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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 8/2006

01.08.2006 | Controversies

Is PET/CT necessary in paediatric oncology?

verfasst von: Christiane Franzius, Kai Uwe Juergens, Otmar Schober

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 8/2006

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Excerpt

The introduction of combined PET/CT into clinical practice has been greeted with much enthusiasm among nuclear medicine physicians, radiologists and oncologists. Since the first PET/CT scanners became available, many studies have demonstrated its clinical value in various tumour types (reviews in [1, 2]). The value of PET/CT in paediatric patients, however, has not been established. Case reports, pictorial essays and reports on feasibility and practical aspects have been published, but to date no studies have evaluated the diagnostic benefit of PET/CT in children [36]. A limited number of studies have evaluated the clinical usefulness of (FDG-)PET as a single modality in paediatric tumour entities. The need for such studies has been stressed by many authors [3, 68]. Nevertheless, it can already be anticipated that the combination of structural and metabolic information provided by integrated PET/CT will improve the accuracy of staging and will have the potential to change management in a significant number of paediatric patients, as has been demonstrated in adults (reviews in [2, 911]). …
Literatur
1.
Zurück zum Zitat Czernin J, Auerbach MA. Clinical PET/CT imaging. Nuklearmedizin 2005;44:18–23. Czernin J, Auerbach MA. Clinical PET/CT imaging. Nuklearmedizin 2005;44:18–23.
2.
Zurück zum Zitat Wechalekar K, Sharma B, Cook G. PET/CT in oncology—a major advance. Clin Radiol 2005;60:1143–55.PubMedCrossRef Wechalekar K, Sharma B, Cook G. PET/CT in oncology—a major advance. Clin Radiol 2005;60:1143–55.PubMedCrossRef
3.
Zurück zum Zitat Kaste S. Issues specific to implementing PET-CT for pediatric oncology: what have we learned along the way? Pediatr Radiol 2004;34:205–13.PubMedCrossRef Kaste S. Issues specific to implementing PET-CT for pediatric oncology: what have we learned along the way? Pediatr Radiol 2004;34:205–13.PubMedCrossRef
4.
Zurück zum Zitat McCarville MB, Christie R, Daw NC, Spunt SL, Kaste SC. PET/CT in evaluation of childhood sarcomas. Am J Roentgenol 2005;184:1293–304. McCarville MB, Christie R, Daw NC, Spunt SL, Kaste SC. PET/CT in evaluation of childhood sarcomas. Am J Roentgenol 2005;184:1293–304.
5.
Zurück zum Zitat Franzius C, Juergens KU, Vormoor J. PET/CT with diagnostic CT in the evaluation of childhood sarcoma. Am J Roentgenol 2006;186:581.CrossRef Franzius C, Juergens KU, Vormoor J. PET/CT with diagnostic CT in the evaluation of childhood sarcoma. Am J Roentgenol 2006;186:581.CrossRef
6.
Zurück zum Zitat Franzius C, Lang K, Wormanns D, Vormoor J, Schober O. PET/CT and PET—application in pediatric oncology. Der Nuklearmediziner 2004;27:315–323 Franzius C, Lang K, Wormanns D, Vormoor J, Schober O. PET/CT and PET—application in pediatric oncology. Der Nuklearmediziner 2004;27:315–323
7.
Zurück zum Zitat Herrmann S, Wormanns D, Pixberg M, Hunold A, Heindel WL, Jürgens H, et al. Staging in childhood lymphoma: differences between FDG-PET and CT. Nuklearmedizin 2005;44:1–7. Herrmann S, Wormanns D, Pixberg M, Hunold A, Heindel WL, Jürgens H, et al. Staging in childhood lymphoma: differences between FDG-PET and CT. Nuklearmedizin 2005;44:1–7.
8.
Zurück zum Zitat Körholz D, Clavies A, Hasenclever D, Kluge R, Hirsch W, Kamprad F, et al. The concept of the GPOH-HD 2003 therapy study for pediatric Hodgkin’s disease: evolution in the tradition of DAL/GPOH studies. Klin Pädiatr 2004;216:150–6.PubMedCrossRef Körholz D, Clavies A, Hasenclever D, Kluge R, Hirsch W, Kamprad F, et al. The concept of the GPOH-HD 2003 therapy study for pediatric Hodgkin’s disease: evolution in the tradition of DAL/GPOH studies. Klin Pädiatr 2004;216:150–6.PubMedCrossRef
9.
Zurück zum Zitat Bar-Shalom R, Yefremov N, Guralnik L, Gaitini D, Frenkel A, Kuten A, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 2003;44:1200–9.PubMed Bar-Shalom R, Yefremov N, Guralnik L, Gaitini D, Frenkel A, Kuten A, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 2003;44:1200–9.PubMed
10.
Zurück zum Zitat Yeung HWD, Schröder H, Smith A, Gonen M, Larson SML. Clinical value of combined positron emission tomography/computed tomography imaging in the interpretation of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography studies in cancer patients. Mol Imaging Biol 2005;7:229–35.PubMedCrossRef Yeung HWD, Schröder H, Smith A, Gonen M, Larson SML. Clinical value of combined positron emission tomography/computed tomography imaging in the interpretation of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography studies in cancer patients. Mol Imaging Biol 2005;7:229–35.PubMedCrossRef
11.
Zurück zum Zitat Blodgett TM, Casagranda B, Townsend DW, Meltzer CC. Issues, controversies, and clinical utility of combined PET/CT imaging: what is the interpreting physician facing? Am J Roentgenol 2005;184:138–45. Blodgett TM, Casagranda B, Townsend DW, Meltzer CC. Issues, controversies, and clinical utility of combined PET/CT imaging: what is the interpreting physician facing? Am J Roentgenol 2005;184:138–45.
12.
Zurück zum Zitat Brenner DJ, Elliston CD, Hall EJ, Berdon WE. Estimated risks of radiation-induced fatal cancer from pediatric CT. Am J Roentgenol 2001;176:286–96. Brenner DJ, Elliston CD, Hall EJ, Berdon WE. Estimated risks of radiation-induced fatal cancer from pediatric CT. Am J Roentgenol 2001;176:286–96.
13.
Zurück zum Zitat Honnef D, Wildberger JE, Stargardt A, Hohl C, Barker M, Günther RW, et al. Multislice spiral CT (MSCT) in pediatric radiology: dose reduction for chest and abdomen examinations. Fortschr Röntgenstr 2004;176:1021–30.CrossRef Honnef D, Wildberger JE, Stargardt A, Hohl C, Barker M, Günther RW, et al. Multislice spiral CT (MSCT) in pediatric radiology: dose reduction for chest and abdomen examinations. Fortschr Röntgenstr 2004;176:1021–30.CrossRef
14.
Zurück zum Zitat Lang K, Vormoor J, Weckesser M, Schober O, Franzius C. PET-CT in pediatric patients: analysis of 175 whole body scans. Eur J Nucl Med Mol Imaging 2005;32 Suppl 1:154. Lang K, Vormoor J, Weckesser M, Schober O, Franzius C. PET-CT in pediatric patients: analysis of 175 whole body scans. Eur J Nucl Med Mol Imaging 2005;32 Suppl 1:154.
15.
Zurück zum Zitat Messa C, Bettinardi V, Picchio M, Pelosi E, Landoni C, Gianolli L, et al. PET/CT in diagnostic oncology. Q J Nucl Med 2004;48:75–86. Messa C, Bettinardi V, Picchio M, Pelosi E, Landoni C, Gianolli L, et al. PET/CT in diagnostic oncology. Q J Nucl Med 2004;48:75–86.
16.
Zurück zum Zitat Osman MM, Cohade C, Fishman EK, Wahl RL. Clinically significant incidental findings on the unenhanced CT portion of PET/CT studies: frequency in 250 patients. J Nucl Med 2005;46:1352–5.PubMed Osman MM, Cohade C, Fishman EK, Wahl RL. Clinically significant incidental findings on the unenhanced CT portion of PET/CT studies: frequency in 250 patients. J Nucl Med 2005;46:1352–5.PubMed
17.
Zurück zum Zitat Coleman RE, Delbeke D, Guiberteau MJ, Conti PS, Royal H, Weinreb JC, et al. Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance. J Nucl Med 2005;46:1225–39.PubMed Coleman RE, Delbeke D, Guiberteau MJ, Conti PS, Royal H, Weinreb JC, et al. Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance. J Nucl Med 2005;46:1225–39.PubMed
18.
Zurück zum Zitat Kuehl H, Antoch G. How much CT do we need for PET/CT? Nuklearmedizin 2005;44:24–31. Kuehl H, Antoch G. How much CT do we need for PET/CT? Nuklearmedizin 2005;44:24–31.
19.
Zurück zum Zitat Paterson A, Frush DP, Donnelly LF. Helical CT of the body: are settings adjusted for pediatric patients? Am J Roentgenol 2001;176:297–301. Paterson A, Frush DP, Donnelly LF. Helical CT of the body: are settings adjusted for pediatric patients? Am J Roentgenol 2001;176:297–301.
20.
Zurück zum Zitat Piepsz A, Hahn K, Roca I, Ciofetta G, Toth G, Gordon I, et al. A radiopharmaceutical schedule for image in pediatric. Recommendations of the Pediatric Task Group of the European Association of Nuclear Medicine. Eur J Nucl Med 1990;17:127–9.PubMedCrossRef Piepsz A, Hahn K, Roca I, Ciofetta G, Toth G, Gordon I, et al. A radiopharmaceutical schedule for image in pediatric. Recommendations of the Pediatric Task Group of the European Association of Nuclear Medicine. Eur J Nucl Med 1990;17:127–9.PubMedCrossRef
21.
Zurück zum Zitat Hahn K, Fischer S. Radiation dose and radiation protection from paediatric nuclear medicine procedures. Der Nuklearmediziner 2002;25:90–100.CrossRef Hahn K, Fischer S. Radiation dose and radiation protection from paediatric nuclear medicine procedures. Der Nuklearmediziner 2002;25:90–100.CrossRef
22.
Zurück zum Zitat Bundesamt für Strahlenschutz. Bekanntmachung der diagnostischen Referenzwerte für radiologische und nuklearmedizinische Untersuchungen. BAnz;Nr. 143 vom 05.08.2003. Bundesamt für Strahlenschutz. Bekanntmachung der diagnostischen Referenzwerte für radiologische und nuklearmedizinische Untersuchungen. BAnz;Nr. 143 vom 05.08.2003.
23.
Zurück zum Zitat Noßke D, Minkow V, Brix G. Establishment and application of diagnostic reference levels for nuclear medicine procedure in Germany. Nuklearmedizin 2004;43:79–84.PubMed Noßke D, Minkow V, Brix G. Establishment and application of diagnostic reference levels for nuclear medicine procedure in Germany. Nuklearmedizin 2004;43:79–84.PubMed
24.
Zurück zum Zitat Frush DP, Donnelly LF, Rosen NS. Computed tomography and radiation risk: what pediatric health care providers should know. Pediatrics 2003;112:951–7.PubMedCrossRef Frush DP, Donnelly LF, Rosen NS. Computed tomography and radiation risk: what pediatric health care providers should know. Pediatrics 2003;112:951–7.PubMedCrossRef
25.
Zurück zum Zitat Pages J, Buls N, Osteau M. CT doses in children: a multicentre study. Br J Radiol 2003;76:803–11.PubMedCrossRef Pages J, Buls N, Osteau M. CT doses in children: a multicentre study. Br J Radiol 2003;76:803–11.PubMedCrossRef
26.
Zurück zum Zitat Wildberger JE, Mahnken AH, Schmitz-Rode T, Flohr T, Stargardt A, Haage P, et al. Individually adapted examination protocols for reduction of radiation exposure in chest CT. Invest Radiol 2001;10:604–11.CrossRef Wildberger JE, Mahnken AH, Schmitz-Rode T, Flohr T, Stargardt A, Haage P, et al. Individually adapted examination protocols for reduction of radiation exposure in chest CT. Invest Radiol 2001;10:604–11.CrossRef
27.
Zurück zum Zitat Yekeler E. Pediatric abdominal applications of multidetector-row CT. Eur J Radiol 2004;52:31–43.PubMedCrossRef Yekeler E. Pediatric abdominal applications of multidetector-row CT. Eur J Radiol 2004;52:31–43.PubMedCrossRef
28.
Zurück zum Zitat Wormanns D, Diederich S, Lenzen H, Lange P, Link TM, Ludwig K, et al. Abdominal spiral CT in children: which radiation exposure is required? Eur Radiol 2001;11:2262–6.PubMedCrossRef Wormanns D, Diederich S, Lenzen H, Lange P, Link TM, Ludwig K, et al. Abdominal spiral CT in children: which radiation exposure is required? Eur Radiol 2001;11:2262–6.PubMedCrossRef
29.
Zurück zum Zitat Nickoloff EL, Dutta AK, Lu ZF. Influence of phantom diameter, kVp and scan mode upon computed tomography dose index. Med Phys 2003;30:395–402.PubMedCrossRef Nickoloff EL, Dutta AK, Lu ZF. Influence of phantom diameter, kVp and scan mode upon computed tomography dose index. Med Phys 2003;30:395–402.PubMedCrossRef
30.
Zurück zum Zitat Kalender WA, Wolf H, Suess C. Dose reduction in CT by anatomically adapted tube current modulation. II. Phantom measurements. Med Phys 1999;26:2248–53.PubMedCrossRef Kalender WA, Wolf H, Suess C. Dose reduction in CT by anatomically adapted tube current modulation. II. Phantom measurements. Med Phys 1999;26:2248–53.PubMedCrossRef
31.
Zurück zum Zitat Rogalla P, Stöver B, Scheer I, Juran R, Gaedicke G, Hamm B. Low-dose spiral CT: application to paediatric chest imaging. Pediatr Radiol 1999;29:565–9.PubMedCrossRef Rogalla P, Stöver B, Scheer I, Juran R, Gaedicke G, Hamm B. Low-dose spiral CT: application to paediatric chest imaging. Pediatr Radiol 1999;29:565–9.PubMedCrossRef
32.
Zurück zum Zitat Weingaertner U, Lorenzen M, Nagel HD, Weber C, Adam G. Diagnostic imaging in polytrauma: comparison of radiation exposure from whole-body MSCT and conventional radiography with organ-specific CT. Fortschr Röntgenstr 2004;176:1039–44.CrossRef Weingaertner U, Lorenzen M, Nagel HD, Weber C, Adam G. Diagnostic imaging in polytrauma: comparison of radiation exposure from whole-body MSCT and conventional radiography with organ-specific CT. Fortschr Röntgenstr 2004;176:1039–44.CrossRef
33.
Zurück zum Zitat Chan FP, Rubin GD. MDCT angiography of pediatric vascular disease of the abdomen, pelvis, and extremities. Pediatr Radiol 2005;35:40–53.PubMedCrossRef Chan FP, Rubin GD. MDCT angiography of pediatric vascular disease of the abdomen, pelvis, and extremities. Pediatr Radiol 2005;35:40–53.PubMedCrossRef
34.
Zurück zum Zitat Wu TH, Huang YH, Lee JJS, Wang SY, Wang SC, Su CT, et al. Radiation exposure during transmission measurements: comparison between CT- and germanium-based techniques with a current PET scanner. Eur J Nucl Med Mol Imaging 2004;31:38–43.PubMedCrossRef Wu TH, Huang YH, Lee JJS, Wang SY, Wang SC, Su CT, et al. Radiation exposure during transmission measurements: comparison between CT- and germanium-based techniques with a current PET scanner. Eur J Nucl Med Mol Imaging 2004;31:38–43.PubMedCrossRef
35.
Zurück zum Zitat Wu TH, Chu TC, Huang YH, Chen LK, Mok SP, Lee JK, et al. A positron emission tomography/computed tomography (PET/CT) acquisition protocol for CT radiation dose optimization. Nucl Med Commun 2005;26:323–30.PubMedCrossRef Wu TH, Chu TC, Huang YH, Chen LK, Mok SP, Lee JK, et al. A positron emission tomography/computed tomography (PET/CT) acquisition protocol for CT radiation dose optimization. Nucl Med Commun 2005;26:323–30.PubMedCrossRef
36.
Zurück zum Zitat Brianzoni E, Rossi G, Ancidei S, Berbellini A, Capocetti F, Cidda C, et al. Radiotherapy planning: PET/CT scanner performances in the definition of gross tumour volume and clincal target volume. Eur J Nucl Med Mol Imaging 2005;32:1392–9.PubMedCrossRef Brianzoni E, Rossi G, Ancidei S, Berbellini A, Capocetti F, Cidda C, et al. Radiotherapy planning: PET/CT scanner performances in the definition of gross tumour volume and clincal target volume. Eur J Nucl Med Mol Imaging 2005;32:1392–9.PubMedCrossRef
37.
Zurück zum Zitat Weckesser M, Konemann S, Brinkmann M, Willich N, Schober O. PET/CT in radiotherapy. Radiologe 2004;44:1096–104.PubMedCrossRef Weckesser M, Konemann S, Brinkmann M, Willich N, Schober O. PET/CT in radiotherapy. Radiologe 2004;44:1096–104.PubMedCrossRef
38.
Zurück zum Zitat Slomka PJ, Dey D, Przetak C, Aladl UE, Baum RP. Automated 3-dimensional registration of stand-alone F-18-FDG whole body PET with CT. J Nucl Med 2003;44:1156–67.PubMed Slomka PJ, Dey D, Przetak C, Aladl UE, Baum RP. Automated 3-dimensional registration of stand-alone F-18-FDG whole body PET with CT. J Nucl Med 2003;44:1156–67.PubMed
39.
Zurück zum Zitat Nakamoto Y, Cohade C, Tatsumi M, Hammoud D, Wahl RL. CT appearance of bone meastases detected with FDG PET as part of the same PET/CT examination. Radiology 2005;237:627–34.PubMedCrossRef Nakamoto Y, Cohade C, Tatsumi M, Hammoud D, Wahl RL. CT appearance of bone meastases detected with FDG PET as part of the same PET/CT examination. Radiology 2005;237:627–34.PubMedCrossRef
40.
Zurück zum Zitat Franzius C, Daldrup-Link HE, Sciuk J, Rummeny EJ, Bielack S, Jürgens H, et al. FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: comparison with spiral CT. Ann Oncol 2001;12:479–86.PubMedCrossRef Franzius C, Daldrup-Link HE, Sciuk J, Rummeny EJ, Bielack S, Jürgens H, et al. FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: comparison with spiral CT. Ann Oncol 2001;12:479–86.PubMedCrossRef
41.
Zurück zum Zitat Kaste SC, Howard SC, McCarville EB, Krasin MJ, Kogos PG, Hudson MM. 18F-FDG-avid sites mimicking active disease in pediatric Hodgkin’s. Pediatr Radiol 2004;35:141–54.PubMedCrossRef Kaste SC, Howard SC, McCarville EB, Krasin MJ, Kogos PG, Hudson MM. 18F-FDG-avid sites mimicking active disease in pediatric Hodgkin’s. Pediatr Radiol 2004;35:141–54.PubMedCrossRef
42.
Zurück zum Zitat Franzius C, Lang K, Vormoor J, Weckesser M, Schober O. Whole body PET-CT with C-11-meta-hydroxyephedrine (C-11-HED) in tumors of the sympathetic nervous system: comparison with I-123-mIBG SPECT. Eur J Nucl Med Mol Imaging 2005;32 Suppl 1:54. Franzius C, Lang K, Vormoor J, Weckesser M, Schober O. Whole body PET-CT with C-11-meta-hydroxyephedrine (C-11-HED) in tumors of the sympathetic nervous system: comparison with I-123-mIBG SPECT. Eur J Nucl Med Mol Imaging 2005;32 Suppl 1:54.
43.
Zurück zum Zitat Serafini G, Ongaro L, Mori A, Rossi C, Cavalloro F, Tagliaferri C, et al. Anesthesia for MRI in the pediatric patient. Minerva Anestesiol 2005;71:361–6.PubMed Serafini G, Ongaro L, Mori A, Rossi C, Cavalloro F, Tagliaferri C, et al. Anesthesia for MRI in the pediatric patient. Minerva Anestesiol 2005;71:361–6.PubMed
44.
Zurück zum Zitat Coté CJ, Karl HW, Notterman DA. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics 2000;106:633–44.PubMedCrossRef Coté CJ, Karl HW, Notterman DA. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics 2000;106:633–44.PubMedCrossRef
45.
Zurück zum Zitat Franzius C, Sciuk J, Brinkschmidt C, Jürgens H, Schober O. Evaluation of chemotherapy response in primary bone tumors with F-18-FDG-PET compared with histologically assessed tumor necrosis. Clin Nucl Med 2000;25:874–81.PubMedCrossRef Franzius C, Sciuk J, Brinkschmidt C, Jürgens H, Schober O. Evaluation of chemotherapy response in primary bone tumors with F-18-FDG-PET compared with histologically assessed tumor necrosis. Clin Nucl Med 2000;25:874–81.PubMedCrossRef
46.
Zurück zum Zitat Franzius C, Daldrup-Link HE, Wagner-Bohn A, Sciuk J, Heindel WL, Jürgens H, et al. FDG PET for detection of recurrences from malignant primary bone tumors: comparison with conventional imaging. Ann Oncol 2002;13:157–60.PubMedCrossRef Franzius C, Daldrup-Link HE, Wagner-Bohn A, Sciuk J, Heindel WL, Jürgens H, et al. FDG PET for detection of recurrences from malignant primary bone tumors: comparison with conventional imaging. Ann Oncol 2002;13:157–60.PubMedCrossRef
47.
Zurück zum Zitat Lucas JD, O’Doherty MJ, Wong JCH, Bingham JB, McKee PH, Fletcher CDM, et al. Evaluation of fluorodeoxyglucose positron emission tomography in the management of soft-tissue sarcoma. J Bone Joint Surg (Br) 1998;80-B:441–7.CrossRef Lucas JD, O’Doherty MJ, Wong JCH, Bingham JB, McKee PH, Fletcher CDM, et al. Evaluation of fluorodeoxyglucose positron emission tomography in the management of soft-tissue sarcoma. J Bone Joint Surg (Br) 1998;80-B:441–7.CrossRef
48.
Zurück zum Zitat Lucas JD, O’Doherty MJ, Cronin BF, Marsden PK, Lodge MA, McKee PH, et al. Prospective evaluation of soft tissue masses and sarcomas using fluorodeoxyglucose positron emission tomography. Br J Surg 1999;86:550–6.PubMedCrossRef Lucas JD, O’Doherty MJ, Cronin BF, Marsden PK, Lodge MA, McKee PH, et al. Prospective evaluation of soft tissue masses and sarcomas using fluorodeoxyglucose positron emission tomography. Br J Surg 1999;86:550–6.PubMedCrossRef
49.
Zurück zum Zitat Hawkins DS, Rajendran JG, Conrad EU, Bruckner JD, Eary JF. Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography. Cancer 2002;94:3277–84.PubMedCrossRef Hawkins DS, Rajendran JG, Conrad EU, Bruckner JD, Eary JF. Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography. Cancer 2002;94:3277–84.PubMedCrossRef
50.
Zurück zum Zitat Montravers F, McNamara D, Landman-Parker J, Grahek D, Kerrou K, Younsi N, et al. [F-18]FDG in childhood lymphoma: clinical utility and impact on management. Eur J Nucl Med Mol Imaging 2002;29:1155–65.PubMedCrossRef Montravers F, McNamara D, Landman-Parker J, Grahek D, Kerrou K, Younsi N, et al. [F-18]FDG in childhood lymphoma: clinical utility and impact on management. Eur J Nucl Med Mol Imaging 2002;29:1155–65.PubMedCrossRef
51.
Zurück zum Zitat Hudson MM, Krasin MJ, Kaste SC. PET imaging in pediatric Hodgkin’s lymphoma. Pediatr Radiol 2004;34:190–8.PubMedCrossRef Hudson MM, Krasin MJ, Kaste SC. PET imaging in pediatric Hodgkin’s lymphoma. Pediatr Radiol 2004;34:190–8.PubMedCrossRef
52.
Zurück zum Zitat Tatsumi M, Cohade C, Nakamato Y, Fishman EK, Wahl RL. Direct comparison of FDG PET and CT findings in patients with lymphoma: initial experience. Radiology 2005;237:1038–45.PubMedCrossRef Tatsumi M, Cohade C, Nakamato Y, Fishman EK, Wahl RL. Direct comparison of FDG PET and CT findings in patients with lymphoma: initial experience. Radiology 2005;237:1038–45.PubMedCrossRef
53.
Zurück zum Zitat Krasin MJ, Hudson MM, Kaste SC. Positron emission tomography in pediatric radiation oncology: integration in the treatment-planning process. Pediatr Radiol 2004;34:214–21.PubMedCrossRef Krasin MJ, Hudson MM, Kaste SC. Positron emission tomography in pediatric radiation oncology: integration in the treatment-planning process. Pediatr Radiol 2004;34:214–21.PubMedCrossRef
Metadaten
Titel
Is PET/CT necessary in paediatric oncology?
verfasst von
Christiane Franzius
Kai Uwe Juergens
Otmar Schober
Publikationsdatum
01.08.2006
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 8/2006
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-006-0114-6

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