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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.07.2008 | Original Article

Quantification of dopaminergic neurotransmission SPECT studies with ¹²³I-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation

verfasst von: Cristina Crespo, Judith Gallego, Albert Cot, Carles Falcón, Santiago Bullich, Deborah Pareto, Pablo Aguiar, Josep Sempau, Francisco Lomeña, Francisco Calviño, Javier Pavía, Domènec Ros

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 7/2008

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Abstract

Purpose

¹²³I-labelled radioligands are commonly used for single-photon emission computed tomography (SPECT) imaging of the dopaminergic system to study the dopamine transporter binding. The aim of this work was to compare the quantitative capabilities of two different SPECT systems through Monte Carlo (MC) simulation.

Methods

The SimSET MC code was employed to generate simulated projections of a numerical phantom for two gamma cameras equipped with a parallel and a fan-beam collimator, respectively. A fully 3D iterative reconstruction algorithm was used to compensate for attenuation, the spatially variant point spread function (PSF) and scatter. A post-reconstruction partial volume effect (PVE) compensation was also developed.

Results

For both systems, the correction for all degradations and PVE compensation resulted in recovery factors of the theoretical specific uptake ratio (SUR) close to 100%. For a SUR value of 4, the recovered SUR for the parallel imaging system was 33% for a reconstruction without corrections (OSEM), 45% for a reconstruction with attenuation correction (OSEM-A), 56% for a 3D reconstruction with attenuation and PSF corrections (OSEM-AP), 68% for OSEM-AP with scatter correction (OSEM-APS) and 97% for OSEM-APS plus PVE compensation (OSEM-APSV). For the fan-beam imaging system, the recovered SUR was 41% without corrections, 55% for OSEM-A, 65% for OSEM-AP, 75% for OSEM-APS and 102% for OSEM-APSV.

Conclusion

Our findings indicate that the correction for degradations increases the quantification accuracy, with PVE compensation playing a major role in the SUR quantification. The proposed methodology allows us to reach similar SUR values for different SPECT systems, thereby allowing a reliable standardisation in multicentric studies.

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Titel: Quantification of dopaminergic neurotransmission SPECT studies with 123I-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation
verfasst von: Cristina Crespo
Judith Gallego
Albert Cot
Carles Falcón
Santiago Bullich
Deborah Pareto
Pablo Aguiar
Josep Sempau
Francisco Lomeña
Francisco Calviño
Javier Pavía
Domènec Ros
Publikationsdatum: 01.07.2008
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 7/2008
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-007-0711-z

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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