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Erschienen in:
01.06.2006 | Erratum
Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects
Erschienen in: Diabetologia | Ausgabe 6/2006
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Unfortunately the values given for insulin sensitivity and disposition index (DI) in Tables 2 and 3 of this article were incorrect. The corrected tables are reproduced here. There was also a mistake in the legend for Figure 3 which should have read: ‘Data points and bars are mean ± SE for insulin sensitivity and for beta cell glucose sensitivity’, instead of ‘Data points and bars are mean ± SE for insulin sensitivity and median ± SE for beta cell glucose sensitivity’.
Table 2
Baseline metabolic parameters according to progression to hyperglycaemia
|
|
Progressors
|
Non-progressors
|
p
|
|---|---|---|---|
|
Fasting ISR (pmol min−1 m−2)
|
76 (36)
|
61 (28)
|
<0.05
|
|
Total IS (nmol m−2)
|
45 (22)
|
37 (20)
|
0.09
|
|
Beta cell glucose sensitivity (pmol min−1 m−2 mmol/l−1)
|
75 (48)
|
110 (98)
|
0.02
|
|
Rate sensitivity (nmol m−2 mmol/l−1)
|
0.6 (0.7)
|
0.7 (0.8)
|
NS
|
|
Potentiation (fold)
|
1.4 (0.7)
|
1.7 (1.0)
|
NS
|
|
Insulin sensitivity (ml min−1 m−2)
|
359±55
|
405±63
|
0.001
|
|
ΔI30/ΔG30 (pmol/mmol)
|
95 (91)
|
122 (104)
|
NS
|
|
DI (ml min−1 m−2 pmol mmol−1)
|
34 (33)
|
46 (39)
|
<0.02
|
Table 3
Changes in metabolic data between baseline and 5 years according to progression to hyperglycaemia
|
|
Progressors
|
Non-progressors
|
p
|
|---|---|---|---|
|
BMI
|
1.8±2.6
|
0.8±2.3
|
0.001
|
|
Fasting ISR
|
18 (38)
|
3 (37)
|
0.01
|
|
Total IS
|
3 (24)
|
1 (22)
|
NS
|
|
Beta-cell glucose sensitivity
|
−36 (36)
|
−13 (105)
|
<0.0001
|
|
Rate sensitivity
|
−0.1 (0.7)
|
0.01 (0.9)
|
NS
|
|
Potentiation
|
0.1 (0.9)
|
−0.1 (1.2)
|
NS
|
|
Insulin sensitivity
|
−36±57
|
5±48
|
<0.0001
|
|
ΔI30/ΔG30
|
−31 (60)
|
−21 (74)
|
0.03
|
|
DI
|
−13 (18)
|
−9 (27)
|
0.0001
|