women. AIDS Behav. 2011;15:885–96. https://doi.org/10.1007/s10461-010-9865-y.CrossRefPubMedPubMedCentral

41.

Bouris A, Jaffe K, Eavou R, Liao C, Kuhns L, Voisin D, et al. Project nGage: results of a randomized controlled trial of a dyadic network support intervention to retain young black men who have sex with men in HIV care. AIDS Behav [Internet]. 2017;21:3618–29. Available from: https://pubmed.ncbi.nlm.nih.gov/29079949

42.

Naar-King S, Outlaw AY, Sarr M, Parsons JT, Belzer M, Macdonell K, et al. Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment. J Pediatr Psychol. 2013;38:638–48.PubMedPubMedCentral

43.

Shegog R, Markham CM, Leonard AD, Bui TC, Paul ME. “+CLICK”: pilot of a web-based training program to enhance ART adherence among HIV-positive youth. AIDS Care. Taylor & Francis. 2012;24:310–8. https://doi.org/10.1080/09540121.2011.608788.CrossRefPubMed

44.

Blashill AJ, Safren SA, Wilhelm S, Jampel J, Taylor SW, O’Cleirigh C, et al. Cognitive behavioral therapy for body image and self-care (CBT-BISC) in sexual minority men living with HIV: A randomized controlled trial. Heal Psychol Off J Div Heal Psychol Am Psychol Assoc. 2017;36:937–46.

45.

Madhombiro M, Dube B, Dube M, Zunza M, Chibanda D, Rusakaniko S, et al. Intervention for alcohol use disorders at an HIV care clinic in Harare: a pilot and feasibility study. Addict Sci Clin Pract. 2019;14:16.PubMedPubMedCentral

46.

Kahler CW, Pantalone DW, Mastroleo NR, Liu T, Bove G, Ramratnam B, et al. Motivational interviewing with personalized feedback to reduce alcohol use in HIV-infected men who have sex with men: a randomized controlled trial. J Consult Clin Psychol. 2018;86:645–56.PubMedPubMedCentral

47.

Madhombiro M, Dube-Marimbe B, Dube M, Chibanda D, Zunza M, Rusakaniko S, et al. A cluster randomised controlled trial protocol of an adapted intervention for alcohol use disorders in people living with HIV and AIDS: impact on alcohol use, general functional ability, quality of life and adherence to HAART. BMC Psychiatry. 2017;17:44.PubMedPubMedCentral

48.

Rollnick S, Allison J. The Essential Handbook of Treatment and prevention of alcohol problems. Essent Handb Treat Prev Alcohol Probl. 2004.

49.

Boucher LM, Liddy C, Mihan A, Kendall C. Peer-led self-management interventions and adherence to antiretroviral therapy among people living with HIV: a systematic review. AIDS Behav. 2020;24:998–1022. https://doi.org/10.1007/s10461-019-02690-7.CrossRefPubMed

50.

Areri HA, Marshall A, Harvey G. Interventions to improve self-management of adults living with HIV on antiretroviral therapy: a systematic review. PLoS One. Public Library of Science. 2020;15:e0232709. https://doi.org/10.1371/journal.pone.0232709.CrossRefPubMedPubMedCentral

51.

Mark D, Hrapcak S, Ameyan W, Lovich R, Ronan A, Schmitz K, et al. Peer support for adolescents and young people living with HIV in sub-Saharan Africa: emerging insights and a methodological agenda. Curr HIV/AIDS Rep. 2019;16:467–74. https://doi.org/10.1007/s11904-019-00470-5.CrossRefPubMedPubMedCentral

52.

Ruria EC, Masaba R, Kose J, Woelk G, Mwangi E, Matu L, et al. Optimizing linkage to care and initiation and retention on treatment of adolescents with newly diagnosed HIV infection. AIDS [Internet]. Lippincott Williams & Wilkins; 2017;31 Suppl 3:S253–60. Available from: https://pubmed.ncbi.nlm.nih.gov/28665883

53.

Locher C, Messerli M, Gaab J, Gerger H. Long-term effects of psychological interventions to improve adherence to antiretroviral treatment in HIV-infected persons: a systematic review and meta-analysis. AIDS Patient Care STDs Mary Ann Liebert, Inc. 2019;33:131–44. https://doi.org/10.1089/apc.2018.0164.CrossRefPubMed

54.

Pellowski JA, Kalichman SC. Recent advances (2011-2012) in technology-delivered interventions for people living with HIV. Curr HIV/AIDS Rep. 2012;9:326–34. https://doi.org/10.1007/s11904-012-0133-9.CrossRefPubMedPubMedCentral

55.

Swendeman D, Rotheram-Borus MJ. Innovation in sexually transmitted disease and HIV prevention: Internet and mobile phone delivery vehicles for global diffusion. Curr. Opin. Psychiatry. Swendeman, Dallas: Center for Community Health, University of California, Los Angeles, 10920 Wilshire Boulevard, Suite 350, Los Angeles, CA, US, 90024, dswendeman@mednet.ucla.edu: Lippincott Williams & Wilkins; 2010. p. 139–44.

56.

Claborn KR, Fernandez A, Wray T, Ramsey S. Computer-based HIV adherence promotion interventions: a systematic review: Translation Behavioral Medicine. Transl Behav Med. 2015;5:294–306.PubMedPubMedCentral

57.

Fisher JD, Amico KR, Fisher WA, Cornman DH, Shuper PA, Trayling C, et al. Computer-based intervention in HIV clinical care setting improves antiretroviral adherence: the LifeWindows Project. AIDS Behav United States. 2011;15:1635–46.

58.

Hersch RK, Cook RF, Billings DW, Kaplan S, Murray D, Safren S, et al. Test of a web-based program to improve adherence to HIV medications. AIDS Behav. 2013;17:2963–76.PubMed

59.

Ownby RL, Waldrop-Valverde D, Caballero J, Jacobs RJ. Baseline medication adherence and response to an electronically delivered health literacy intervention targeting adherence. Neurobehav HIV Med. 2012;4:113–21.PubMedPubMedCentral

60.

Remien RH, Hirky AE, Johnson MO, Weinhardt LS, Whittier D, Le GM. Adherence to medication treatment: a qualitative study of facilitators and barriers among a diverse sample of HIV+ men and women in four U.S. cities. AIDS Behav. 2003;7:61–72. https://doi.org/10.1023/A:1022513507669.CrossRefPubMed

61.

Encyclopedia of Behavioral Medicine. Encycl. Behav. Med. Springer Science+Business Media; 2013

62.

Demonceau J, Ruppar T, Kristanto P, Hughes DA, Fargher E, Kardas P, et al. Identification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta-analysis. Drugs. 2013;73:545–62.PubMedPubMedCentral

63.

Vrijens B, Urquhart J, White D. Electronically monitored dosing histories can be used to develop a medication-taking habit and manage patient adherence. Expert Rev Clin Pharmacol England. 2014;7:633–44.

64.

Mbuagbaw L, Hajizadeh A, Wang A, Mertz D, Lawson DO, Smieja M, et al. Overview of systematic reviews on strategies to improve treatment initiation, adherence to antiretroviral therapy and retention in care for people living with HIV: part 1. BMJ Open. 2020;10:e034793.PubMedPubMedCentral

65.

Craker L, Tarantino N, Whiteley L, Brown L. Measuring antiretroviral adherence among young people living with HIV: observations from a real-time monitoring device versus self-report. AIDS Behav [Internet]. 2019;23:2138–45 Available from: https://pubmed.ncbi.nlm.nih.gov/30888573.

66.

Van der Elst EM, Mbogua J, Operario D, Mutua G, Kuo C, Mugo P, et al. High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya. AIDS Behav. 2013;17:2162–72.PubMedPubMedCentral

67.

van Heuckelum M, van den Ende CHM, Houterman AEJ, Heemskerk CPM, van Dulmen S, van den Bemt BJF. The effect of electronic monitoring feedback on medication adherence and clinical outcomes: a systematic review. PLoS One Public Library of Science. 2017;12:e0185453. https://doi.org/10.1371/journal.pone.0185453.CrossRefPubMedPubMedCentral

68.

Mayer JE, Fontelo P. Meta-analysis on the effect of text message reminders for HIV-related compliance. AIDS Care - Psychol Socio-Medical Asp AIDS/HIV. 2017;29:409–17.

69.

Taylor D, Lunny C, Lolić P, Warje O, Geldman J, Wong T, et al. Effectiveness of text messaging interventions on prevention, detection, treatment, and knowledge outcomes for sexually transmitted infections (STIs)/HIV: a systematic review and meta-analysis. Syst Rev. 2019;8:12.PubMedPubMedCentral

70.

Abiodun O, Ladi-Akinyemi B, Olu-Abiodun O, Sotunsa J, Bamidele F, Adepoju A, et al. A single-blind, parallel design RCT to assess the effectiveness of SMS Reminders in Improving ART adherence among adolescents living with HIV (STARTA Trial). United States: J Adolesc Heal Off Publ Soc Adolesc Med; 2020.

71.

Cao B, Gupta S, Wang J, Hightow-Weidman LB, Muessig KE, Tang W, et al. Social media interventions to promote HIV testing, linkage, adherence, and retention: systematic review and meta-analysis. J Med Internet Res. 2017;19:e394.PubMedPubMedCentral

72.

Horvath KJ, Oakes JM, Rosser BRS, Danilenko G, Vezina H, Amico KR, et al. Feasibility, acceptability and preliminary efficacy of an online peer-to-peer social support ART adherence intervention. AIDS Behav. 2013;17:2031–44.PubMedPubMedCentral

73.

Dulli L, Ridgeway K, Packer C, Murray KR, Mumuni T, Plourde KF, et al. A social media-based support group for youth living with HIV in Nigeria (SMART Connections): randomized controlled trial. J Med Internet Res. 2020;22:e18343.PubMedPubMedCentral

74.

Horvath KJ, Amico KR, Erickson D, Ecklund AM, Martinka A, DeWitt J, et al. Thrive With Me: protocol for a randomized controlled trial to test a peer support intervention to improve antiretroviral therapy adherence among men who have sex with men. JMIR Res Protoc. 2018;7:e10182.PubMedPubMedCentral

75.

LeGrand S, Muessig KE, McNulty T, Soni K, Knudtson K, Lemann A, et al. Epic allies: development of a gaming app to improve antiretroviral therapy adherence among young HIV-positive men who have sex with men. JMIR Serious Games. 2016;4:e6.PubMedPubMedCentral

76.

Kato PM. Video games in health care: closing the gap. Rev Gen Psychol SAGE Publications Inc. 2010;14:113–21. https://doi.org/10.1037/a0019441.CrossRef

77.

Hightow-Weidman LB, Muessig KE, Bauermeister JA, LeGrand S, Fiellin LE. The future of digital games for HIV prevention and care. Curr. Opin. HIV AIDS. 2017.

78.

Ritterfeld U, Cody M, Vorderer P. Serious games: mechanisms and effects. Serious Games Mech. Eff. 2009.

79.

LeGrand S, Muessig KE, Platt A, Soni K, Egger JR, Nwoko N, et al. Epic allies, a gamified mobile phone app to improve engagement in care, antiretroviral uptake, and adherence among young men who have sex with men and young transgender women who have sex with men: protocol for a randomized controlled trial. JMIR Res Protoc. 2018;7:e94.PubMedPubMedCentral

80.

Baranowski T, Baranowski J, Cullen KW, Marsh T, Islam N, Zakeri I, et al. Squire’s Quest! Dietary outcome evaluation of a multimedia game. Am J Prev Med Netherlands. 2003;24:52–61.

81.

Brown SJ, Lieberman DA, Germeny BA, Fan YC, Wilson DM, Pasta DJ. Educational video game for juvenile diabetes: results of a controlled trial. Med Inform (Lond). England. 1997;22:77–89.

82.

Kato PM, Cole SW, Bradlyn AS, Pollock BH. A video game improves behavioral outcomes in adolescents and young adults with cancer: a randomized trial. Pediatrics United States. 2008;122:e305–17.

83.

Fogg B. A behavior model for persuasive design. ACM Int Conf Proceeding Ser. 2009.

84.

Medich M, Swendeman DT, Comulada WS, Kao UH, Myers JJ, Brooks RA, et al. Promising approaches for engaging youth and young adults living with hiv in hiv primary care using social media and mobile technology interventions: protocol for the spns social media initiative. JMIR Res Protoc. 2019.

85.

Dillingham R, Ingersoll K, Flickinger TE, Waldman AL, Grabowski M, Laurence C, et al. PositiveLinks: a mobile health intervention for retention in HIV care and clinical outcomes with 12-month follow-up. AIDS Patient Care STDS. Dillingham, Rebecca: UVA School of Medicine, P.O. Box 801379, Charlottesville, VA, US, 22908, rd8v@virginia.edu: Mary Ann Liebert, Inc.; 2018. p. 241–50.

86.

UNC Behavior and Technology Lab. The UNC/EMORY Center For Innovative Technology [Internet]. Available from: https://batlab.web.unc.edu/itech/

87.

Chibanda D. Depression and HIV: integrated care towards 90-90-90. Int Health. 2017.

88.

Rubin LH, Maki PM. HIV, depression, and cognitive impairment in the era of effective antiretroviral therapy. Curr HIV/AIDS Rep. 2019;16:82–95.PubMedPubMedCentral

89.

Enane LA, Vreeman RC, Foster C. Retention and adherence: global challenges for the long-term care of adolescents and young adults living with HIV. Curr Opin HIV AIDS United States. 2018;13:212–9.

90.

Centers for Disease Control and Prevention (CDC). HIV and Youth. 2020.

91.

Beer L, Mattson CL, Shouse RL, Prejean J. Receipt of clinical and prevention services, clinical outcomes, and sexual risk behaviors among HIV-infected young adults in care in the United States. AIDS Care Taylor & Francis. 2016;28:1166–70. https://doi.org/10.1080/09540121.2016.1160028.CrossRefPubMedPubMedCentral

92.

Ritchwood TD, Malo V, Jones C, Metzger IW, Atujuna M, Marcus R, et al. Healthcare retention and clinical outcomes among adolescents living with HIV after transition from pediatric to adult care: a systematic review. BMC Public Health. 2020;20:1195. https://doi.org/10.1186/s12889-020-09312-1.CrossRefPubMedPubMedCentral

93.

Whiteley L, Brown LK, Mena L, Craker L, Arnold T. Enhancing health among youth living with HIV using an iPhone game. AIDS Care - Psychol Socio-Medical Asp AIDS/HIV. 2018;30:21–33.

94.

Ghidei L, Simone MJ, Salow MJ, Zimmerman KM, Paquin AM, Skarf LM, et al. Aging, antiretrovirals, and adherence: a meta analysis of adherence among older HIV-infected individuals. Drugs Aging. 2013;30:809–19.PubMed

95.

Johnson CJ, Heckman TG, Hansen NB, Kochman A, Sikkema KJ. Adherence to antiretroviral medication in older adults living with HIV/AIDS: a comparison of alternative models. AIDS Care. 2009;21:541–51.PubMedPubMedCentral

96.

McCoy K, Waldrop-Valverde D, Balderson BH, Mahoney C, Catz S. Correlates of antiretroviral therapy adherence among HIV-infected older adults. J Int Assoc Provid AIDS Care. 2016;15:248–55.PubMed

97.

Centers for Disease Control and Prevention (CDC). HIV and Women. 2020.

98.

Joint United Nations Programme on HIV/AIDS (UNAIDS). We’ve got the power — women, adolescent girls and the HIV response [Internet]. 2020. Available from: https://www.unaids.org/sites/default/files/media_asset/2020_women-adolescent-girls-and-hiv_en.pdf

99.

Brown JL, Littlewood RA, Vanable PA. Social-cognitive correlates of antiretroviral therapy adherence among HIV-infected individuals receiving infectious disease care in a medium-sized northeastern US city. AIDS Care [Internet]. 2013/01/11. 2013;25:1149–58. Available from: https://pubmed.ncbi.nlm.nih.gov/23311323

100.

Lambert CC, Mugavero MJ, Najjar YS, Enah C, Guthrie BJ. The state of adherence to HIV care in Black women. J Assoc Nurses AIDS Care. 2018;29:487–503.PubMedPubMedCentral

101.

Pellowski JA, Price DM, Harrison AD, Tuthill EL, Myer L, Operario D, et al. A systematic review and meta-analysis of antiretroviral therapy (ART) adherence interventions for women living with HIV. AIDS Behav [Internet]. 2019;23:1998–2013. Available from. 2019. https://doi.org/10.1007/s10461-018-2341-9.

102.

Bailey H, Zash R, Rasi V, Thorne C. HIV treatment in pregnancy. Lancet HIV. Elsevier. 2018;5:e457–67. https://doi.org/10.1016/S2352-3018(18)30059-6.CrossRef

103.

Adams JW, Brady KA, Michael YL, Yehia BR, Momplaisir FM. Postpartum engagement in HIV care: an important predictor of long-term retention in care and viral suppression. Clin Infect Dis. 2015;61:1880–7. https://doi.org/10.1093/cid/civ678.CrossRefPubMed

104.

Momplaisir FM, Storm DS, Nkwihoreze H, Jayeola O, Jemmott JB. Improving postpartum retention in care for women living with HIV in the United States. AIDS [Internet]. 2018;32. Available from: https://journals.lww.com/aidsonline/Fulltext/2018/01140/Improving_postpartum_retention_in_care_for_women.1.aspx

105.

Omonaiye O, Nicholson P, Kusljic S, Manias E. A meta-analysis of effectiveness of interventions to improve adherence in pregnant women receiving antiretroviral therapy in sub-Saharan Africa. Int J Infect Dis Elsevier. 2018;74:71–82. https://doi.org/10.1016/j.ijid.2018.07.004.CrossRefPubMed

106.

Centers for Disease Control and Prevention (CDC). HIV and Transgender People [Internet]. 2019. Available from: https://www.cdc.gov/hiv/pdf/group/gender/transgender/cdc-hiv-transgender-factsheet.pdf

107.

Dowshen N, Matone M, Luan X, Lee S, Belzer M, Fernandez MI, et al. Behavioral and health outcomes for HIV+ young transgender women (YTW) linked to and engaged in medical care. LGBT Heal. 2016;3:162–7.

108.

Baguso GN, Gay CL, Lee KA. Medication adherence among transgender women living with HIV. AIDS Care Taylor & Francis. 2016;28:976–81. https://doi.org/10.1080/09540121.2016.1146401.CrossRefPubMedPubMedCentral

109.

U.S. Department of Health & Human Services. HIV Basics: U.S. Statistics [Internet]. 2020. Available from: https://www.hiv.gov/hiv-basics/overview/data-and-trends/statistics

110.

Centers for Disease Control and Prevention (CDC). HIV basics: basic statistics. Div. HIV/AIDS Prev. Natl. Cent. HIV/AIDS, Viral Hepatitis, STD, TB Prev. 2021.

111.

Safren SA, Perry NS, Blashill AJ, O’Cleirigh C, Mayer KH. The cost and intensity of behavioral interventions to promote HIV treatment for prevention among HIV-positive men who have sex with men. Arch Sex Behav. 2015;44:1833–41. https://doi.org/10.1007/s10508-014-0455-3.CrossRefPubMedPubMedCentral

112.

Quinn KG, Voisin DR. ART adherence among men who have sex with men living with HIV: key challenges and opportunities. Curr HIV/AIDS Rep. 2020;17:290–300.PubMedPubMedCentral

113.

Mutchler MG, Bogart LM, Klein DJ, Wagner GJ, Klinger IA, Tyagi K, et al. Age matters: differences in correlates of self-reported HIV antiretroviral treatment adherence between older and younger Black men who have sex with men living with HIV. AIDS Care - Psychol Socio-Medical Asp AIDS/HIV. 2019;31:965–72.

114.

Crepaz N, Dong X, Wang X, Hernandez AL, Hall HI. Racial and ethnic disparities in sustained viral suppression and transmission risk potential among persons receiving HIV care - United States, 2014. MMWR Morb Mortal Wkly Rep. 2018;67:113–8.PubMedPubMedCentral

115.

Pence BW, Gaynes BN, Williams Q, Modi R, Adams J, Quinlivan EB, et al. Assessing the effect of Measurement-Based Care depression treatment on HIV medication adherence and health outcomes: rationale and design of the SLAM DUNC Study. Contemp Clin Trials. 2012;33:828–38.PubMedPubMedCentral

116.

Pence BW, Gaynes BN, Adams JL, Thielman NM, Heine AD, Mugavero MJ, et al. The effect of antidepressant treatment on HIV and depression outcomes: Results from a randomized trial. AIDS. 2015;29:1975–86.PubMed

117.

Turan B, Rice WS, Crockett KB, Johnson M, Neilands TB, Ross SN, et al. Longitudinal association between internalized HIV stigma and antiretroviral therapy adherence for women living with HIV: the mediating role of depression. AIDS. 2019;33:571–6.PubMed

118.

Sin NL, DiMatteo MR. Depression treatment enhances adherence to antiretroviral therapy: a meta-analysis. Ann Behav Med. 2014;47:259–69.PubMed

119.

Turner BJ, Laine C, Cosler L, Hauck WW. Relationship of gender, depression, and health care delivery with antiretroviral adherence in HIV-infected drug users. J Gen Intern Med. 2003;18:248–57.PubMedPubMedCentral

120.

Akincigil A, Wilson IB, Walkup JT, Siegel MJ, Huang C, Crystal S. Antidepressant treatment and adherence to antiretroviral medications among privately insured persons with HIV/AIDS. AIDS Behav. 2011;

121.

Horberg MA, Silverberg MJ, Hurley LB, Towner WJ, Klein DB, Bersoff-Matcha S, et al. Effects of depression and selective serotonin reuptake inhibitor use on adherence to highly active antiretroviral therapy and on clinical outcomes in HIV-infected patients. J Acquir Immune Defic Syndr. 2008;

122.

Kong MC, Nahata MC, Lacombe VA, Seiber EE, Balkrishnan R. Association between race, depression, and antiretroviral therapy adherence in a low-income population with HIV infection. J Gen Intern Med. 2012;

123.

Passchier RV, Abas MA, Ebuenyi ID, Pariante CM. Effectiveness of depression interventions for people living with HIV in sub-Saharan Africa: a systematic review & meta-analysis of psychological & immunological outcomes. Brain Behav Immun. 2018;73:261–73.PubMed

124.

Brown LK, Kennard BD, Emslie GJ, Mayes TL, Whiteley LB, Bethel J, et al. Effective treatment of depressive disorders in medical clinics for adolescents and young adults living with HIV: a controlled trial. J Acquir Immune Defic Syndr. 2016;71:38–46.PubMedPubMedCentral

125.

Brown L, Chernoff M, Kennard B, Emslie G, Shapiro D, Lypen K, AW SBuisson, Whiteley L, Traite S, Krotje C, Harriff L and ET for the I 2020 team. Site-randomized controlled trial of a combined cognitive behavioral therapy and a medication management algorithm for treatment of depression among youth living with HIV in the United States. 23rd Int AIDS Conf (AIDS 2020).

126.

Graves JC, Elyanu P, Schellack CJ, Asire B, Prust ML, Prescott MR, et al. Impact of a family clinic day intervention on paediatric and adolescent appointment adherence and retention in antiretroviral therapy: a cluster randomized controlled trial in Uganda. PLoS One. 2018;13:e0192068.PubMedPubMedCentral

127.

Claborn K, Becker S, Operario D, Safren S, Rich JD, Ramsey S. Adherence intervention for HIV-infected persons who use drugs: adaptation, open trial, and pilot randomized hybrid type 1 trial protocol. Addict Sci Clin Pract. 2018;13:12.PubMedPubMedCentral

128.

Altice FL, Maru DSR, Bruce RD, Springer SA, Friedland GH. Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: A prospective, randomized, controlled trial. Clin Infect Dis. 2007;45:770–8.PubMed

129.

Fanucchi L, Springer SA, Korthuis PT. Medications for treatment of opioid use disorder among persons living with HIV. Curr HIV/AIDS Rep. 2019;16:1–6.PubMedPubMedCentral

130.

Lucas GM, Mullen BA, Weidle PJ, Hader S, McCaul ME, Moore RD. Directly administered antiretroviral therapy in methadone clinics is associated with improved HIV treatment outcomes, compared with outcomes among concurrent comparison groups. Clin Infect Dis an Off Publ Infect Dis Soc Am. United States. 2006;42:1628–35.

131.

González-Álvarez S, Madoz-Gúrpide A, Parro-Torres C, Hernández-Huerta D, Mangado EO. Relationship between alcohol consumption, whether linked to other substance use or not, and antiretroviral treatment adherence in HIV+ patients. Adicciones. 2019.

132.

Perlman DC, Jordan AE. The Syndemic of Opioid Misuse, Overdose, HCV, and HIV: structural-level causes and interventions. Curr HIV/AIDS Rep. 2018;15:96–112.PubMedPubMedCentral

133.

van Luenen S, Garnefski N, Spinhoven P, Spaan P, Dusseldorp E, Kraaij V. The benefits of psychosocial interventions for mental health in people living with HIV: a systematic review and meta-analysis. AIDS Behav. 2018.

134.

Centers for Disease Control and Prevention (CDC). Complete listing of medication adherence evidence-based behavioral interventions. 2020.

135.

Baumann AA, Cabassa LJ. Reframing implementation science to address inequities in healthcare delivery. BMC Health Serv Res. 2020;

136.

Eisman AB, Kilbourne AM, Dopp AR, Saldana L, Eisenberg D. Economic evaluation in implementation science: making the business case for implementation strategies. Psychiatry Res. 2020;283:112433.PubMed

137.

Roberts SLE, Healey A, Sevdalis N. Use of health economic evaluation in the implementation and improvement science fields - a systematic literature review. Implement. Sci. 2019

Titel: A Review of Interventions to Enhance HIV Medication Adherence
verfasst von: Laura B. Whiteley
Elizabeth M. Olsen
Kayla K. Haubrick
Enyonam Odoom
Nicholas Tarantino
Larry K. Brown
Publikationsdatum: 21.06.2021
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 5/2021
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-021-00568-9

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