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Erschienen in: Current Rheumatology Reports 12/2014

01.12.2014 | Pediatric Rheumatology (S Ozen, Section Editor)

Enthesitis-Related Arthritis: Time to Re-define?

verfasst von: Angela R. Bryan, C. Egla Rabinovich

Erschienen in: Current Rheumatology Reports | Ausgabe 12/2014

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Abstract

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. Enthesitis-related arthritis (ERA) is one of the seven JIA subtypes classified by the International League of Associations for Rheumatology (ILAR). Due to inclusion and exclusion criteria, a pitfall of the ERA category is that it does not include all subsets of juvenile spondyloarthropathy, with many children ending up in the undifferentiated category. The ERA nomenclature also does not have a method for distinguishing between axial and peripheral disease, two phenotypes which vary in presentation and treatment requirements. This distinction is very important given the overall poor prognosis seen in ERA patients, specifically in those with axial involvement. Since axial involvement is more common and presents earlier than previously thought in ERA, the pediatric rheumatology community should develop more accurate and sensitive classification criteria based on disease course to assist in improving timely diagnosis and appropriate management.
Literatur
1.
Zurück zum Zitat Rosenberg AM, Petty RE. A syndrome of seronegative enthesopathy and arthropathy in children. Arthritis Rheum. 1982;25(9):1041–7.PubMedCrossRef Rosenberg AM, Petty RE. A syndrome of seronegative enthesopathy and arthropathy in children. Arthritis Rheum. 1982;25(9):1041–7.PubMedCrossRef
2.
Zurück zum Zitat Petty RE et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31(2):390–2.PubMed Petty RE et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31(2):390–2.PubMed
3.
Zurück zum Zitat Flato B et al. Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study. Arthritis Rheum. 2006;54(11):3573–82.PubMedCrossRef Flato B et al. Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study. Arthritis Rheum. 2006;54(11):3573–82.PubMedCrossRef
4.
Zurück zum Zitat Hofer M. Spondylarthropathies in children—are they different from those in adults? Best Pract Res Clin Rheumatol. 2006;20(2):315–28.PubMedCrossRef Hofer M. Spondylarthropathies in children—are they different from those in adults? Best Pract Res Clin Rheumatol. 2006;20(2):315–28.PubMedCrossRef
5.
6.•
Zurück zum Zitat Ramanathan A, Srinivasalu H, Colbert RA. Update on juvenile spondyloarthritis. Rheum Dis Clin N Am. 2013;39(4):767–88. This is a review of juvenile spondyloarthropathies, including clinical features, genetics and therapeutic options.CrossRef Ramanathan A, Srinivasalu H, Colbert RA. Update on juvenile spondyloarthritis. Rheum Dis Clin N Am. 2013;39(4):767–88. This is a review of juvenile spondyloarthropathies, including clinical features, genetics and therapeutic options.CrossRef
7.
Zurück zum Zitat Kasapcopur O et al. Evaluation of classification criteria for juvenile-onset spondyloarthropathies. Rheumatol Int. 2005;25(6):414–8.PubMedCrossRef Kasapcopur O et al. Evaluation of classification criteria for juvenile-onset spondyloarthropathies. Rheumatol Int. 2005;25(6):414–8.PubMedCrossRef
8.
Zurück zum Zitat Stoll ML et al. Patients with juvenile psoriatic arthritis comprise two distinct populations. Arthritis Rheum. 2006;54(11):3564–72.PubMedCrossRef Stoll ML et al. Patients with juvenile psoriatic arthritis comprise two distinct populations. Arthritis Rheum. 2006;54(11):3564–72.PubMedCrossRef
9.••
Zurück zum Zitat Butbul Aviel Y et al. Juvenile psoriatic arthritis (JPsA): juvenile arthritis with psoriasis? Pediatr Rheumatol Online J. 2013;11(1):11. A cohort of children with JPsA were examined for unifying clinical features and long term outcomes.PubMedCentralPubMedCrossRef Butbul Aviel Y et al. Juvenile psoriatic arthritis (JPsA): juvenile arthritis with psoriasis? Pediatr Rheumatol Online J. 2013;11(1):11. A cohort of children with JPsA were examined for unifying clinical features and long term outcomes.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat O’Shea FD et al. Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis. Ann Rheum Dis. 2009;68(9):1407–12.PubMedCrossRef O’Shea FD et al. Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis. Ann Rheum Dis. 2009;68(9):1407–12.PubMedCrossRef
11.••
Zurück zum Zitat Chen HA et al. Clinical, functional, and radiographic differences among juvenile-onset, adult-onset, and late-onset ankylosing spondylitis. J Rheumatol. 2012;39(5):1013–8. The differences between pediatric and adult onset ankylosing spondylitis examined in a large cohort of Taiwanese patients.PubMedCrossRef Chen HA et al. Clinical, functional, and radiographic differences among juvenile-onset, adult-onset, and late-onset ankylosing spondylitis. J Rheumatol. 2012;39(5):1013–8. The differences between pediatric and adult onset ankylosing spondylitis examined in a large cohort of Taiwanese patients.PubMedCrossRef
12.
Zurück zum Zitat van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27(4):361–8.PubMedCrossRef van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27(4):361–8.PubMedCrossRef
13.
Zurück zum Zitat Rudwaleit M et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68(6):777–83.PubMedCrossRef Rudwaleit M et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis. 2009;68(6):777–83.PubMedCrossRef
15.•
Zurück zum Zitat Fisher C et al. Enthesitis-related arthritis; a new era of understanding. Ann Paediatr Rheum. 2012;1(1):8–16. A review of differences between axial and peripheral ERA.CrossRef Fisher C et al. Enthesitis-related arthritis; a new era of understanding. Ann Paediatr Rheum. 2012;1(1):8–16. A review of differences between axial and peripheral ERA.CrossRef
16.
Zurück zum Zitat Chen J, Liu C. Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials. J Rheumatol. 2006;33(4):722–31.PubMed Chen J, Liu C. Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials. J Rheumatol. 2006;33(4):722–31.PubMed
17.
Zurück zum Zitat Haibel H et al. No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Ann Rheum Dis. 2007;66(3):419–21.PubMedCentralPubMedCrossRef Haibel H et al. No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Ann Rheum Dis. 2007;66(3):419–21.PubMedCentralPubMedCrossRef
19.
Zurück zum Zitat Selvaag AM et al. Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study. J Rheumatol. 2005;32(6):1122–30.PubMed Selvaag AM et al. Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study. J Rheumatol. 2005;32(6):1122–30.PubMed
20.
Zurück zum Zitat van der Heijde D et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther. 2009;11(4):R127.PubMedCentralPubMedCrossRef van der Heijde D et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther. 2009;11(4):R127.PubMedCentralPubMedCrossRef
21.
Zurück zum Zitat Althoff CE et al. Magnetic resonance imaging of active sacroiliitis: do we really need gadolinium? Eur J Radiol. 2009;71(2):232–6.PubMedCrossRef Althoff CE et al. Magnetic resonance imaging of active sacroiliitis: do we really need gadolinium? Eur J Radiol. 2009;71(2):232–6.PubMedCrossRef
22.•
Zurück zum Zitat Weiss PF et al. Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care Res (Hoboken). 2011;63(9):1307–12. Examination of characteristics of an inception cohort of patients with ERA.CrossRef Weiss PF et al. Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care Res (Hoboken). 2011;63(9):1307–12. Examination of characteristics of an inception cohort of patients with ERA.CrossRef
23.•
Zurück zum Zitat Pagnini I et al. Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. J Rheumatol. 2010;37(11). Prospective study of ERA, examining incidence of sacroiliitis and early predictors for development of sacroiliitis. Pagnini I et al. Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. J Rheumatol. 2010;37(11). Prospective study of ERA, examining incidence of sacroiliitis and early predictors for development of sacroiliitis.
24.•
Zurück zum Zitat Stoll ML et al. Spondyloarthritis in a pediatric population: risk factors for sacroiliitis. J Rheumatol. 2010;37(11):2402–8. Authors retrospectively examined risk factors for sacroiliitis, finding hip arthritis an important predictor.PubMedCentralPubMedCrossRef Stoll ML et al. Spondyloarthritis in a pediatric population: risk factors for sacroiliitis. J Rheumatol. 2010;37(11):2402–8. Authors retrospectively examined risk factors for sacroiliitis, finding hip arthritis an important predictor.PubMedCentralPubMedCrossRef
25.
Zurück zum Zitat Bollow M et al. Use of dynamic magnetic resonance imaging to detect sacroiliitis in HLA-B27 positive and negative children with juvenile arthritides. J Rheumatol. 1998;25(3):556–64.PubMed Bollow M et al. Use of dynamic magnetic resonance imaging to detect sacroiliitis in HLA-B27 positive and negative children with juvenile arthritides. J Rheumatol. 1998;25(3):556–64.PubMed
26.••
Zurück zum Zitat Vendhan K et al. Inflammatory changes of the lumbar spine in children and adolescents with enthesitis-related arthritis: magnetic resonance imaging findings. Arthritis Care Res (Hoboken). 2014;66(1):40–6. MRI abnormalities in the spine are examined and compared to a control population.CrossRef Vendhan K et al. Inflammatory changes of the lumbar spine in children and adolescents with enthesitis-related arthritis: magnetic resonance imaging findings. Arthritis Care Res (Hoboken). 2014;66(1):40–6. MRI abnormalities in the spine are examined and compared to a control population.CrossRef
27.
Zurück zum Zitat Minden K et al. Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46(9):2392–401.PubMedCrossRef Minden K et al. Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum. 2002;46(9):2392–401.PubMedCrossRef
28.•
Zurück zum Zitat Berntson L et al. HLA-B27 predicts a more chronic disease course in an 8-year followup cohort of patients with juvenile idiopathic arthritis. J Rheumatol. 2013;40(5):725–31. Large incident cohort of children with JIA prospectively examined and clinical characteristics examined and compared in HLA-B27 positive and negative patients.PubMedCrossRef Berntson L et al. HLA-B27 predicts a more chronic disease course in an 8-year followup cohort of patients with juvenile idiopathic arthritis. J Rheumatol. 2013;40(5):725–31. Large incident cohort of children with JIA prospectively examined and clinical characteristics examined and compared in HLA-B27 positive and negative patients.PubMedCrossRef
29.•
Zurück zum Zitat Donnithorne KJ, Cron RQ, Beukelman T. Attainment of inactive disease status following initiation of TNF-alpha inhibitor therapy for juvenile idiopathic arthritis: enthesitis-related arthritis predicts persistent active disease. J Rheumatol. 2011;38(12):2675–81. Retrospective, single site study of JIA patients with examination of attainment of inactive disease, and risk factors for persistent active disease after initiation of anti-TNF therapy.PubMedCentralPubMedCrossRef Donnithorne KJ, Cron RQ, Beukelman T. Attainment of inactive disease status following initiation of TNF-alpha inhibitor therapy for juvenile idiopathic arthritis: enthesitis-related arthritis predicts persistent active disease. J Rheumatol. 2011;38(12):2675–81. Retrospective, single site study of JIA patients with examination of attainment of inactive disease, and risk factors for persistent active disease after initiation of anti-TNF therapy.PubMedCentralPubMedCrossRef
30.••
Zurück zum Zitat Boiu S et al. Functional status in severe juvenile idiopathic arthritis in the biologic treatment era: an assessment in a French paediatric rheumatology referral centre. Rheumatology (Oxford). 2012;51(7):1285. Disability, pain and functional status examined in a cohort of patients with JIA.CrossRef Boiu S et al. Functional status in severe juvenile idiopathic arthritis in the biologic treatment era: an assessment in a French paediatric rheumatology referral centre. Rheumatology (Oxford). 2012;51(7):1285. Disability, pain and functional status examined in a cohort of patients with JIA.CrossRef
31.••
Zurück zum Zitat Weiss PF et al. Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. J Rheumatol. 2012;39(12):2341–51. Pain and health status examined in a large cross sectional study of JIA patients.PubMedCentralPubMedCrossRef Weiss PF et al. Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. J Rheumatol. 2012;39(12):2341–51. Pain and health status examined in a large cross sectional study of JIA patients.PubMedCentralPubMedCrossRef
32.
Zurück zum Zitat Tse SM et al. Radiologic improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. J Rheumatol. 2006;33(6):1186–8.PubMed Tse SM et al. Radiologic improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. J Rheumatol. 2006;33(6):1186–8.PubMed
Metadaten
Titel
Enthesitis-Related Arthritis: Time to Re-define?
verfasst von
Angela R. Bryan
C. Egla Rabinovich
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 12/2014
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-014-0466-z

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