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Osteoporosis International

Erschienen in:

01.12.2006 | Review

Osteoporosis prevention and therapy: preserving and building strength through bone quality

verfasst von: M. Kleerekoper

Erschienen in: Osteoporosis International | Ausgabe 12/2006

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Abstract

While bone mineral density measurements play a central role in osteoporosis management, the degree to which increases in this parameter contribute to bone fragility, fracture risk, and the therapeutic efficacy of osteoporosis agents is controversial. Indeed, bone strength is also significantly dependent upon bone turnover and bone quality, including microarchitecture, mineralization, and geometry. Given the critical role of these factors, it is essential to understand how they are affected by therapeutic agents. Even though a number of technological advances, such as microcomputed tomography, magnetic resonance imaging, and computerized analysis of radiographic patterns, help to provide critical information toward a more comprehensive assessment of bone turnover and bone quality, clinical trials addressing these factors are scarce. This article provides a review of studies relating to how osteoporosis therapies impact parameters of bone strength and quality.

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Titel: Osteoporosis prevention and therapy: preserving and building strength through bone quality
verfasst von: M. Kleerekoper
Publikationsdatum: 01.12.2006
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 12/2006
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0187-x

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