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Pediatric Cardiology

Erschienen in:

01.07.2009 | Riley Symposium

Insights into the Characteristics of Mammalian Cardiomyocyte Terminal Differentiation Shown Through the Study of Mice with a Dysfunctional c-Kit

verfasst von: Nawazish Naqvi, Ming Li, Eiji Yahiro, Robert M. Graham, Ahsan Husain

Erschienen in: Pediatric Cardiology | Ausgabe 5/2009

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Abstract

Mammalian cardiomyocytes withdraw from the cell cycle soon after birth. This process is called terminal differentiation. The c-kit, a receptor tyrosine kinase, is expressed on cardiomyocytes immediately after birth but for only a few days. In mice with genetic c-kit dysfunction, adult cardiomyocytes are phenotypically indistinguishable from those of wild type mice, except that they are capable of proliferation in vivo after acute pressure overload. This review explores the idea that postnatal cardiomyocyte differentiation and cell cycle withdrawal are distinct processes and that terminal differentiation may not simply be due to altered expression of genes that regulate the cell cycle but could involve c-kit induced epigenetic change.

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Titel: Insights into the Characteristics of Mammalian Cardiomyocyte Terminal Differentiation Shown Through the Study of Mice with a Dysfunctional c-Kit
verfasst von: Nawazish Naqvi
Ming Li
Eiji Yahiro
Robert M. Graham
Ahsan Husain
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: Pediatric Cardiology / Ausgabe 5/2009
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-008-9366-1

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