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Erschienen in:

17.08.2016 | Original Article

Less increase of CT-based calcium scores of the coronary arteries

Effect three years after breast-conserving radiotherapy using breath-hold

verfasst von: M. E. Mast, PhD, M. W. Heijenbrok, MD, M. L. van Kempen-Harteveld, MD PhD, A. L. Petoukhova, PhD, A. N. Scholten, MD PhD, R. Wolterbeek, J. H. M. Schreur, MD PhD, H. Struikmans, MD PhD

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 10/2016

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Abstract

Purpose

The aim of this prospective longitudinal study was to compare coronary artery calcium (CAC) scores determined before the start of whole breast irradiation with those determined 3 years afterwards.

Patients and methods

Changes in CAC scores were analysed in 99 breast cancer patients. Three groups were compared: patients receiving left- and right-sided radiotherapy, and those receiving left-sided radiotherapy with breath-hold. We analysed overall CAC scores and left anterior descending (LAD) and right coronary artery (RCA) CAC scores. Between the three groups, changes of the value of the LAD minus the RCA CAC scores of each individual patient were also compared.

Results

Three years after breath-hold-based whole breast irradiation, a less pronounced increase of CAC scores was noted. Furthermore, LAD minus RCA scores in patients treated for left-sided breast cancer without breath-hold were higher when compared to LAD minus RCA scores of patients with right-sided breast cancers and those with left-sided breast cancer treated with breath-hold.

Conclusion

Breath-hold in breast-conserving radiotherapy leads to a less pronounced increase of CT-based CAC scores. Therefore, breath-hold probably prevents the development of radiation-induced coronary artery disease. However, the sample size of this study is limited and the follow-up period relatively short.

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Titel: Less increase of CT-based calcium scores of the coronary arteries
Effect three years after breast-conserving radiotherapy using breath-hold
verfasst von: M. E. Mast, PhD
M. W. Heijenbrok, MD
M. L. van Kempen-Harteveld, MD PhD
A. L. Petoukhova, PhD
A. N. Scholten, MD PhD
R. Wolterbeek
J. H. M. Schreur, MD PhD
H. Struikmans, MD PhD
Publikationsdatum: 17.08.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 10/2016
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-016-1026-4

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