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Drugs
Erschienen in: Drugs 5/2017

01.04.2017 | Current Opinion

Therapeutic Options in Refractory Diabetic Macular Oedema

verfasst von: Sanket U. Shah, Raj K. Maturi

Erschienen in: Drugs | Ausgabe 5/2017

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Abstract

Diabetic macular oedema (DMO) results from alterations of several biochemical pathways in diabetic eyes. Centre-involving DMO is an important cause of visual loss in diabetes. Anti-vascular endothelial growth factor agents are now the mainstay of centre-involving DMO treatment. Oedema that does not achieve optimal response to these agents occurs in a sizeable proportion of eyes and is called refractory or persistent DMO. Management of refractory DMO is challenging. In this paper, the pathophysiology of DMO, and the definitions used in various studies are summarised. Therapeutic options for refractory DMO management including corticosteroids, laser, combination therapies, and surgery are explored. Novel agents on the horizon for DMO control that are being investigated at present are discussed as well. A literature review was performed and a summary of the research studies for each of the agents is provided in order to guide the reader regarding the existing evidence for their application in DMO. Importance of early recognition of disease and prompt treatment to achieve best visual outcome is discussed. Utility of optical coherence tomography to guide disease diagnosis and monitoring is highlighted. An algorithmic approach for DMO management is described. Finally, the impact that personalized medicine and genetics might have on DMO management is assessed.
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Metadaten
Titel
Therapeutic Options in Refractory Diabetic Macular Oedema
verfasst von
Sanket U. Shah
Raj K. Maturi
Publikationsdatum
01.04.2017
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 5/2017
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-017-0704-6

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