nach oben

Experimental Brain Research

Erschienen in:

01.01.2008 | Research Article

Influence of galvanic vestibular stimulation on egocentric and object-based mental transformations

verfasst von: Bigna Lenggenhager, Christophe Lopez, Olaf Blanke

Erschienen in: Experimental Brain Research | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

The vestibular system analyses angular and linear accelerations of the head that are important information for perceiving the location of one’s own body in space. Vestibular stimulation and in particular galvanic vestibular stimulation (GVS) that allow a systematic modification of vestibular signals has so far mainly been used to investigate vestibular influence on sensori-motor integration in eye movements and postural control. Comparatively, only a few behavioural and imaging studies have investigated how cognition of space and body may depend on vestibular processing. This study was designed to differentiate the influence of left versus right anodal GVS compared to sham stimulation on object-based versus egocentric mental transformations. While GVS was applied, subjects made left-right judgments about pictures of a plant or a human body presented at different orientations in the roll plane. All subjects reported illusory sensations of body self-motion and/or visual field motion during GVS. Response times in the mental transformation task were increased during right but not left anodal GVS for the more difficult stimuli and the larger angles of rotation. Post-hoc analyses suggested that the interfering effect of right anodal GVS was only present in subjects who reported having imagined turning themselves to solve the mental transformation task (egocentric transformation) as compared to those subjects having imagined turning the picture in space (object-based mental transformation). We suggest that this effect relies on shared functional and cortical mechanisms in the posterior parietal cortex associated with both right anodal GVS and mental imagery.

Nur mit Berechtigung zugänglich

The upright (0°) and the upside-down conditions (180°) were not included in this first ANOVA since they cannot be assigned to either a clockwise or counterclockwise Stimulus Orientation and subjects reported having used other strategies than mental rotation for the 180°angle (see below).

Bächtold D, Baumann T, Sandor PS, Kritos M, Regard M, Brugger P (2001) Spatial- and verbal-memory improvement by cold-water caloric stimulation in healthy subjects. Exp Brain Res 136:128–132PubMedCrossRef

Bent LR, McFadyen BJ, Merkley VF, Kennedy PM, Inglis JT (2000) Magnitude effects of galvanic vestibular stimulation on the trajectory of human gait. Neurosci Lett 279:157–160PubMedCrossRef

Blanke O, Landis T, Spinelli L, Seeck M (2004) Out-of-body experience and autoscopy of neurological origin. Brain 127:243–258PubMedCrossRef

Blanke O, Mohr C, Michel CM, Pascual-Leone A, Brugger P, Seeck M, Landis T, Thut G (2005) Linking out-of-body experience and self processing to mental own-body imagery at the temporoparietal junction. J Neurosci 25:550–557PubMedCrossRef

Blanke O, Ortigue S, Landis T, Seeck M (2002) Stimulating illusory own-body perceptions. Nature 419:269–270PubMedCrossRef

Bottini G, Paulesu E, Gandola M, Loffredo S, Scarpa P, Sterzi R, Santilli I, Defanti CA, Scialfa G, Fazio F, Vallar G (2005) Left caloric vestibular stimulation ameliorates right hemianesthesia. Neurology 65:1278–1283PubMedCrossRef

Brainard DH (1997) The psychophysics toolbox. Spatial Vision 10:443–446

Brandt T, Schautzer F, Hamilton DA, Bruning R, Markowitsch HJ, Kalla R, Darlington C, Smith P, Strupp M (2005) Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain 128:2732–2741PubMedCrossRef

Cappa S, Sterzi R, Vallar G, Bisiach E (1987) Remission of hemineglect and anosognosia during vestibular stimulation. Neuropsychologia 25:775–782PubMedCrossRef

Cooper L (1975) Mental rotation of random two-dimensional shapes. Cogn Psychol 7:20–43CrossRef

Creem SH, Downs TH, Wraga M, Harrington GS, Proffitt DR, Downs JH 3rd (2001) An fMRI study of imagined self-rotation. Cogn Affect Behav Neurosci 1:239–249PubMedCrossRef

Devinsky O, Feldmann E, Burrowes K, Bromfield E (1989) Autoscopic phenomena with seizures. Arch Neurol 46:1080–1088PubMed

Fink GR, Marshall JC, Weiss PH, Stephan T, Grefkes C, Shah NJ, Zilles K, Dieterich M (2003) Performing allocentric visuospatial judgments with induced distortion of the egocentric reference frame: an fMRI study with clinical implications. Neuroimage 20:1505–1517PubMedCrossRef

Fitzpatrick RC, Day BL (2004) Probing the human vestibular system with galvanic stimulation. J Appl Physiol 96:2301–2316PubMedCrossRef

Fitzpatrick RC, Marsden J, Lord SR, Day BL (2002) Galvanic vestibular stimulation evokes sensations of body rotation. Neuroreport 13:2379–83PubMedCrossRef

George MS, Wassermann EM, Post RM (1996) Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century. J Neuropsychiatry Clin Neurosci 8:373–382PubMed

Glasauer S, Amorim MA, Viaud-Delmon I, Berthoz A (2002) Differential effects of labyrinthine dysfunction on distance and direction during blindfolded walking of a triangular path. Exp Brain Res 145:489–497PubMedCrossRef

Grabherr L, Bach S, Indermaur K, Metzler S, Mast F (2007) Mental transformations of bodies and body-parts in microgravity. J Vest Res (in press)

Hartley T, Maguire EA, Spiers HJ, Burgess N (2003) The well-worn route and the path less traveled: distinct neural bases of route following and wayfinding in humans. Neuron 37:877–888PubMedCrossRef

Jordan K, Wustenberg T, Heinze HJ, Peters M, Jancke L (2002) Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsychologia 40:2397–2408PubMedCrossRef

Kahane P, Hoffmann D, Minotti L, Berthoz A (2003) Reappraisal of the human vestibular cortex by cortical electrical stimulation study. Ann Neurol 54:615–624PubMedCrossRef

Karnath HO, Dieterich M (2006) Spatial neglect-a vestibular disorder? Brain 129:293–305PubMedCrossRef

Kosslyn SM, DiGirolamo GJ, Thompson WL, Alpert NM (1998) Mental rotation of objects versus hands: neural mechanisms revealed by positron emission tomography. Psychophysiology 35:151–161PubMedCrossRef

Lacour M, Bonnet M, Roll JP (1974) [Spinal effects of electric vestibular stimulation in man. Demonstrated evidence of vestibular prevalence and role in motion laterality]. Acta Otolaryngol 78:399–409PubMed

Lane NE, Kennedy, RS (1988) A new method for quantifying simulator sickness: development and application of the simulator sickness questionnaire (SSQ). Technical Report No. EOTR 88-7, Essex Corporation, Orlando

Lenggenhager B, Smith S, Blanke O (2006) Functional and neural mechanisms of embodiment: Importance of the vestibular system and the temporal parietal junction. Rev Neurosci 17:643–657PubMed

Lobel E, Kleine JF, Bihan DL, Leroy-Willig A, Berthoz A (1998) Functional MRI of galvanic vestibular stimulation. J Neurophysiol 80:2699–2709PubMed

Lopez C, Blanke O (2007) Neuropsychology and neurophysiology of self-consciousness. Multisensory and vestibular mechanisms. In: Holderegger A, Sitter-Liver B, Hess CW (eds) Hirnforschung und Menschenbild. Beiträge zur interdisziplinären Verständigung. Schwabe, Basel

Lopez C, Lacour M, Ballester M, Dumitrescu M, Anton J-L, Nazarian B, Roth M, Borel L (2005) Brain activations during subjective visual vertical judgment: a functional magnetic resonance imaging study. Gait and Posture 21(Suppl 1):13

MacDougall HG, Brizuela AE, Burgess AM, Curthoys IS (2002) Between-subject variability and within-subject reliability of the human eye-movement response to bilateral galvanic (DC) vestibular stimulation. Exp Brain Res 144:69–78PubMedCrossRef

MacDougall HG, Moore ST, Curthoys IS, Black FO (2006) Modeling postural instability with Galvanic vestibular stimulation. Exp Brain Res 172:208–220PubMedCrossRef

Mars F, Vercher JL, Popov K (2005) Dissociation between subjective vertical and subjective body orientation elicited by galvanic vestibular stimulation. Brain Res Bull 65:77–86PubMedCrossRef

Mast FW, Meissner F (2004) Mental transformations of perspective during whole-body roll-rotation. J Vestib Res 14:113

Mast FW, Merfeld DM, Kosslyn SM (2006) Visual mental imagery during caloric vestibular stimulation. Neuropsychologia 44:101–109PubMedCrossRef

Ohlmann T, Marendaz C (1991) Vicarious processes involved in spatial perception. In: Wapner S (ed) Bio-psycho-social factors in cognitive style. Lawrence Erlbaum, Hillsdale, pp 106–129

Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113PubMedCrossRef

Parsons LM (1987) Imagined spatial transformation of one’s body. J Exp Psychol Gen 116:172–191PubMedCrossRef

Pascual-Leone A, Rubio B, Pallardo F, Catala MD (1996) Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 348:233–237PubMedCrossRef

Pelli DG (1997) The VideoToolbox sotware for visual psychophysics: transforming numbers into movies. Spat Vis 10:437–442PubMed

Penfield W, Erickson T (1941) Epilepsy and Cerebral Localization, Charles C. Thomas, Springfield

Peruch P, Borel L, Gaunet F, Thinus-Blanc G, Magnan J, Lacour M (1999) Spatial performance of unilateral vestibular defective patients in nonvisual versus visual navigation. J Vestib Res 9:37–47PubMed

Peruch P, Borel L, Magnan J, Lacour M (2005) Direction and distance deficits in path integration after unilateral vestibular loss depend on task complexity. Brain Res Cogn Brain Res 25:862–872PubMedCrossRef

Quarck G, Etard O, Normand H, Pottier M, Denise P (1998) Low intensity galvanic vestibulo-ocular reflex in normal subjects. Neurophysiol Clin 28:413–422PubMedCrossRef

Rode G, Charles N, Perenin MT, Vighetto A, Trillet M, Aimard G (1992) Partial remission of hemiplegia and somatoparaphrenia through vestibular stimulation in a case of unilateral neglect. Cortex 28:203–208PubMed

Rodionov V, Zislin J, Elidan J (2004) Imagination of body rotation can induce eye movements. Acta Otolaryngol 124:684–689PubMedCrossRef

Saj A, Honore J, Rousseaux M (2006) Perception of the vertical in patients with right hemispheric lesion: Effect of galvanic vestibular stimulation. Neuropsychologia 44:1509–1512PubMedCrossRef

Shepard RN, Metzler J (1971) Mental rotation of three-dimensional objects. Science 171:701–703PubMedCrossRef

Smith PF, Zheng Y, Horii A, Darlington CL (2005) Does vestibular damage cause cognitive dysfunction in humans? J Vestib Res 15:1–9PubMed

Stephan T, Deutschlander A, Nolte A, Schneider E, Wiesmann M, Brandt T, Dieterich M (2005) Functional MRI of galvanic vestibular stimulation with alternating currents at different frequencies. Neuroimage 26:721–732PubMedCrossRef

Vallar G (1998) Spatial Hemineglect in Human. Trends Cogn Sci 2:87–97CrossRef

Vallar G, Lobel E, Galati G, Berthoz A, Pizzamiglio L, Le Bihan D (1999) A fronto-parietal system for computing the egocentric spatial frame of reference in humans. Exp Brain Res 124:281–286PubMedCrossRef

Vingerhoets G, Santens P, Van Laere K, Lahorte P, Dierckx RA, De Reuck J (2001) Regional brain activity during different paradigms of mental rotation in healthy volunteers: a positron emission tomography study. Neuroimage 13:381–391PubMedCrossRef

Vogeley K, Fink GR (2003) Neural correlates of the first-person-perspective. Trends Cogn Sci 7:38–42PubMedCrossRef

Wraga M, Shephard JM, Church JA, Inati S, Kosslyn SM (2005) Imagined rotations of self versus objects: an fMRI study. Neuropsychologia 43:1351–1361PubMedCrossRef

Zacks JM, Michelon P (2005) Transformations of visuospatial images. Behav Cogn Neurosci Rev 4:96–118PubMedCrossRef

Zacks JM, Tversky B (2005) Multiple systems for spatial imagery: transformations of objects and bodies. Spatial Cognit Comput 5:271–306CrossRef

Zacks J, Rypma B, Gabrieli JD, Tversky B, Glover GH (1999) Imagined transformations of bodies: an fMRI investigation. Neuropsychologia 37:1029–1040PubMedCrossRef

Zink R, Bucher SF, Weiss A, Brandt T, Dieterich M (1998) Effects of galvanic vestibular stimulation on otolithic and semicircular canal eye movements and perceived vertical. Electroencephalogr Clin Neurophysiol 107:200–205PubMedCrossRef

Titel: Influence of galvanic vestibular stimulation on egocentric and object-based mental transformations
verfasst von: Bigna Lenggenhager
Christophe Lopez
Olaf Blanke
Publikationsdatum: 01.01.2008
Verlag: Springer-Verlag
Erschienen in: Experimental Brain Research / Ausgabe 2/2008
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-007-1095-9

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Stability of rhythmic visuo-motor tracking does not depend on relative velocity

Visual guidance of landing behaviour when stepping down to a new level

Target size modifies anticipatory postural adjustments and subsequent elementary arm pointing

Interval timing and Parkinson’s disease: heterogeneity in temporal performance

Walking speed, cadence and step length are selected to optimize the stability of head and pelvis accelerations