Skip to main content
Erschienen in: Pediatric Radiology 12/2021

12.05.2021 | Contrast-enhanced ultrasound (CEUS) in children

Contrast-enhanced ultrasound of transplant organs — liver and kidney — in children

verfasst von: Doris Franke, Reza J. Daugherty, Damjana Ključevšek, Aikaterini Ntoulia, Vasileios Rafailidis, Marcelo S. Takahashi, Alvaro Torres, Bernarda Viteri, Frank M. Volberg

Erschienen in: Pediatric Radiology | Ausgabe 12/2021

Einloggen, um Zugang zu erhalten

Abstract

Ultrasound (US) is the first-line imaging tool for evaluating liver and kidney transplants during and after the surgical procedures. In most patients after organ transplantation, gray-scale US coupled with color/power and spectral Doppler techniques is used to evaluate the transplant organs, assess the patency of vascular structures, and identify potential complications. In technically difficult or inconclusive cases, however, contrast-enhanced ultrasound (CEUS) can provide prompt and accurate diagnostic information that is essential for management decisions. CEUS is indicated to evaluate for vascular complications including vascular stenosis or thrombosis, active bleeding, pseudoaneurysms and arteriovenous fistulas. Parenchymal indications for CEUS include evaluation for perfusion defects and focal inflammatory and non-inflammatory lesions. When transplant rejection is suspected, CEUS can assist with prompt intervention by excluding potential underlying causes for organ dysfunction. Intracavitary CEUS applications can evaluate the biliary tract of a liver transplant (e.g., for biliary strictures, bile leak or intraductal stones) or the urinary tract of a renal transplant (e.g., for urinary obstruction, urine leak or vesicoureteral reflux) as well as the position and patency of hepatic, biliary and renal drains and catheters. The aim of this review is to present current experience regarding the use of CEUS to evaluate liver and renal transplants, focusing on the examination technique and interpretation of the main imaging findings, predominantly those related to vascular complications.
Literatur
1.
Zurück zum Zitat Piardi T, Lhuaire M, Bruno O et al (2016) Vascular complications following liver transplantation: a literature review of advances in 2015. World J Hepatol 8:36–57PubMedPubMedCentralCrossRef Piardi T, Lhuaire M, Bruno O et al (2016) Vascular complications following liver transplantation: a literature review of advances in 2015. World J Hepatol 8:36–57PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Nixon JN, Biyyam DR, Stanescu L et al (2013) Imaging of pediatric renal transplants and their complications: a pictorial review. Radiographics 33:1227–1251PubMedCrossRef Nixon JN, Biyyam DR, Stanescu L et al (2013) Imaging of pediatric renal transplants and their complications: a pictorial review. Radiographics 33:1227–1251PubMedCrossRef
3.
Zurück zum Zitat Friedewald SM, Molmenti EP, Friedewald JJ et al (2005) Vascular and nonvascular complications of renal transplants: sonographic evaluation and correlation with other imaging modalities, surgery, and pathology. J Clin Ultrasound 33:127–139PubMedCrossRef Friedewald SM, Molmenti EP, Friedewald JJ et al (2005) Vascular and nonvascular complications of renal transplants: sonographic evaluation and correlation with other imaging modalities, surgery, and pathology. J Clin Ultrasound 33:127–139PubMedCrossRef
4.
Zurück zum Zitat Camacho JC, Coursey-Moreno C, Telleria JC et al (2015) Nonvascular post-liver transplantation complications: from US screening to cross-sectional and interventional imaging. Radiographics 35:87–104PubMedCrossRef Camacho JC, Coursey-Moreno C, Telleria JC et al (2015) Nonvascular post-liver transplantation complications: from US screening to cross-sectional and interventional imaging. Radiographics 35:87–104PubMedCrossRef
5.
Zurück zum Zitat Kim N, Juarez R, Levy AD (2018) Imaging non-vascular complications of renal transplantation. Abdom Radiol 43:2555–2563CrossRef Kim N, Juarez R, Levy AD (2018) Imaging non-vascular complications of renal transplantation. Abdom Radiol 43:2555–2563CrossRef
7.
8.
Zurück zum Zitat Quiroga S, Sebastia MC, Margarit C et al (2001) Complications of orthotopic liver transplantation: spectrum of findings with helical CT. Radiographics 21:1085–1102PubMedCrossRef Quiroga S, Sebastia MC, Margarit C et al (2001) Complications of orthotopic liver transplantation: spectrum of findings with helical CT. Radiographics 21:1085–1102PubMedCrossRef
9.
Zurück zum Zitat Singh AK, Nachiappan AC, Verma HA et al (2010) Postoperative imaging in liver transplantation: what radiologists should know. Radiographics 30:339–351PubMedCrossRef Singh AK, Nachiappan AC, Verma HA et al (2010) Postoperative imaging in liver transplantation: what radiologists should know. Radiographics 30:339–351PubMedCrossRef
10.
Zurück zum Zitat Cordinha C, Rodrigues L, Carmo C et al (2019) Pediatric kidney transplantation: experience of a center over 4 decades. Transplant Proc 51:1579–1584PubMedCrossRef Cordinha C, Rodrigues L, Carmo C et al (2019) Pediatric kidney transplantation: experience of a center over 4 decades. Transplant Proc 51:1579–1584PubMedCrossRef
11.
Zurück zum Zitat Irtan S, Maisin A, Baudouin V et al (2010) Renal transplantation in children: critical analysis of age related surgical complications. Pediatr Transplant 14:512–519PubMedCrossRef Irtan S, Maisin A, Baudouin V et al (2010) Renal transplantation in children: critical analysis of age related surgical complications. Pediatr Transplant 14:512–519PubMedCrossRef
12.
Zurück zum Zitat Damasio MB, Ording Muller LS, Piaggio G et al (2017) Imaging in pediatric renal transplantation. Pediatr Transplant 21 Damasio MB, Ording Muller LS, Piaggio G et al (2017) Imaging in pediatric renal transplantation. Pediatr Transplant 21
13.
Zurück zum Zitat Abdelaziz O, Attia H (2016) Doppler ultrasonography in living donor liver transplantation recipients: intra- and post-operative vascular complications. World J Gastroenterol 22:6145–6172PubMedPubMedCentralCrossRef Abdelaziz O, Attia H (2016) Doppler ultrasonography in living donor liver transplantation recipients: intra- and post-operative vascular complications. World J Gastroenterol 22:6145–6172PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Hom BK, Shrestha R, Palmer SL et al (2006) Prospective evaluation of vascular complications after liver transplantation: comparison of conventional and microbubble contrast-enhanced US. Radiology 241:267–274PubMedCrossRef Hom BK, Shrestha R, Palmer SL et al (2006) Prospective evaluation of vascular complications after liver transplantation: comparison of conventional and microbubble contrast-enhanced US. Radiology 241:267–274PubMedCrossRef
15.
Zurück zum Zitat Zeisbrich M, Kihm LP, Druschler F et al (2015) When is contrast-enhanced sonography preferable over conventional ultrasound combined with Doppler imaging in renal transplantation? Clin Kidney J 8:606–614PubMedPubMedCentralCrossRef Zeisbrich M, Kihm LP, Druschler F et al (2015) When is contrast-enhanced sonography preferable over conventional ultrasound combined with Doppler imaging in renal transplantation? Clin Kidney J 8:606–614PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Rubenthaler J, Paprottka KJ, Hameister E et al (2017) Diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in monitoring vascular complications in patients after liver transplantation — diagnostic performance compared with histopathological results. Clin Hemorheol Microcirc 66:311–316PubMedCrossRef Rubenthaler J, Paprottka KJ, Hameister E et al (2017) Diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in monitoring vascular complications in patients after liver transplantation — diagnostic performance compared with histopathological results. Clin Hemorheol Microcirc 66:311–316PubMedCrossRef
17.
Zurück zum Zitat Teegen EM, Denecke T, Eisele R et al (2016) Clinical application of modern ultrasound techniques after liver transplantation. Acta Radiol 57:1161–1170PubMedCrossRef Teegen EM, Denecke T, Eisele R et al (2016) Clinical application of modern ultrasound techniques after liver transplantation. Acta Radiol 57:1161–1170PubMedCrossRef
18.
Zurück zum Zitat Rübenthaler J, Paprottka KJ, Hameister E et al (2016) Vascular complications in liver transplantation: beneficial role of contrast-enhanced ultrasound (CEUS) in the postoperative phase. Clin Hemorheol Microcirc 64:475–482PubMedCrossRef Rübenthaler J, Paprottka KJ, Hameister E et al (2016) Vascular complications in liver transplantation: beneficial role of contrast-enhanced ultrasound (CEUS) in the postoperative phase. Clin Hemorheol Microcirc 64:475–482PubMedCrossRef
19.
Zurück zum Zitat Ren J, Wu T, Zheng BW et al (2016) Application of contrast-enhanced ultrasound after liver transplantation: current status and perspectives. World J Gastroenterol 22:1607–1616PubMedPubMedCentralCrossRef Ren J, Wu T, Zheng BW et al (2016) Application of contrast-enhanced ultrasound after liver transplantation: current status and perspectives. World J Gastroenterol 22:1607–1616PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Mueller-Peltzer K, Negrao de Figueiredo G, Fischereder M et al (2018) Contrast-enhanced ultrasound (CEUS) as a new technique to characterize suspected renal transplant malignancies in renal transplant patients in comparison to standard imaging modalities. Clin Hemorheol Microcirc 69:69–75PubMedCrossRef Mueller-Peltzer K, Negrao de Figueiredo G, Fischereder M et al (2018) Contrast-enhanced ultrasound (CEUS) as a new technique to characterize suspected renal transplant malignancies in renal transplant patients in comparison to standard imaging modalities. Clin Hemorheol Microcirc 69:69–75PubMedCrossRef
21.
Zurück zum Zitat Morgan TA, Jha P, Poder L, Weinstein S (2018) Advanced ultrasound applications in the assessment of renal transplants: contrast-enhanced ultrasound, elastography, and B-flow. Abdom Radiol 43:2604–2614CrossRef Morgan TA, Jha P, Poder L, Weinstein S (2018) Advanced ultrasound applications in the assessment of renal transplants: contrast-enhanced ultrasound, elastography, and B-flow. Abdom Radiol 43:2604–2614CrossRef
22.
Zurück zum Zitat Mueller-Peltzer K, Rubenthaler J, Fischereder M et al (2017) The diagnostic value of contrast-enhanced ultrasound (CEUS) as a new technique for imaging of vascular complications in renal transplants compared to standard imaging modalities. Clin Hemorheol Microcirc 67:407–413PubMedCrossRef Mueller-Peltzer K, Rubenthaler J, Fischereder M et al (2017) The diagnostic value of contrast-enhanced ultrasound (CEUS) as a new technique for imaging of vascular complications in renal transplants compared to standard imaging modalities. Clin Hemorheol Microcirc 67:407–413PubMedCrossRef
23.
Zurück zum Zitat Alvarez Rodriguez S, Hevia Palacios V, Sanz Mayayo E et al (2017) The usefulness of contrast-enhanced ultrasound in the assessment of early kidney transplant function and complications. Diagnostics 7:53PubMedCentralCrossRef Alvarez Rodriguez S, Hevia Palacios V, Sanz Mayayo E et al (2017) The usefulness of contrast-enhanced ultrasound in the assessment of early kidney transplant function and complications. Diagnostics 7:53PubMedCentralCrossRef
24.
Zurück zum Zitat Korda D, Deak PA, Kozma V et al (2016) Role of contrast-enhanced ultrasound in the follow-up of kidney transplant patients. Transplant Proc 48:2544–2547PubMedCrossRef Korda D, Deak PA, Kozma V et al (2016) Role of contrast-enhanced ultrasound in the follow-up of kidney transplant patients. Transplant Proc 48:2544–2547PubMedCrossRef
25.
Zurück zum Zitat Kessner R, Nakamoto DA, Kondray V et al (2019) Contrast-enhanced ultrasound guidance for interventional procedures. J Ultrasound Med 38:2541–2557PubMedCrossRef Kessner R, Nakamoto DA, Kondray V et al (2019) Contrast-enhanced ultrasound guidance for interventional procedures. J Ultrasound Med 38:2541–2557PubMedCrossRef
26.
Zurück zum Zitat Daneshi M, Yusuf GT, Fang C et al (2019) Contrast-enhanced ultrasound (CEUS) nephrostogram: utility and accuracy as an alternative to fluoroscopic imaging of the urinary tract. Clin Radiol 74:167.e9–167.e16 Daneshi M, Yusuf GT, Fang C et al (2019) Contrast-enhanced ultrasound (CEUS) nephrostogram: utility and accuracy as an alternative to fluoroscopic imaging of the urinary tract. Clin Radiol 74:167.e9–167.e16
27.
Zurück zum Zitat Yusuf GT, Fang C, Huang DY et al (2018) Endocavitary contrast enhanced ultrasound (CEUS): a novel problem solving technique. Insights Imaging 9:303–311PubMedPubMedCentralCrossRef Yusuf GT, Fang C, Huang DY et al (2018) Endocavitary contrast enhanced ultrasound (CEUS): a novel problem solving technique. Insights Imaging 9:303–311PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Chopra SS, Eisele R, Stelter L et al (2012) Contrast enhanced ultrasound cholangiography via T-tube following liver transplantation. Ann Transplant 17:108–112PubMed Chopra SS, Eisele R, Stelter L et al (2012) Contrast enhanced ultrasound cholangiography via T-tube following liver transplantation. Ann Transplant 17:108–112PubMed
29.
Zurück zum Zitat Cai R, Tao L, Liang W et al (2020) Application of contrast-enhanced sonography on the diagnosis of acute and chronic rejection after renal transplantation. Ultrasound Q 36:59–63PubMedCrossRef Cai R, Tao L, Liang W et al (2020) Application of contrast-enhanced sonography on the diagnosis of acute and chronic rejection after renal transplantation. Ultrasound Q 36:59–63PubMedCrossRef
30.
Zurück zum Zitat Cuenca AG, Kim HB, Vakili K (2017) Pediatric liver transplantation. Semin Pediatr Surg 26:217–223PubMedCrossRef Cuenca AG, Kim HB, Vakili K (2017) Pediatric liver transplantation. Semin Pediatr Surg 26:217–223PubMedCrossRef
31.
Zurück zum Zitat Kerkar N, Emre S (2007) Issues unique to pediatric liver transplantation. Clin Liver Dis 11:323–335PubMedCrossRef Kerkar N, Emre S (2007) Issues unique to pediatric liver transplantation. Clin Liver Dis 11:323–335PubMedCrossRef
33.
Zurück zum Zitat Muller SA, Schmied BM, Welsch T et al (2006) How to increase inflow in liver transplantation. Clin Transpl 20:85–92CrossRef Muller SA, Schmied BM, Welsch T et al (2006) How to increase inflow in liver transplantation. Clin Transpl 20:85–92CrossRef
34.
Zurück zum Zitat Chan T, DeGirolamo K, Chartier-Plante S, Buczkowski AK (2017) Comparison of three caval reconstruction techniques in orthotopic liver transplantation: a retrospective review. Am J Surg 213:943–949PubMedCrossRef Chan T, DeGirolamo K, Chartier-Plante S, Buczkowski AK (2017) Comparison of three caval reconstruction techniques in orthotopic liver transplantation: a retrospective review. Am J Surg 213:943–949PubMedCrossRef
35.
Zurück zum Zitat Itri JN, Heller MT, Tublin ME (2013) Hepatic transplantation: postoperative complications. Abdom Imaging 38:1300–1333PubMedCrossRef Itri JN, Heller MT, Tublin ME (2013) Hepatic transplantation: postoperative complications. Abdom Imaging 38:1300–1333PubMedCrossRef
36.
Zurück zum Zitat Broering DC, Schulte am Esch J, Fischer L, Rogiers X (2004) Split liver transplantation. HPB 6:76–82 Broering DC, Schulte am Esch J, Fischer L, Rogiers X (2004) Split liver transplantation. HPB 6:76–82
37.
Zurück zum Zitat Liu CL, Lo CM, Fan ST (2005) What is the best technique for right hemiliver living donor liver transplantation? With or without the middle hepatic vein? Duct-to-duct biliary anastomosis or Roux-en-Y hepaticojejunostomy? J Hepatol 43:17–22PubMedCrossRef Liu CL, Lo CM, Fan ST (2005) What is the best technique for right hemiliver living donor liver transplantation? With or without the middle hepatic vein? Duct-to-duct biliary anastomosis or Roux-en-Y hepaticojejunostomy? J Hepatol 43:17–22PubMedCrossRef
38.
Zurück zum Zitat Verghese PS (2017) Pediatric kidney transplantation: a historical review. Pediatr Res 81:259–264PubMedCrossRef Verghese PS (2017) Pediatric kidney transplantation: a historical review. Pediatr Res 81:259–264PubMedCrossRef
39.
Zurück zum Zitat Hebert SA, Swinford RD, Hall DR et al (2017) Special considerations in pediatric kidney transplantation. Adv Chronic Kidney Dis 24:398–404PubMedCrossRef Hebert SA, Swinford RD, Hall DR et al (2017) Special considerations in pediatric kidney transplantation. Adv Chronic Kidney Dis 24:398–404PubMedCrossRef
40.
Zurück zum Zitat Wu F, Deng Z, Consigliere D, Tiong HY (2012) Synchronous nephrectomy with unilateral dual kidney transplantation: feasibility in patients with adult polycystic kidney disease. Singap Med J 53:e163–e165 Wu F, Deng Z, Consigliere D, Tiong HY (2012) Synchronous nephrectomy with unilateral dual kidney transplantation: feasibility in patients with adult polycystic kidney disease. Singap Med J 53:e163–e165
41.
Zurück zum Zitat Roach JP, Bock ME, Goebel J (2017) Pediatric kidney transplantation. Semin Pediatr Surg 26:233–240PubMedCrossRef Roach JP, Bock ME, Goebel J (2017) Pediatric kidney transplantation. Semin Pediatr Surg 26:233–240PubMedCrossRef
42.
Zurück zum Zitat Baumgarten HD, Rasmussen SK (2018) Technical aspects of kidney transplant and salvage procedures for technical complications in the child. In: Dunn SP, Horslen S (eds) Solid organ transplantation in infants and children. Springer International, Cham, pp 375–382CrossRef Baumgarten HD, Rasmussen SK (2018) Technical aspects of kidney transplant and salvage procedures for technical complications in the child. In: Dunn SP, Horslen S (eds) Solid organ transplantation in infants and children. Springer International, Cham, pp 375–382CrossRef
43.
Zurück zum Zitat Mwipatayi BP, Leong CW, Subramanian P, Picardo A (2013) En bloc kidney transplant from an 18-month-old donor to an adult recipient: case report and literature review. Int J Surg Case Rep 4:948–951PubMedPubMedCentralCrossRef Mwipatayi BP, Leong CW, Subramanian P, Picardo A (2013) En bloc kidney transplant from an 18-month-old donor to an adult recipient: case report and literature review. Int J Surg Case Rep 4:948–951PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Torres A, Koskinen SK, Gjertsen H, Fischler B (2018) Contrast-enhanced ultrasound for identifying circulatory complications after liver transplants in children. Pediatr Transplant 23:e13327PubMedCrossRef Torres A, Koskinen SK, Gjertsen H, Fischler B (2018) Contrast-enhanced ultrasound for identifying circulatory complications after liver transplants in children. Pediatr Transplant 23:e13327PubMedCrossRef
45.
Zurück zum Zitat Bonini G, Pezzotta G, Morzenti C et al (2007) Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound 10:99–106PubMedPubMedCentralCrossRef Bonini G, Pezzotta G, Morzenti C et al (2007) Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound 10:99–106PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat Putz FJ, Erlmeier A, Wiesinger I et al (2017) Contrast-enhanced ultrasound (CEUS) in renal imaging at an interdisciplinary ultrasound centre: possibilities of dynamic microvascularisation and perfusion. Clin Hemorheol Microcirc 66:293–302PubMedCrossRef Putz FJ, Erlmeier A, Wiesinger I et al (2017) Contrast-enhanced ultrasound (CEUS) in renal imaging at an interdisciplinary ultrasound centre: possibilities of dynamic microvascularisation and perfusion. Clin Hemorheol Microcirc 66:293–302PubMedCrossRef
47.
Zurück zum Zitat Girometti R, Stocca T, Serena E et al (2017) Impact of contrast-enhanced ultrasound in patients with renal function impairment. World J Radiol 9:10–16PubMedPubMedCentralCrossRef Girometti R, Stocca T, Serena E et al (2017) Impact of contrast-enhanced ultrasound in patients with renal function impairment. World J Radiol 9:10–16PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Eisenbrey JR, Daecher A, Kramer MR, Forsberg F (2015) Effects of needle and catheter size on commercially available ultrasound contrast agents. J Ultrasound Med 34:1961–1968PubMedCrossRef Eisenbrey JR, Daecher A, Kramer MR, Forsberg F (2015) Effects of needle and catheter size on commercially available ultrasound contrast agents. J Ultrasound Med 34:1961–1968PubMedCrossRef
49.
Zurück zum Zitat Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef
50.
Zurück zum Zitat Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med 34:11–29PubMedCrossRef Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med 34:11–29PubMedCrossRef
51.
Zurück zum Zitat Jang HY, Kim KW, Kim SY et al (2018) Visibility of the graft hepatic artery using superb microvascular imaging in liver transplantation recipients: initial experience. Acta Radiol 59:1326–1335PubMedCrossRef Jang HY, Kim KW, Kim SY et al (2018) Visibility of the graft hepatic artery using superb microvascular imaging in liver transplantation recipients: initial experience. Acta Radiol 59:1326–1335PubMedCrossRef
52.
Zurück zum Zitat Bekker J, Ploem S, de Jong KP (2009) Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risk factors. Am J Transplant 9:746–757PubMedCrossRef Bekker J, Ploem S, de Jong KP (2009) Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risk factors. Am J Transplant 9:746–757PubMedCrossRef
53.
Zurück zum Zitat Pareja E, Cortes M, Navarro R et al (2010) Vascular complications after orthotopic liver transplantation: hepatic artery thrombosis. Transplant Proc 42:2970–2972PubMedCrossRef Pareja E, Cortes M, Navarro R et al (2010) Vascular complications after orthotopic liver transplantation: hepatic artery thrombosis. Transplant Proc 42:2970–2972PubMedCrossRef
54.
Zurück zum Zitat Tan KC, Yandza T, de Hemptinne B et al (1988) Hepatic artery thrombosis in pediatric liver transplantation. J Pediatr Surg 23:927–930PubMedCrossRef Tan KC, Yandza T, de Hemptinne B et al (1988) Hepatic artery thrombosis in pediatric liver transplantation. J Pediatr Surg 23:927–930PubMedCrossRef
55.
Zurück zum Zitat Diamond IR, Fecteau A, Millis JM et al (2007) Impact of graft type on outcome in pediatric liver transplantation: a report from studies of pediatric liver transplantation (SPLIT). Ann Surg 246:301–310PubMedPubMedCentralCrossRef Diamond IR, Fecteau A, Millis JM et al (2007) Impact of graft type on outcome in pediatric liver transplantation: a report from studies of pediatric liver transplantation (SPLIT). Ann Surg 246:301–310PubMedPubMedCentralCrossRef
56.
Zurück zum Zitat Sanyal R, Lall CG, Lamba R et al (2012) Orthotopic liver transplantation: reversible Doppler US findings in the immediate postoperative period. Radiographics 32:199–211PubMedCrossRef Sanyal R, Lall CG, Lamba R et al (2012) Orthotopic liver transplantation: reversible Doppler US findings in the immediate postoperative period. Radiographics 32:199–211PubMedCrossRef
57.
Zurück zum Zitat Marshall MM, Muiesan P, Srinivasan P et al (2001) Hepatic artery pseudoaneurysms following liver transplantation: incidence, presenting features and management. Clin Radiol 56:579–587PubMedCrossRef Marshall MM, Muiesan P, Srinivasan P et al (2001) Hepatic artery pseudoaneurysms following liver transplantation: incidence, presenting features and management. Clin Radiol 56:579–587PubMedCrossRef
58.
Zurück zum Zitat Ma L, Chen K, Lu Q et al (2016) Case report of hepatic artery dissection secondary to hepatic artery pseudoaneurysm after living donor liver transplantation. BMC Gastroenterol 16:44PubMedPubMedCentralCrossRef Ma L, Chen K, Lu Q et al (2016) Case report of hepatic artery dissection secondary to hepatic artery pseudoaneurysm after living donor liver transplantation. BMC Gastroenterol 16:44PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Ren X, Luo Y, Gao N et al (2016) Common ultrasound and contrast-enhanced ultrasonography in the diagnosis of hepatic artery pseudoaneurysm after liver transplantation. Exp Ther Med 12:1029–1033PubMedPubMedCentralCrossRef Ren X, Luo Y, Gao N et al (2016) Common ultrasound and contrast-enhanced ultrasonography in the diagnosis of hepatic artery pseudoaneurysm after liver transplantation. Exp Ther Med 12:1029–1033PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Glockner JF, Forauer AR (1999) Vascular or ischemic complications after liver transplantation. AJR Am J Roentgenol 173:1055–1059PubMedCrossRef Glockner JF, Forauer AR (1999) Vascular or ischemic complications after liver transplantation. AJR Am J Roentgenol 173:1055–1059PubMedCrossRef
61.
Zurück zum Zitat Franke D, Riccabona M (2015) Doppler sonography of the liver in infants and children. In: Deeg K-H, Rupprecht T, Hofbeck M (eds) Doppler sonography in infancy and childhood. Springer, Cham, pp 311–377 Franke D, Riccabona M (2015) Doppler sonography of the liver in infants and children. In: Deeg K-H, Rupprecht T, Hofbeck M (eds) Doppler sonography in infancy and childhood. Springer, Cham, pp 311–377
62.
Zurück zum Zitat Liu X, Jang HJ, Khalili K et al (2018) Successful integration of contrast-enhanced US into routine abdominal imaging. Radiographics 38:1454–1477PubMedCrossRef Liu X, Jang HJ, Khalili K et al (2018) Successful integration of contrast-enhanced US into routine abdominal imaging. Radiographics 38:1454–1477PubMedCrossRef
63.
Zurück zum Zitat Karakayali F, Kirnap M, Akdur A et al (2013) Biliary complications after pediatric liver transplantation. Transplant Proc 45:3524–3527PubMedCrossRef Karakayali F, Kirnap M, Akdur A et al (2013) Biliary complications after pediatric liver transplantation. Transplant Proc 45:3524–3527PubMedCrossRef
64.
Zurück zum Zitat Fontanilla T, Noblejas A, Cortes C et al (2013) Contrast-enhanced ultrasound of liver lesions related to arterial thrombosis in adult liver transplantation. J Clin Ultrasound 41:493–500PubMedCrossRef Fontanilla T, Noblejas A, Cortes C et al (2013) Contrast-enhanced ultrasound of liver lesions related to arterial thrombosis in adult liver transplantation. J Clin Ultrasound 41:493–500PubMedCrossRef
65.
Zurück zum Zitat Pan FS, Liu M, Luo J et al (2017) Transplant renal artery stenosis: evaluation with contrast-enhanced ultrasound. Eur J Radiol 90:42–49PubMedCrossRef Pan FS, Liu M, Luo J et al (2017) Transplant renal artery stenosis: evaluation with contrast-enhanced ultrasound. Eur J Radiol 90:42–49PubMedCrossRef
66.
Zurück zum Zitat Yang C, Wu S, Yang P et al (2019) Prediction of renal allograft chronic rejection using a model based on contrast-enhanced ultrasonography. Microcirculation 26:e12544PubMedPubMedCentralCrossRef Yang C, Wu S, Yang P et al (2019) Prediction of renal allograft chronic rejection using a model based on contrast-enhanced ultrasonography. Microcirculation 26:e12544PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Deeg K-H (2015) Renal circulation. In: Deeg K-H, Rupprecht T, Hofbeck M (eds) Doppler sonography in infancy and childhood. Springer, Cham, pp 489–566 Deeg K-H (2015) Renal circulation. In: Deeg K-H, Rupprecht T, Hofbeck M (eds) Doppler sonography in infancy and childhood. Springer, Cham, pp 489–566
68.
Zurück zum Zitat Grabner A, Kentrup D, Pawelski H et al (2016) Renal contrast-enhanced sonography findings in a model of acute cellular allograft rejection. Am J Transplant 16:1612–1619PubMedCrossRef Grabner A, Kentrup D, Pawelski H et al (2016) Renal contrast-enhanced sonography findings in a model of acute cellular allograft rejection. Am J Transplant 16:1612–1619PubMedCrossRef
69.
Zurück zum Zitat Mueller-Peltzer K, Negrao de Figueiredo G, Fischereder M et al (2018) Vascular rejection in renal transplant: diagnostic value of contrast-enhanced ultrasound (CEUS) compared to biopsy. Clin Hemorheol Microcirc 69:77–82PubMedCrossRef Mueller-Peltzer K, Negrao de Figueiredo G, Fischereder M et al (2018) Vascular rejection in renal transplant: diagnostic value of contrast-enhanced ultrasound (CEUS) compared to biopsy. Clin Hemorheol Microcirc 69:77–82PubMedCrossRef
70.
Zurück zum Zitat Grzelak P, Kurnatowska I, Nowicki M et al (2012) Standard B presentation vs. contrast-enhanced ultrasound (US-CE). A comparison of usefulness of different ultrasonographic techniques in the evaluation of the echo structure and size of haematomas in post-renal transplant patients: a preliminary report. Pol J Radiol 77:14–18 Grzelak P, Kurnatowska I, Nowicki M et al (2012) Standard B presentation vs. contrast-enhanced ultrasound (US-CE). A comparison of usefulness of different ultrasonographic techniques in the evaluation of the echo structure and size of haematomas in post-renal transplant patients: a preliminary report. Pol J Radiol 77:14–18
71.
Zurück zum Zitat Grzelak P, Kurnatowska I, Sapieha M et al (2011) Disturbances of kidney graft perfusion as indicators of acute renal vein thrombosis in contrast-enhanced ultrasonography. Transplant Proc 43:3018–3020PubMedCrossRef Grzelak P, Kurnatowska I, Sapieha M et al (2011) Disturbances of kidney graft perfusion as indicators of acute renal vein thrombosis in contrast-enhanced ultrasonography. Transplant Proc 43:3018–3020PubMedCrossRef
72.
Zurück zum Zitat Fischer T, Muhler M, Kroncke TJ et al (2004) Early postoperative ultrasound of kidney transplants: evaluation of contrast medium dynamics using time-intensity curves. Rofo 176:472–477PubMedCrossRef Fischer T, Muhler M, Kroncke TJ et al (2004) Early postoperative ultrasound of kidney transplants: evaluation of contrast medium dynamics using time-intensity curves. Rofo 176:472–477PubMedCrossRef
73.
Zurück zum Zitat Lebkowska U, Janica J, Lebkowski W et al (2009) Renal parenchyma perfusion spectrum and resistive index (RI) in ultrasound examinations with contrast medium in the early period after kidney transplantation. Transplant Proc 41:3024–3027PubMedCrossRef Lebkowska U, Janica J, Lebkowski W et al (2009) Renal parenchyma perfusion spectrum and resistive index (RI) in ultrasound examinations with contrast medium in the early period after kidney transplantation. Transplant Proc 41:3024–3027PubMedCrossRef
74.
Zurück zum Zitat Benozzi L, Cappelli G, Granito M et al (2009) Contrast-enhanced sonography in early kidney graft dysfunction. Transplant Proc 41:1214–1215PubMedCrossRef Benozzi L, Cappelli G, Granito M et al (2009) Contrast-enhanced sonography in early kidney graft dysfunction. Transplant Proc 41:1214–1215PubMedCrossRef
75.
Zurück zum Zitat Araújo NC, Suassuna JHR (2018) Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period — a prospective study. BMC Nephrol 19:351PubMedPubMedCentralCrossRef Araújo NC, Suassuna JHR (2018) Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period — a prospective study. BMC Nephrol 19:351PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Grzelak P, Szymczyk K, Strzelczyk J et al (2011) Perfusion of kidney graft pyramids and cortex in contrast-enhanced ultrasonography in the determination of the cause of delayed graft function. Ann Transplant 16:48–53PubMedCrossRef Grzelak P, Szymczyk K, Strzelczyk J et al (2011) Perfusion of kidney graft pyramids and cortex in contrast-enhanced ultrasonography in the determination of the cause of delayed graft function. Ann Transplant 16:48–53PubMedCrossRef
77.
Zurück zum Zitat Schwenger V, Hankel V, Seckinger J et al (2014) Contrast-enhanced ultrasonography in the early period after kidney transplantation predicts long-term allograft function. Transplant Proc 46:3352–3357PubMedCrossRef Schwenger V, Hankel V, Seckinger J et al (2014) Contrast-enhanced ultrasonography in the early period after kidney transplantation predicts long-term allograft function. Transplant Proc 46:3352–3357PubMedCrossRef
78.
Zurück zum Zitat Jin Y, Yang C, Wu S et al (2015) A novel simple noninvasive index to predict renal transplant acute rejection by contrast-enhanced ultrasonography. Transplantation 99:636–641PubMedCrossRef Jin Y, Yang C, Wu S et al (2015) A novel simple noninvasive index to predict renal transplant acute rejection by contrast-enhanced ultrasonography. Transplantation 99:636–641PubMedCrossRef
79.
Zurück zum Zitat Wang X, Yu Z, Guo R et al (2015) Assessment of postoperative perfusion with contrast-enhanced ultrasonography in kidney transplantation. Int J Clin Exp Med 8:18399–18405PubMedPubMedCentral Wang X, Yu Z, Guo R et al (2015) Assessment of postoperative perfusion with contrast-enhanced ultrasonography in kidney transplantation. Int J Clin Exp Med 8:18399–18405PubMedPubMedCentral
80.
Zurück zum Zitat Paudice N, Zanazzi M, Agostini S et al (2012) Contrast-enhanced ultrasound assessment of complex cystic lesions in renal transplant recipients with acquired cystic kidney disease: preliminary experience. Transplant Proc 44:1928–1929PubMedCrossRef Paudice N, Zanazzi M, Agostini S et al (2012) Contrast-enhanced ultrasound assessment of complex cystic lesions in renal transplant recipients with acquired cystic kidney disease: preliminary experience. Transplant Proc 44:1928–1929PubMedCrossRef
81.
Zurück zum Zitat Helck A, Sommer WH, Wessely M et al (2011) Benefit of contrast enhanced ultrasound for detection of ischaemic lesions and arterio venous fistulas in renal transplants — a feasibility study. Clin Hemorheol Microcirc 48:149–160PubMedCrossRef Helck A, Sommer WH, Wessely M et al (2011) Benefit of contrast enhanced ultrasound for detection of ischaemic lesions and arterio venous fistulas in renal transplants — a feasibility study. Clin Hemorheol Microcirc 48:149–160PubMedCrossRef
82.
Zurück zum Zitat Grzelak P, Sapieha M, Kurnatowska I et al (2011) Contrast-enhanced sonography of postbiopsy arteriovenous fistulas in kidney grafts. J Clin Ultrasound 39:378–382PubMedCrossRef Grzelak P, Sapieha M, Kurnatowska I et al (2011) Contrast-enhanced sonography of postbiopsy arteriovenous fistulas in kidney grafts. J Clin Ultrasound 39:378–382PubMedCrossRef
83.
Zurück zum Zitat Granata A, Andrulli S, Fiorini F et al (2011) Diagnosis of acute pyelonephritis by contrast-enhanced ultrasonography in kidney transplant patients. Nephrol Dial Transplant 26:715–720PubMedCrossRef Granata A, Andrulli S, Fiorini F et al (2011) Diagnosis of acute pyelonephritis by contrast-enhanced ultrasonography in kidney transplant patients. Nephrol Dial Transplant 26:715–720PubMedCrossRef
84.
Zurück zum Zitat Harvey CJ, Alsafi A, Kuzmich S et al (2015) Role of US contrast agents in the assessment of indeterminate solid and cystic lesions in native and transplant kidneys. Radiographics 35:1419–1430PubMedCrossRef Harvey CJ, Alsafi A, Kuzmich S et al (2015) Role of US contrast agents in the assessment of indeterminate solid and cystic lesions in native and transplant kidneys. Radiographics 35:1419–1430PubMedCrossRef
85.
Zurück zum Zitat Kljucevsek D, Riccabona M, Ording Muller LS et al (2020) Intracavitary contrast-enhanced ultrasonography in children: review with procedural recommendations and clinical applications from the European Society of Paediatric Radiology abdominal imaging task force. Pediatr Radiol 50:596–606PubMedCrossRef Kljucevsek D, Riccabona M, Ording Muller LS et al (2020) Intracavitary contrast-enhanced ultrasonography in children: review with procedural recommendations and clinical applications from the European Society of Paediatric Radiology abdominal imaging task force. Pediatr Radiol 50:596–606PubMedCrossRef
86.
Zurück zum Zitat Hoeffel C, Azizi L, Lewin M et al (2006) Normal and pathologic features of the postoperative biliary tract at 3D MR cholangiopancreatography and MR imaging. Radiographics 26:1603–1620PubMedCrossRef Hoeffel C, Azizi L, Lewin M et al (2006) Normal and pathologic features of the postoperative biliary tract at 3D MR cholangiopancreatography and MR imaging. Radiographics 26:1603–1620PubMedCrossRef
87.
Zurück zum Zitat Darge K (2010) Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update. Pediatr Radiol 40:956–962PubMedCrossRef Darge K (2010) Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update. Pediatr Radiol 40:956–962PubMedCrossRef
88.
Zurück zum Zitat Darge K (2008) Voiding urosonography with ultrasound contrast agents for the diagnosis of vesicoureteric reflux in children. I. Procedure. Pediatr Radiol 38:40–53PubMedCrossRef Darge K (2008) Voiding urosonography with ultrasound contrast agents for the diagnosis of vesicoureteric reflux in children. I. Procedure. Pediatr Radiol 38:40–53PubMedCrossRef
89.
Zurück zum Zitat Huang DY, Yusuf GT, Daneshi M et al (2017) Contrast-enhanced US-guided interventions: improving success rate and avoiding complications using US contrast agents. Radiographics 37:652–664PubMedCrossRef Huang DY, Yusuf GT, Daneshi M et al (2017) Contrast-enhanced US-guided interventions: improving success rate and avoiding complications using US contrast agents. Radiographics 37:652–664PubMedCrossRef
90.
Zurück zum Zitat Lu Q, Zhong XF, Huang ZX et al (2012) Role of contrast-enhanced ultrasound in decision support for diagnosis and treatment of hepatic artery thrombosis after liver transplantation. Eur J Radiol 81:e338–e343PubMedCrossRef Lu Q, Zhong XF, Huang ZX et al (2012) Role of contrast-enhanced ultrasound in decision support for diagnosis and treatment of hepatic artery thrombosis after liver transplantation. Eur J Radiol 81:e338–e343PubMedCrossRef
91.
Zurück zum Zitat Berstad AE, Brabrand K, Foss A (2009) Clinical utility of microbubble contrast-enhanced ultrasound in the diagnosis of hepatic artery occlusion after liver transplantation. Transpl Int 22:954–960PubMedCrossRef Berstad AE, Brabrand K, Foss A (2009) Clinical utility of microbubble contrast-enhanced ultrasound in the diagnosis of hepatic artery occlusion after liver transplantation. Transpl Int 22:954–960PubMedCrossRef
92.
Zurück zum Zitat Sidhu PS, Shaw AS, Ellis SM et al (2004) Microbubble ultrasound contrast in the assessment of hepatic artery patency following liver transplantation: role in reducing frequency of hepatic artery arteriography. Eur Radiol 14:21–30PubMedCrossRef Sidhu PS, Shaw AS, Ellis SM et al (2004) Microbubble ultrasound contrast in the assessment of hepatic artery patency following liver transplantation: role in reducing frequency of hepatic artery arteriography. Eur Radiol 14:21–30PubMedCrossRef
93.
Zurück zum Zitat Zheng RQ, Mao R, Ren J et al (2010) Contrast-enhanced ultrasound for the evaluation of hepatic artery stenosis after liver transplantation: potential role in changing the clinical algorithm. Liver Transpl 16:729–735PubMedCrossRef Zheng RQ, Mao R, Ren J et al (2010) Contrast-enhanced ultrasound for the evaluation of hepatic artery stenosis after liver transplantation: potential role in changing the clinical algorithm. Liver Transpl 16:729–735PubMedCrossRef
94.
Zurück zum Zitat Park YS, Kim KW, Kim SY et (2012) Obstruction at middle hepatic venous tributaries in modified right lobe grafts after living-donor liver transplantation: diagnosis with contrast-enhanced US. Radiology 265:617–626 Park YS, Kim KW, Kim SY et (2012) Obstruction at middle hepatic venous tributaries in modified right lobe grafts after living-donor liver transplantation: diagnosis with contrast-enhanced US. Radiology 265:617–626
95.
Zurück zum Zitat Rennert J, Dornia C, Georgieva M et al (2012) Identification of early complications following liver transplantation using contrast enhanced ultrasound (CEUS). First results J Gastrointestin Liver Dis 21:407–412PubMed Rennert J, Dornia C, Georgieva M et al (2012) Identification of early complications following liver transplantation using contrast enhanced ultrasound (CEUS). First results J Gastrointestin Liver Dis 21:407–412PubMed
96.
Zurück zum Zitat Clevert DA, Stickel M, Minaifar N et al (2009) Contrast-enhanced ultrasound in liver transplant: first results and potential for complications in the postoperative period. Clin Hemorheol Microcirc 43:83–94PubMedCrossRef Clevert DA, Stickel M, Minaifar N et al (2009) Contrast-enhanced ultrasound in liver transplant: first results and potential for complications in the postoperative period. Clin Hemorheol Microcirc 43:83–94PubMedCrossRef
97.
Zurück zum Zitat Rübenthaler J, Paprottka KJ, Hameister E et al (2016) Malignancies after liver transplantation: value of contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc 64:467–473PubMedCrossRef Rübenthaler J, Paprottka KJ, Hameister E et al (2016) Malignancies after liver transplantation: value of contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc 64:467–473PubMedCrossRef
98.
Zurück zum Zitat Grzelak P, Kurnatowska I, Nowicki M et al (2013) Detection of transplant renal artery stenosis in the early postoperative period with analysis of parenchymal perfusion with ultrasound contrast agent. Ann Transplant 18:187–194PubMedCrossRef Grzelak P, Kurnatowska I, Nowicki M et al (2013) Detection of transplant renal artery stenosis in the early postoperative period with analysis of parenchymal perfusion with ultrasound contrast agent. Ann Transplant 18:187–194PubMedCrossRef
99.
Zurück zum Zitat Stenberg B, Chandler C, Wyrley-Birch H, Elliott ST (2014) Post-operative 3-dimensional contrast-enhanced ultrasound (CEUS) versus Tc99m-DTPA in the detection of post-surgical perfusion defects in kidney transplants — preliminary findings. Ultraschall Med 35:273–278PubMed Stenberg B, Chandler C, Wyrley-Birch H, Elliott ST (2014) Post-operative 3-dimensional contrast-enhanced ultrasound (CEUS) versus Tc99m-DTPA in the detection of post-surgical perfusion defects in kidney transplants — preliminary findings. Ultraschall Med 35:273–278PubMed
Metadaten
Titel
Contrast-enhanced ultrasound of transplant organs — liver and kidney — in children
verfasst von
Doris Franke
Reza J. Daugherty
Damjana Ključevšek
Aikaterini Ntoulia
Vasileios Rafailidis
Marcelo S. Takahashi
Alvaro Torres
Bernarda Viteri
Frank M. Volberg
Publikationsdatum
12.05.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe 12/2021
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-020-04867-y

Weitere Artikel der Ausgabe 12/2021

Pediatric Radiology 12/2021 Zur Ausgabe

Contrast-enhanced ultrasound (CEUS) in children

Contrast-enhanced ultrasound of the kidneys and adrenals in children

Contrast-enhanced ultrasound (CEUS) in children

Translational research in pediatric contrast-enhanced ultrasound

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.