Urinalysis of 24-h urine | Subjects (n = 37: 19 male, 18 female) | |||
---|---|---|---|---|
l-Hydroxyproline | ||||
0 mg/day (n = 10: 5 M, 5 F) | 500 mg/day (n = 9: 5 M, 4 F) | 1000 mg/day (n = 10, 5 M, 5 M) | 2000 mg/day (n = 8: 4 M, 4 F) | |
Na (g/day) | ||||
Pre-intake | 3.1 ± 1 | 2.8 ± 1.2 | 3.2 ± 0.9 | 3 ± 0.8 |
4 weeks after first intake | 3 ± 1 | 3.5 ± 1.2 | 3.6 ± 1.1 | 4 ± 0.6 |
8 weeks after first intake | 2.3 ± 1 | 1.9 ± 0.8 | 3 ± 1 | 2.7 ± 0.7 |
12 weeks after first intake | 3.3 ± 1 | 3.6 ± 1.2 | 3.3 ± 0.9 | 3.9 ± 1.3 |
4 weeks after final intake | 3.5 ± 1.6 | 3.1 ± 0.7 | 3.4 ± 0.8 | 3.3 ± 1.2 |
K (g/day) | ||||
Pre-intake | 0.67 ± 0.27 | 0.66 ± 0.28 | 0.82 ± 0.25 | 0.72 ± 0.24 |
4 weeks after first intake | 0.67 ± 0.2 | 0.6 ± 0.27 | 0.7 ± 0.22 | 0.81 ± 0.25 |
8 weeks after first intake | 0.56 ± 0.19 | 0.55 ± 0.3 | 0.56 ± 0.22 | 0.61 ± 0.18 |
12 weeks after first intake | 0.68 ± 0.29 | 0.68 ± 0.24 | 0.61 ± 0.24 | 0.71 ± 0.28 |
4 weeks after final intake | 0.7 ± 0.3 | 0.59 ± 0.29 | 0.67 ± 0.19 | 0.66 ± 0.3 |
Ca (g/day) | ||||
Pre-intake | 0.16 ± 0.07 | 0.13 ± 0.06 | 0.12 ± 0.04 | 0.11 ± 0.04 |
4 weeks after first intake | 0.19 ± 0.08 | 0.16 ± 0.04 | 0.17 ± 0.05 | 0.17 ± 0.05 |
8 weeks after first intake | 0.12 ± 0.04 | 0.1 ± 0.03 | 0.12 ± 0.05 | 0.12 ± 0.04 |
12 weeks after first intake | 0.14 ± 0.08 | 0.15 ± 0.08 | 0.13 ± 0.05 | 0.14 ± 0.07 |
4 weeks after final intake | 0.13 ± 0.07 | 0.12 ± 0.09 | 0.12 ± 0.05 | 0.13 ± 0.04 |
Mg (g/day) | ||||
Pre-intake | 0.04 ± 0.02 | 0.05 ± 0.03 | 0.06 ± 0.02 | 0.04 ± 0.01 |
4 weeks after first intake | 0.05 ± 0.02 | 0.05 ± 0.02 | 0.07 ± 0.02 | 0.06 ± 0.02 |
8 weeks after first intake | 0.04 ± 0.01 | 0.05 ± 0.02 | 0.05 ± 0.01 | 0.05 ± 0.02 |
12 weeks after first intake | 0.05 ± 0.02 | 0.06 ± 0.02 | 0.06 ± 0.01 | 0.05 ± 0.02 |
4 weeks after final intake | 0.04 ± 0.01 | 0.05 ± 0.02 | 0.06 ± 0.01* | 0.05 ± 0.02 |
Inorganic phosphorus (g/day) | ||||
Pre-intake | 0.47 ± 0.21 | 0.41 ± 0.18 | 0.52 ± 0.12 | 0.47 ± 0.1 |
4 weeks after first intake | 0.48 ± 0.18 | 0.45 ± 0.12 | 0.54 ± 0.08 | 0.55 ± 0.16 |
8 weeks after first intake | 0.57 ± 0.2 | 0.49 ± 0.1 | 0.6 ± 0.22 | 0.59 ± 0.13 |
12 weeks after first intake | 0.55 ± 0.27 | 0.51 ± 0.2 | 0.54 ± 0.13 | 0.51 ± 0.17 |
4 weeks after final intake | 0.48 ± 0.14 | 0.41 ± 0.18 | 0.51 ± 0.16 | 0.49 ± 0.16 |
Uric acid (g/day) | ||||
Pre-intake | 0.19 ± 0.06 | 0.15 ± 0.06 | 0.17 ± 0.08 | 0.13 ± 0.04 |
4 weeks after first intake | 0.19 ± 0.05 | 0.17 ± 0.07 | 0.17 ± 0.06 | 0.15 ± 0.04 |
8 weeks after first intake | 0.12 ± 0.03 | 0.09 ± 0.03 | 0.12 ± 0.06 | 0.11 ± 0.04 |
12 weeks after first intake | 0.15 ± 0.05 | 0.13 ± 0.03 | 0.14 ± 0.04 | 0.14 ± 0.06 |
4 weeks after final intake | 0.16 ± 0.03 | 0.11 ± 0.03 | 0.14 ± 0.05 | 0.12 ± 0.05 |
Urea nitrogen (g/day) | ||||
Pre-intake | 6.14 ± 2.78 | 5.9 ± 2.45 | 6.7 ± 2.02 | 5.67 ± 1.6 |
4 weeks after first intake | 6.74 ± 2.44 | 6.29 ± 1.63 | 7.17 ± 1.37 | 7.42 ± 2.08 |
8 weeks after first intake | 7.04 ± 2.65 | 6.53 ± 1.68 | 7.19 ± 1.9 | 7.71 ± 1.23 |
12 weeks after first intake | 6.84 ± 2.92 | 6.78 ± 1.34 | 6.96 ± 1.58 | 6.87 ± 2.06 |
4 weeks after final intake | 6.08 ± 1.43 | 6.15 ± 1.71 | 6.73 ± 1.24 | 6.05 ± 2.34 |
Creatinine (g/day) | ||||
Pre-intake | 0.94 ± 0.42 | 0.82 ± 0.33 | 1 ± 0.26 | 0.93 ± 0.28 |
4 weeks after first intake | 1.05 ± 0.37 | 0.93 ± 0.21 | 1.14 ± 0.27 | 1.13 ± 0.33 |
8 weeks after first intake | 1.18 ± 0.46 | 1.1 ± 0.22 | 1.28 ± 0.32 | 1.3 ± 0.24 |
12 weeks after first intake | 1.05 ± 0.47 | 1.17 ± 0.28 | 1.15 ± 0.26 | 1.1 ± 0.44 |
4 weeks after final intake | 1.11 ± 0.34 | 1.05 ± 0.39 | 1.18 ± 0.34 | 1.14 ± 0.45 |
Albumin (mg/g Cr) | ||||
Pre-intake | 2.1 ± 0.4 | 2.6 ± 1.7 | 1.9 ± 0.5 | 1.8 ± 0.5 |
4 weeks after first intake | 2.1 ± 1.1 | 2 ± 0.4 | 1.7 ± 0.5 | 1.8 ± 0.4 |
8 weeks after first intake | 1.9 ± 0.9 | 1.2 ± 0.3 | 1.7 ± 0.9 | 1.5 ± 0.7 |
12 weeks after first intake | 1.9 ± 0.9 | 1.5 ± 0.3 | 3 ± 4.5 | 1.6 ± 0.4 |
4 weeks after final intake | 3.5 ± 4.9 | 1.6 ± 0.4 | 1.5 ± 0.5 | 1.5 ± 0.3 |
Citric acid (mg/g Cr) | ||||
Pre-intake | 248.1 ± 209.2 | 244.4 ± 156.5 | 256.3 ± 228.3 | 212.7 ± 181.2 |
4 weeks after first intake | 244.6 ± 178.7 | 203.8 ± 137.4 | 226.2 ± 183.6 | 175.1 ± 132.4 |
8 weeks after first intake | 197.5 ± 142.2 | 180 ± 150.7 | 144.7 ± 114.5 | 134.9 ± 118.8 |
12 weeks after first intake | 228.7 ± 181.9 | 189.2 ± 142.2 | 164.6 ± 140.5 | 155.5 ± 146 |
4 weeks after final intake | 231.5 ± 176.9 | 190.6 ± 120.4 | 214.1 ± 179.6 | 165.5 ± 118.3 |
Hydroxyproline (μmol/day) | ||||
Pre-intake | 210 ± 89 | 200 ± 90 | 232 ± 65 | 194 ± 51 |
4 weeks after first intake | 218 ± 68 | 212 ± 48 | 256 ± 48 | 288 ± 86 |
8 weeks after first intake | 253 ± 96 | 244 ± 62 | 288 ± 72 | 364 ± 94* |
12 weeks after first intake | 207 ± 103 | 241 ± 61 | 263 ± 93 | 263 ± 80 |
4 weeks after final intake | 236 ± 88 | 224 ± 90 | 246 ± 52 | 241 ± 74 |
Oxalic acid (mg/day) | ||||
Pre-intake | 15.1 ± 7 | 12 ± 4.5 | 15.6 ± 4.1 | 13.1 ± 2.4 |
4 weeks after first intake | 24.8 ± 7.8 | 21.5 ± 4.8 | 27.2 ± 5.6 | 32.6 ± 8.7 |
8 weeks after first intake | 17.3 ± 4.6 | 17 ± 4.2 | 21.5 ± 6.8 | 24.7 ± 3.7* |
12 weeks after first intake | 19.2 ± 7.7 | 23.7 ± 5.9 | 25.2 ± 5.1 | 27.1 ± 6.9* |
4 weeks after final intake | 18.1 ± 6.4 | 17.5 ± 6.6 | 18.7 ± 4.7 | 16.3 ± 6.3 |
Open Access 01.06.2015 | Letter to the Editor
A single-blind, parallel trial of l-hydroxyproline in healthy adult subjects
Erschienen in: Urolithiasis | Ausgabe 3/2015