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Erschienen in:
01.02.2012 | Original Research Paper
Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis
Erschienen in: Inflammation Research | Ausgabe 2/2012
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Objective
To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE).
Methods
A meta-analysis was conducted on the associations between the 4b/a, G894T, and C786T polymorphisms of eNOS and SLE and lupus nephritis (LN) (when available) using (1) the allele contrast, (2) the recessive, (3) the dominant, and (4) the additive models.
Results
A total of eight studies, which included 1,297 cases and 1,214 controls, were included in the meta-analysis. Meta-analysis showed no association between SLE and the 4b/a polymorphism in any study subjects. Stratification by presence of LN indicated a significant association between the a allele and the aa + ab genotype of the 4b/a polymorphism and LN in SLE patients [odds ratio (OR) = 2.125, 95% confidence interval (CI) = 1.289–3.054, p = 0.003; OR = 2.655, 95% CI = 1.509–4.671, p = 0.001]. No association was found between SLE and the G894T polymorphism using the allelic, recessive, or dominant, or additive models. Meta-analysis of the T786C polymorphism showed a tendency to an association between the TT genotype and SLE (OR = 1.220, 95% CI = 1.000–1.489, p = 0.050), and meta-analysis of the TT versus CC genotype of the C786T polymorphism in group in Hardy–Weinberg equilibrium revealed a significant association between the TT genotype and SLE (OR = 1.643, 95% CI = 1.021–2.644, p = 0.041).
Conclusions
This meta-analysis of published studies shows that the 4b/a polymorphism may be associated with the development of LN, and the C786T polymorphism may be associated with SLE susceptibility.