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Knee Surgery, Sports Traumatology, Arthroscopy
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 2/2017

23.08.2015 | Experimental Study

Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential

verfasst von: Kivanc Atesok, Freddie H. Fu, Ichiro Sekiya, Alexandra Stolzing, Mitsuo Ochi, Scott A. Rodeo

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 2/2017

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Abstract

Purpose

The purpose of this study was to summarize the current evidence on the use of stem cells in the elderly population with degenerative orthopaedic pathologies and to highlight the pathophysiologic mechanisms behind today’s therapeutic challenges in stem cell-based regeneration of destructed tissues in the elderly patients with osteoarthritis (OA), degenerative disc disease (DDD), and tendinopathies.

Methods

Clinical and basic science studies that report the use of stem cells in the elderly patients with OA, DDD, and tendinopathies were identified using a PubMed search. The studies published in English have been assessed, and the best and most recent evidence was included in the current study.

Results

Evidence suggests that, although short-term results regarding the effects of stem cell therapy in degenerative orthopaedic pathologies can be promising, stem cell therapies do not appear to reverse age-related tissue degeneration. Causes of suboptimal outcomes can be attributed to the decrease in the therapeutic potential of aged stem cell populations and the regenerative capacity of these cells, which might be negatively influenced in an aged microenvironment within the degenerated tissues of elderly patients with OA, DDD, and tendinopathies.

Conclusions

Clinical protocols guiding the use of stem cells in the elderly patient population are still under development, and high-level randomized controlled trials with long-term outcomes are lacking. Understanding the consequences of age-related changes in stem cell function and responsiveness of the in vivo microenvironment to stem cells is critical when designing cell-based therapies for elderly patients with degenerative orthopaedic pathologies.
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Metadaten
Titel
Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential
verfasst von
Kivanc Atesok
Freddie H. Fu
Ichiro Sekiya
Alexandra Stolzing
Mitsuo Ochi
Scott A. Rodeo
Publikationsdatum
23.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 2/2017
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-015-3763-9

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