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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.01.2016 | Original Article

Assessment of metastatic colorectal cancer with hybrid imaging: comparison of reading performance using different combinations of anatomical and functional imaging techniques in PET/MRI and PET/CT in a short case series

verfasst von: C. Brendle, N. F. Schwenzer, H. Rempp, H. Schmidt, C. Pfannenberg, C. la Fougère, K. Nikolaou, C. Schraml

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2016

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Abstract

Purpose

The purpose was to investigate the diagnostic performance of different combinations of anatomical and functional imaging techniques in PET/MRI and PET/CT for the evaluation of metastatic colorectal cancer lesions.

Methods

Image data of 15 colorectal cancer patients (FDG-PET/CT and subsequent FDG-PET/MRI) were retrospectively evaluated by two readers in five reading sessions: MRI (morphology) alone, MRI/diffusion-weighted MRI (DWI), MRI/PET, MRI/DWI/PET; and PET/CT. Diagnostic performance of lesion detection with each combination was assessed in general and organ-based. The reference standard was given by histology and/or follow-up imaging. Separate analysis of mucinous tumours was performed.

Results

One hundred and eighty lesions (110 malignant) were evaluated (intestine n = 6, liver n = 37, lymph nodes n = 55, lung n = 4, and peritoneal n = 74). The overall lesion-based diagnostic accuracy was 0.46 for MRI, 0.47 for MRI/DWI, 0.57 for MRI/PET, 0.69 for MRI/DWI/PET and 0.66 for PET/CT. In the organ-based assessment, MRI/DWI/PET showed the highest accuracy for liver metastases (0.74), a comparable accuracy to PET/CT in peritoneal lesions (0.55), and in lymph node metastases (0.84). The accuracy in mucinous tumour lesions was limited in all modalities (MRI/DWI/PET = 0.52).

Conclusions

PET/MRI including DWI is comparable to PET/CT in the evaluation of colorectal cancer metastases, with a markedly higher accuracy when using combined imaging data than the modalities separately. Further improvement is needed in the imaging of peritoneal carcinomatosis and mucinous tumours.

Chen LB, Tong JL, Song HZ, Zhu H, Wang YC. (18)F-DG PET/CT in detection of recurrence and metastasis of colorectal cancer. World J Gastroenterol : WJG. 2007;13(37):5025–9.PubMedCentralCrossRefPubMed

Beets-Tan RG, Lambregts DM, Maas M, Bipat S, Barbaro B, Caseiro-Alves F, et al. Magnetic resonance imaging for the clinical management of rectal cancer patients: recommendations from the 2012 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol. 2013;23(9):2522–31. doi:10.1007/s00330-013-2864-4.CrossRefPubMed

van der Paardt MP, Zagers MB, Beets-Tan RG, Stoker J, Bipat S. Patients who undergo preoperative chemoradiotherapy for locally advanced rectal cancer restaged by using diagnostic MR imaging: a systematic review and meta-analysis. Radiology. 2013;269(1):101–12. doi:10.1148/radiol.13122833.CrossRefPubMed

Lambregts DM, Maas M, Cappendijk VC, Prompers LM, Mottaghy FM, Beets GL, et al. Whole-body diffusion-weighted magnetic resonance imaging: current evidence in oncology and potential role in colorectal cancer staging. Eur J Cancer. 2011;47(14):2107–16. doi:10.1016/j.ejca.2011.05.013.CrossRefPubMed

Schmidt G. Importance of whole body MRI for staging of colorectal cancer. Radiologe. 2012;52(6):537–44. doi:10.1007/s00117-011-2285-9.CrossRefPubMed

Squillaci E, Manenti G, Mancino S, Ciccio C, Calabria F, Danieli R, et al. Staging of colon cancer: whole-body MRI vs. whole-body PET-CT--initial clinical experience. Abdom Imaging. 2008;33(6):676–88. doi:10.1007/s00261-007-9347-5.CrossRefPubMed

Kim DJ, Kim JH, Ryu YH, Jeon TJ, Yu JS, Chung JJ. Nodal staging of rectal cancer: high-resolution pelvic MRI versus (1)(8)F-FDGPET/CT. J Comput Assist Tomogr. 2011;35(5):531–4. doi:10.1097/RCT.0b013e318225720f.CrossRefPubMed

Cho YB, Chun HK, Kim MJ, Choi JY, Park CM, Kim BT, et al. Accuracy of MRI and 18F-FDG PET/CT for restaging after preoperative concurrent chemoradiotherapy for rectal cancer. World J Surg. 2009;33(12):2688–94. doi:10.1007/s00268-009-0248-3.CrossRefPubMed

Lambregts DM, Maas M, Riedl RG, Bakers FC, Verwoerd JL, Kessels AG, et al. Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer-a per lesion validation study. Eur Radiol. 2011;21(2):265–73. doi:10.1007/s00330-010-1937-x.PubMedCentralCrossRefPubMed

10.

Maas M, Rutten IJ, Nelemans PJ, Lambregts DM, Cappendijk VC, Beets GL, et al. What is the most accurate whole-body imaging modality for assessment of local and distant recurrent disease in colorectal cancer? A meta-analysis : imaging for recurrent colorectal cancer. Eur J Nucl Med Mol Imaging. 2011;38(8):1560–71. doi:10.1007/s00259-011-1785-1.PubMedCentralCrossRefPubMed

11.

Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology. 2010;257(3):674–84. doi:10.1148/radiol.10100729.CrossRefPubMed

12.

Bonanni L, De’liguori Carino N, Deshpande R, Ammori BJ, Sherlock DJ, Valle JW, et al. A comparison of diagnostic imaging modalities for colorectal liver metastases. Eur J Surg Oncol : J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2014;40(5):545–50. doi:10.1016/j.ejso.2013.12.023.CrossRef

13.

Floriani I, Torri V, Rulli E, Garavaglia D, Compagnoni A, Salvolini L, et al. Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging : JMRI. 2010;31(1):19–31. doi:10.1002/jmri.22010.CrossRefPubMed

14.

Eiber M, Fingerle AA, Brugel M, Gaa J, Rummeny EJ, Holzapfel K. Detection and classification of focal liver lesions in patients with colorectal cancer: retrospective comparison of diffusion-weighted MR imaging and multi-slice CT. Eur J Radiol. 2012;81(4):683–91. doi:10.1016/j.ejrad.2011.01.072.CrossRefPubMed

15.

Chang MC, Chen JH, Liang JA, Huang WS, Cheng KY, Kao CH. PET or PET/CT for detection of peritoneal carcinomatosis: a meta-analysis. Clin Nucl Med. 2013;38(8):623–9. doi:10.1097/RLU.0b013e318299609f.CrossRefPubMed

16.

Klumpp BD, Schwenzer N, Aschoff P, Miller S, Kramer U, Claussen CD, et al. Preoperative assessment of peritoneal carcinomatosis: intraindividual comparison of 18F-FDG PET/CT and MRI. Abdom Imaging. 2013;38(1):64–71. doi:10.1007/s00261-012-9881-7.CrossRefPubMed

17.

Satoh Y, Ichikawa T, Motosugi U, Kimura K, Sou H, Sano K, et al. Diagnosis of peritoneal dissemination: comparison of 18F-FDG PET/CT, diffusion-weighted MRI, and contrast-enhanced MDCT. AJR Am J Roentgenol. 2011;196(2):447–53. doi:10.2214/AJR.10.4687.CrossRefPubMed

18.

Soussan M, Des Guetz G, Barrau V, Aflalo-Hazan V, Pop G, Mehanna Z, et al. Comparison of FDG-PET/CT and MR with diffusion-weighted imaging for assessing peritoneal carcinomatosis from gastrointestinal malignancy. Eur Radiol. 2012;22(7):1479–87. doi:10.1007/s00330-012-2397-2.CrossRefPubMed

19.

Schwenzer NF, Schmidt H, Gatidis S, Brendle C, Muller M, Konigsrainer I, et al. Measurement of apparent diffusion coefficient with simultaneous MR/positron emission tomography in patients with peritoneal carcinomatosis: comparison with 18F-FDG-PET. J Magn Reson Imaging : JMRI. 2014;40(5):1121–8. doi:10.1002/jmri.24497.CrossRefPubMed

20.

Grassetto G, Capirci C, Marzola MC, Rampin L, Chondrogiannis S, Musto A, et al. Colorectal cancer: prognostic role of 18F-FDG-PET/CT. Abdom Imaging. 2012;37(4):575–9. doi:10.1007/s00261-011-9789-7.CrossRefPubMed

21.

Heusch P, Nensa F, Schaarschmidt B, Sivanesapillai R, Beiderwellen K, Gomez B, et al. Diagnostic accuracy of whole-body PET/MRI and whole-body PET/CT for TNM staging in oncology. Eur J Nucl Med Mol Imaging. 2014. doi:10.1007/s00259-014-2885-5.

22.

Bailey DL, Barthel H, Beuthin-Baumann B, Beyer T, Bisdas S, Boellaard R, et al. Combined PET/MR: where are we now? Summary report of the second international workshop on PET/MR imaging April 8–12, 2013, Tubingen, Germany. Mol Imaging Biol : MIB : Off Publ Acad Mol Imaging. 2014;16(3):295–310. doi:10.1007/s11307-014-0725-4.

23.

Schwenzer NF, Schraml C, Muller M, Brendle C, Sauter A, Spengler W, et al. Pulmonary lesion assessment: comparison of whole-body hybrid MR/PET and PET/CT imaging--pilot study. Radiology. 2012;264(2):551–8. doi:10.1148/radiol.12111942.CrossRefPubMed

24.

Shrout PE. Measurement reliability and agreement in psychiatry. Stat Methods Med Res. 1998;7(3):301–17.CrossRefPubMed

25.

Schmidt GP, Baur-Melnyk A, Haug A, Utzschneider S, Becker CR, Tiling R, et al. Whole-body MRI at 1.5 T and 3 T compared with FDG-PET-CT for the detection of tumour recurrence in patients with colorectal cancer. Eur Radiol. 2009;19(6):1366–78. doi:10.1007/s00330-008-1289-y.CrossRefPubMed

26.

Kitajima K, Murakami K, Yamasaki E, Domeki Y, Tsubaki M, Sunagawa M, et al. Performance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: Comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CT. Eur J Nucl Med Mol Imaging. 2009;36(9):1388–96. doi:10.1007/s00259-009-1081-5.CrossRefPubMed

27.

Deleau C, Buecher B, Rousseau C, Kraeber-Bodere F, Flamant M, des Varannes SB, et al. Clinical impact of fluorodeoxyglucose-positron emission tomography scan/computed tomography in comparison with computed tomography on the detection of colorectal cancer recurrence. Eur J Gastroenterol Hepatol. 2011;23(3):275–81. doi:10.1097/MEG.0b013e328343eaa0.CrossRefPubMed

28.

Rojas Llimpe FL, Di Fabio F, Ercolani G, Giampalma E, Cappelli A, Serra C, et al. Imaging in resectable colorectal liver metastasis patients with or without preoperative chemotherapy: results of the PROMETEO-01 study. Br J Cancer. 2014;111(4):667–73. doi:10.1038/bjc.2014.351.PubMedCentralCrossRefPubMed

29.

Kwak JY, Kim JS, Kim HJ, Ha HK, Yu CS, Kim JC. Diagnostic value of FDG-PET/CT for lymph node metastasis of colorectal cancer. World J Surg. 2012;36(8):1898–905. doi:10.1007/s00268-012-1575-3.CrossRefPubMed

30.

Lu YY, Chen JH, Ding HJ, Chien CR, Lin WY, Kao CH. A systematic review and meta-analysis of pretherapeutic lymph node staging of colorectal cancer by 18F-FDG PET or PET/CT. Nucl Med Commun. 2012;33(11):1127–33. doi:10.1097/MNM.0b013e328357b2d9.CrossRefPubMed

31.

Mizukami Y, Ueda S, Mizumoto A, Sasada T, Okumura R, Kohno S, et al. Diffusion-weighted magnetic resonance imaging for detecting lymph node metastasis of rectal cancer. World J Surg. 2011;35(4):895–9. doi:10.1007/s00268-011-0986-x.CrossRefPubMed

32.

Au-Yeung AW, Luk WH, Lo AX. Imaging features of colorectal liver metastasis in FDG PET-CT: a retrospective correlative analysis between CT attenuation and FDG uptake. Nucl Med Commun. 2012;33(4):403–7. doi:10.1097/MNM.0b013e32834f4d54.CrossRefPubMed

33.

Nasu K, Kuroki Y, Minami M. Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma. Jpn J Radiol. 2012;30(2):120–7. doi:10.1007/s11604-011-0023-x.CrossRefPubMed

34.

Berger KL, Nicholson SA, Dehdashti F, Siegel BA. FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features. AJR Am J Roentgenol. 2000;174(4):1005–8. doi:10.2214/ajr.174.4.1741005.CrossRefPubMed

35.

Yang ZY, Hu SL, Shi W, Zhu BL, Xu JY, Zhang YJ. The clinical value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in postoperative patients with gastrointestinal mucinous adenocarcinoma. Nucl Med Commun. 2011;32(11):1018–25. doi:10.1097/MNM.0b013e32834bbd22.CrossRefPubMed

Titel: Assessment of metastatic colorectal cancer with hybrid imaging: comparison of reading performance using different combinations of anatomical and functional imaging techniques in PET/MRI and PET/CT in a short case series
verfasst von: C. Brendle
N. F. Schwenzer
H. Rempp
H. Schmidt
C. Pfannenberg
C. la Fougère
K. Nikolaou
C. Schraml
Publikationsdatum: 01.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2016
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3137-z

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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