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Diabetologia

Erschienen in:

01.01.2005 | Article

Leisure time physical activity and the risk of type 2 diabetes in men and women from the general population

The MONICA/KORA Augsburg Cohort Study

verfasst von: C. Meisinger, H. Löwel, B. Thorand, A. Döring

Erschienen in: Diabetologia | Ausgabe 1/2005

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Abstract

Aims/hypothesis

The aim of this study was to examine sex-specific associations between leisure time physical activity and incident type 2 diabetes in a representative population sample in Germany.

Methods

The study was based on 4,069 men and 4,034 women (aged 25 to 74 years) who participated in one of the three MONICA Augsburg surveys between 1984 and 1995. Subjects were free of diabetes at baseline. Incident cases of type 2 diabetes were assessed in 1998 using a follow-up questionnaire. Sex-specific hazard ratios (HRs) were estimated from Cox proportional hazard models.

Results

A total of 145 cases of incident type 2 diabetes among men and 82 among women were registered during the mean follow-up period of 7.4 years. In both sexes, a high leisure time physical activity level was associated with a reduced risk of incident type 2 diabetes. After adjustment for confounding factors, the HR in highly active men (more than 2 h physical activity per week in summer and winter) was 0.83 (95% CI: 0.50–1.36). In contrast, highly active women had the lowest risk of type 2 diabetes even after multivariable adjustment (HR 0.24; 95% CI: 0.06–0.98). In subgroup analyses, after multivariable adjustment, the protective effect of moderate to high physical activity was significant in women with a BMI below 30 kg/m² (HR 0.24; 95% CI: 0.09–0.65) but not in women with a BMI of 30 kg/m² or higher (HR 0.97; 95% CI: 0.44–2.11).

Conclusions/interpretation

Leisure time physical activity is effective in preventing type 2 diabetes, especially in nonobese women, in the general population.

King H, Aubert R, Herman W (1998) Global burden of diabetes, 1995–2025: prevalence, numerical estimates and projections. Diabetes Care 21:1414–1431PubMed

Amos A, McCarty D, Zimmet P (1997) The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med 14:S1–S85

Rathmann W, Haastert B, Icks A et al (2003) High prevalence of undiagnosed diabetes mellitus in southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia 46:182–189PubMed

Tuomilehto J, Korhonen HJ, Kartovaara L et al (1991) Prevalence of diabetes mellitus and impaired glucose tolerance in the middle-aged population of three areas in Finland. Int J Epidemiol 20:1010–1017PubMed

Mooy JM, Grootenhuis PA, de Vries H et al (1995) Prevalence and determinants of glucose intolerance in a Dutch Caucasian population. The Hoorn Study. Diabetes Care 18:1270–1273PubMed

Stolk RP, Pols HAP, Lamberts SWJ et al (1997) Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. The Rotterdam Study. Am J Epidemiol 145:24–32PubMed

Ivy JL, Zderic TW, Fogt DL (1999) Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev 27:1–35

Tuomilehto J, Lindström J, Eriksson J et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350CrossRefPubMed

Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403CrossRefPubMed

10.

Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147–152PubMed

11.

Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH (1992) A prospective study of exercise and incidence of diabetes among US male physicians. JAMA 268:63–67CrossRefPubMed

12.

Manson JE, Rimm EB, Stampfer MJ et al (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774–778CrossRefPubMed

13.

Hu G, Qiao Q, Silventoinen K et al (2003) Occupational, commuting, and leisure-time physical activity in relation to risk for type 2 diabetes in middle-aged Finnish men and women. Diabetologia 46:322–329PubMed

14.

Burchfiel CM, Sharp DS, Curb JD et al (1995) Physical activity and incidence of diabetes: the Honolulu Heart Program. Am J Epidemiol 141:360–368PubMed

15.

Hu FB, Sigal RJ, Rich-Edwards JW et al (1999) Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA 282:1433–1439CrossRefPubMed

16.

Keil U, Liese AD, Hense HW et al (1998) Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany. Results from the MONICA Augsburg Cohort Study 1984–1992. Eur Heart J 19:1197–1207PubMed

17.

WHO MONICA Project Principal Investigators (prepared by H. Tunstall-Pedoe) (1988) The World Health Organization MONICA Project (Monitoring of Trends and Determinants in Cardiovascular Disease): a major international collaboration. J Clin Epidemiol 34:105–114

18.

Hense HW, Filipiak B, Döring A, Stieber J, Liese A, Keil U (1998) Ten-year trends of cardiovascular risk factors in the MONICA Augsburg Region in Southern Germany. Results from the 1984/85, 1989/90 and 1994/1995 surveys. CVD Prev 1:318–327

19.

Meisinger C, Thorand B, Schneider A, Stieber J, Döring A, Löwel H (2002) Sex differences in risk factors for incident type 2 diabetes mellitus. The MONICA Augsburg Cohort Study. Arch Intern Med 162:82–89PubMed

20.

Cox DR (1972) Regression models and life tables. J R Stat Soc 34:187–220

21.

Perry IJ, Wannamethee SG, Walker MK, Thomson AG, Whincup PH, Shaper AG (1995) Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. BMJ 310:560–564PubMed

22.

Lynch J, Helmrich SP, Lakka TA et al (1996) Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch Intern Med 156:1307–1314CrossRefPubMed

23.

Folsom AR, Kushi LH, Hong CP (2000) Physical activity and incident diabetes mellitus in postmenopausal women. Am J Public Health 90:134–138PubMed

24.

Hu FB, Li TY, Colditz GA, Willett WC, Manson JE (2003) Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289:1785–1791PubMed

25.

Wannamethee SG, Shaper AG, Alberti KGMM (2000) Physical activity, metabolic factors, and the incidence of coronary heart disease and type 2 diabetes. Arch Intern Med 160:2108–2116CrossRefPubMed

26.

Haapanen N, Miilunpalo S, Vuori I, Oja P, Pasanen M (1997) Association of leisure time physical activity with the risk of coronary heart disease, hypertension and diabetes in middle-aged men and women. Int J Epidemiol 26:739–747CrossRefPubMed

27.

Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, Blair SN (1999) The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 130:89–96PubMed

28.

King DS, Dalsky GP, Staten MA, Clutter WE, Van Houten DR, Holloszy JO (1987) Insulin action and secretion in endurance-trained and untrained humans. J Appl Physiol 63:2247–2252PubMed

29.

Folsom AR, Jacobs DR Jr, Wagenknecht LE et al (1996) Increase in fasting insulin and glucose over seven years with increasing weight and inactivity of young adults: the CARDIA Study. Am J Epidemiol 144:235–246PubMed

30.

Mayer-Davies EJ, D’Agostino R, Karter AJ et al (1998) Intensity and amount of physical activity in relation to insulin sensitivity. The insulin resistance atherosclerosis study. JAMA 279:669–674PubMed

31.

Pan XR, Li GW, Hu YH et al (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20:537–544PubMed

32.

Weller I, Corey P (1998) The impact of excluding non-leisure energy expenditure on the relation between physical activity and mortality in women. Epidemiology 9:632–635CrossRefPubMed

Titel: Leisure time physical activity and the risk of type 2 diabetes in men and women from the general population
The MONICA/KORA Augsburg Cohort Study
verfasst von: C. Meisinger
H. Löwel
B. Thorand
A. Döring
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 1/2005
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-004-1604-3

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Abstract

Aims/hypothesis

Methods

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