Erschienen in:
01.12.2003 | Comment
–To: Poa NR, Cooper GJS, Edgar PF: Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori. Diabetologia 46: 574–578
verfasst von:
A. Novials, A. Kistauri, A. Chico, R. Gomis
Erschienen in:
Diabetologia
|
Ausgabe 12/2003
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Excerpt
To the Editor: Poa et al. [
1] screened for amylin gene mutations in New Zealand Maori and identified two different mutations in the promoter region of the amylin gene (−215 T/G and −132-G/A) and a missense mutation in exon 3 (Q10R), with a prevalence of 5.4%, 0.76% and 0.76%, respectively, in Type 2 diabetic Maori patients. The authors suggest that amylin is likely to be a susceptibility gene for Type 2 diabetes in this population, which has a high prevalence of diabetes. …