Anzeige
Erschienen in:
01.12.2011 | Article
Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS)
Erschienen in: Diabetologia | Ausgabe 12/2011
Einloggen, um Zugang zu erhaltenAbstract
Aims/hypothesis
Glycated albumin is a measure of the mean plasma glucose concentration over approximately 2–3 weeks. We determined reference values for glycated albumin, and assessed its utility for the diagnosis of type 2 diabetes mellitus in the general population.
Methods
We studied 1,575 men and women (mean age, 49.9 years; range, 26–78 years) who participated in a periodic health examination in a suburban Japanese town. HbA1c and fasting plasma concentrations of glucose (FPG) and glycated albumin were measured. Participants with FPG ≥ 7.0 mmol/l or HbA1c
≥ 6.5% (48 mmol/mol) were diagnosed as having diabetes. In our laboratory, the glycated albumin assay had intra-assay and inter-assay CVs of 1.1% and 1.6%, respectively.
Results
Glycated albumin levels were significantly correlated with HbA1c levels (r = 0.766, p < 0.001) and FPG (r = 0.706, p < 0.001). The presence of diabetes was significantly higher in participants with glycated albumin levels between 15.0% and 15.9% (five of 276, 1.81%) than in those with glycated albumin <14% (three of 672, 0.45%) (p = 0.037), and was markedly increased in those with a glycated albumin level >16% (58 of 207, 28.0%). Receiver operating characteristic curve analysis indicated that a glycated albumin level of ≥15.5% was optimal for predicting diabetes, with a sensitivity of 83.3% and a specificity of 83.3%.
Conclusions/interpretation
There is merit to further investigating the potential for glycated albumin to be used as an alternative measure of dysglycaemia for future research and clinical practice.