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Erschienen in: Herz 6/2015

01.09.2015 | Original article

Serum NT-proBNP on admission can predict ST-segment resolution in patients with acute myocardial infarction after primary percutaneous coronary intervention

verfasst von: Dr. Bin Peng, Dr. Hao Xia, Aihua Ni, Gang Wu, Xuejun Jiang

Erschienen in: Herz | Ausgabe 6/2015

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Abstract

Objective

The aim of this study was to investigate the value of initial serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in ST-segment elevation myocardial infarction (STEMI) patients for predicting ST-segment resolution (STR) after primary percutaneous coronary intervention (pPCI).

Patients and methods

Consecutive STEMI patients (n = 218) who underwent pPCI were assigned to an STR group (≥ 50 % resolution) or a non-STR group (< 50 % resolution). All patients were followed up for 12 months, and major adverse cardiac events were recorded. Data related to the pPCI procedure, biochemical parameters, and cardiac markers were compared between the two groups. Predictive factors of non-STR were also identified.

Results

STR at 180 min after pPCI occurred in 202 patients (92.7 %). Compared to the STR group, patients in the non-STR group had a significantly lower left ventricular ejection fraction, a larger left ventricular end-diastolic dimension, and significantly higher serum concentrations of glycosylated hemoglobin and NT-proBNP. Multivariate logistic regression analysis indicated that a high serum NT-proBNP level in STEMI patients on hospital admission was the only independent predictive factor of non-STR after pPCI. An NT-proBNP concentration of ≥ 2,563.6 pg/ml had a sensitivity of 81.2 % and a specificity of 65.8 %.

Conclusions

Serum NT-proBNP concentrations in STEMI patients on hospital admission were useful in predicting non-STR after pPCI.
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Metadaten
Titel
Serum NT-proBNP on admission can predict ST-segment resolution in patients with acute myocardial infarction after primary percutaneous coronary intervention
verfasst von
Dr. Bin Peng
Dr. Hao Xia
Aihua Ni
Gang Wu
Xuejun Jiang
Publikationsdatum
01.09.2015
Verlag
Urban & Vogel
Erschienen in
Herz / Ausgabe 6/2015
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI
https://doi.org/10.1007/s00059-015-4309-0

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