Skip to main content
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 5/2017

23.11.2016 | Original Article

Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction

verfasst von: Stijn Bonte, Pieter Vandemaele, Stijn Verleden, Kurt Audenaert, Karel Deblaere, Ingeborg Goethals, Roel Van Holen

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 5/2017

Einloggen, um Zugang zu erhalten

Excerpt

With the advent of positron emission tomography (PET) the brain metabolism can be mapped through detection of a glucose analogue radiotracer. This has proven to be a great tool in the expansion of our knowledge on brain function. However, the way in which the brain grows old is still not entirely unravelled by the scientific community. A thorough understanding of ageing is of great importance in the discrimination of the normal from the pathological brain. …
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Chételat G, Landeau B, Salmon E, et al. Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity. Neuroimage 2013;76:167–77.CrossRefPubMed Chételat G, Landeau B, Salmon E, et al. Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity. Neuroimage 2013;76:167–77.CrossRefPubMed
2.
Zurück zum Zitat Zuendorf G, Kerrouche N, Herholz K, Baron J-C. Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging. Human Brain Mapping 2003;18(1):13–21.CrossRefPubMed Zuendorf G, Kerrouche N, Herholz K, Baron J-C. Efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging. Human Brain Mapping 2003;18(1):13–21.CrossRefPubMed
3.
Zurück zum Zitat Moeller JR, Ishikawa T, Dhawan V, et al. The metabolic topography of normal aging. Journal of Cerebral Blood Flow and Metabolism 1996;16(3):385–98.CrossRefPubMed Moeller JR, Ishikawa T, Dhawan V, et al. The metabolic topography of normal aging. Journal of Cerebral Blood Flow and Metabolism 1996;16(3):385–98.CrossRefPubMed
4.
Zurück zum Zitat Petit-Taboué MC, Landeau B, Desson JF, et al. Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping. Neuroimage 1998;7(3):176–84.CrossRefPubMed Petit-Taboué MC, Landeau B, Desson JF, et al. Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping. Neuroimage 1998;7(3):176–84.CrossRefPubMed
5.
Zurück zum Zitat Hsieh T-C, Lin W-Y, Ding H-J, et al. Sex-and Age-Related Differences in Brain FDG Metabolism of Healthy Adults: An SPM Analysis. Journal of Neuroimaging 2012;22(1):21–7.CrossRefPubMed Hsieh T-C, Lin W-Y, Ding H-J, et al. Sex-and Age-Related Differences in Brain FDG Metabolism of Healthy Adults: An SPM Analysis. Journal of Neuroimaging 2012;22(1):21–7.CrossRefPubMed
6.
Zurück zum Zitat Willis M W, Ketter T A, Kimbrell T A, et al. Age sex and laterality effects on cerebral glucose metabolism in healthy adults. Psychiatry Research: Neuroimaging 2002;114(1):23–37.CrossRefPubMed Willis M W, Ketter T A, Kimbrell T A, et al. Age sex and laterality effects on cerebral glucose metabolism in healthy adults. Psychiatry Research: Neuroimaging 2002;114(1):23–37.CrossRefPubMed
7.
Zurück zum Zitat Fujimoto T, Matsumoto T, Fujita S, et al. Changes in glucose metabolism due to aging and gender-related differences in the healthy human brain. Psychiatry Research: Neuroimaging 2008;164(1):58–72.CrossRefPubMed Fujimoto T, Matsumoto T, Fujita S, et al. Changes in glucose metabolism due to aging and gender-related differences in the healthy human brain. Psychiatry Research: Neuroimaging 2008;164(1):58–72.CrossRefPubMed
8.
Zurück zum Zitat Yoshizawa H, Gazes Y, Stern Y, et al. Characterizing the normative profile of 18F-FDG PET brain imaging: Sex difference aging effect and cognitive reserve. Psychiatry Research: Neuroimaging 2014;221(1):78–85.CrossRefPubMed Yoshizawa H, Gazes Y, Stern Y, et al. Characterizing the normative profile of 18F-FDG PET brain imaging: Sex difference aging effect and cognitive reserve. Psychiatry Research: Neuroimaging 2014;221(1):78–85.CrossRefPubMed
9.
Zurück zum Zitat Loessner A, Alavi A, Lewandrowski KU, et al. Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age. Journal of Nuclear Medicine 1995;36(7):1141–9.PubMed Loessner A, Alavi A, Lewandrowski KU, et al. Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age. Journal of Nuclear Medicine 1995;36(7):1141–9.PubMed
10.
Zurück zum Zitat Shen X, Liu H, Hu Z, et al. The relationship between cerebral glucose metabolism and age: report of a large brain PET data set. PloS One 2012;7(12):e51517.CrossRefPubMedPubMedCentral Shen X, Liu H, Hu Z, et al. The relationship between cerebral glucose metabolism and age: report of a large brain PET data set. PloS One 2012;7(12):e51517.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Iseki E, Murayama N, Yamamoto R, et al. Construction of a 18F-FDG PET normative database of Japanese healthy elderly subjects and its application to demented and mild cognitive impairment patients. International Journal of Geriatric Psychiatry 2010;25(4):352–61.CrossRefPubMed Iseki E, Murayama N, Yamamoto R, et al. Construction of a 18F-FDG PET normative database of Japanese healthy elderly subjects and its application to demented and mild cognitive impairment patients. International Journal of Geriatric Psychiatry 2010;25(4):352–61.CrossRefPubMed
12.
Zurück zum Zitat Kim I-J, Kim S-J, Kim Y-K. Age-and sex-associated changes in cerebral glucose metabolism in normal healthy subjects: statistical parametric mapping analysis of F-18 fluorodeoxyglucose brain positron emission tomography. Acta Radiologica 2009;50(10):1169–74.CrossRefPubMed Kim I-J, Kim S-J, Kim Y-K. Age-and sex-associated changes in cerebral glucose metabolism in normal healthy subjects: statistical parametric mapping analysis of F-18 fluorodeoxyglucose brain positron emission tomography. Acta Radiologica 2009;50(10):1169–74.CrossRefPubMed
13.
Zurück zum Zitat Kochunov P, Mangin J-F, Coyle T, et al. Age-related morphology trends of cortical sulci. Human Brain Mapping 2005;26(3):210–20.CrossRefPubMed Kochunov P, Mangin J-F, Coyle T, et al. Age-related morphology trends of cortical sulci. Human Brain Mapping 2005;26(3):210–20.CrossRefPubMed
14.
Zurück zum Zitat Murphy D GM, DeCarli C, Schapiro M B, et al. Age-related differences in volumes of subcortical nuclei brain matter and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Archives of Neurology 1992;49(8):839–45.CrossRefPubMed Murphy D GM, DeCarli C, Schapiro M B, et al. Age-related differences in volumes of subcortical nuclei brain matter and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Archives of Neurology 1992;49(8):839–45.CrossRefPubMed
15.
Zurück zum Zitat Ge Y, Grossman R I, Babb J S, Rabin M L, Mannon L J, et al. Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis. American Journal of Neuroradiology 2002;23(8):1327–33.PubMed Ge Y, Grossman R I, Babb J S, Rabin M L, Mannon L J, et al. Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis. American Journal of Neuroradiology 2002;23(8):1327–33.PubMed
16.
Zurück zum Zitat Soret M, Bacharach S L, Buvat I. Partial-volume effect in PET tumor imaging. Journal of Nuclear Medicine 2007;48(6):932– 45.CrossRefPubMed Soret M, Bacharach S L, Buvat I. Partial-volume effect in PET tumor imaging. Journal of Nuclear Medicine 2007;48(6):932– 45.CrossRefPubMed
17.
Zurück zum Zitat Matsuda H, Ohnishi T, Asada T, et al. Correction for partial-volume effects on brain perfusion SPECT in healthy men. Journal of Nuclear Medicine 2003;44(8):1243–52.PubMed Matsuda H, Ohnishi T, Asada T, et al. Correction for partial-volume effects on brain perfusion SPECT in healthy men. Journal of Nuclear Medicine 2003;44(8):1243–52.PubMed
18.
Zurück zum Zitat Meltzer C C, Leal J P, Mayberg H S, et al. Correction of PET data for partial volume effects in human cerebral cortex by MR imaging. Journal of Computer Assisted Tomography 1990;14(4):561–70.CrossRefPubMed Meltzer C C, Leal J P, Mayberg H S, et al. Correction of PET data for partial volume effects in human cerebral cortex by MR imaging. Journal of Computer Assisted Tomography 1990;14(4):561–70.CrossRefPubMed
19.
Zurück zum Zitat Müller-Gärtner H W, Links J M, Prince J L, et al. Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. Journal of Cerebral Blood Flow and Metabolism 1992;12(4):571–83.CrossRefPubMed Müller-Gärtner H W, Links J M, Prince J L, et al. Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. Journal of Cerebral Blood Flow and Metabolism 1992;12(4):571–83.CrossRefPubMed
20.
Zurück zum Zitat Quarantelli M, Berkouk K, Prinster A, et al. Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction. Journal of Nuclear Medicine 2004;45(2):192–201.PubMed Quarantelli M, Berkouk K, Prinster A, et al. Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction. Journal of Nuclear Medicine 2004;45(2):192–201.PubMed
21.
Zurück zum Zitat Park H-J, Lee J D, Chun J W, et al. Cortical surface-based analysis of 18F-FDG PET: measured metabolic abnormalities in schizophrenia are affected by cortical structural abnormalities. Neuroimage 2006;31(4): 1434–44.CrossRefPubMed Park H-J, Lee J D, Chun J W, et al. Cortical surface-based analysis of 18F-FDG PET: measured metabolic abnormalities in schizophrenia are affected by cortical structural abnormalities. Neuroimage 2006;31(4): 1434–44.CrossRefPubMed
22.
Zurück zum Zitat Curiati PK, Tamashiro-Duran JH, Duran FLS, et al. Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [18F] Fluorodeoxyglucose–Positron-Emission Tomography Study with Partial Volume Effects Correction. American Journal of Neuroradiology 2011;32(3):560–5.CrossRefPubMed Curiati PK, Tamashiro-Duran JH, Duran FLS, et al. Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [18F] Fluorodeoxyglucose–Positron-Emission Tomography Study with Partial Volume Effects Correction. American Journal of Neuroradiology 2011;32(3):560–5.CrossRefPubMed
23.
Zurück zum Zitat Ibáñez V, Pietrini P, Furey M L, et al. Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging after correction for brain atrophy. Brain Research Bulletin 2004;63(2):147–54.CrossRefPubMed Ibáñez V, Pietrini P, Furey M L, et al. Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging after correction for brain atrophy. Brain Research Bulletin 2004;63(2):147–54.CrossRefPubMed
24.
Zurück zum Zitat Kochunov P, Ramage AE, Lancaster JL, et al. Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging. Neuroimage 2009;45(1):17–28.CrossRefPubMed Kochunov P, Ramage AE, Lancaster JL, et al. Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging. Neuroimage 2009;45(1):17–28.CrossRefPubMed
25.
Zurück zum Zitat Kalpouzos G, Chételat G, Baron J-C, et al. Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiology of Aging 2009;30(1):112–24.CrossRefPubMed Kalpouzos G, Chételat G, Baron J-C, et al. Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiology of Aging 2009;30(1):112–24.CrossRefPubMed
26.
Zurück zum Zitat De Leon MJ, Convit A, Wolf OT, et al. Prediction of cognitive decline in normal elderly subjects with 2-[18F] fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET). Proceedings of the National Academy of Sciences 2001;98(19):10966–71.CrossRef De Leon MJ, Convit A, Wolf OT, et al. Prediction of cognitive decline in normal elderly subjects with 2-[18F] fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET). Proceedings of the National Academy of Sciences 2001;98(19):10966–71.CrossRef
27.
Zurück zum Zitat Yanase D, Matsunari I, Yajima K, et al. Brain FDG PET study of normal aging in Japanese: effect of atrophy correction. European Journal of Nuclear Medicine and Molecular Imaging 2005;32(7):794–805.CrossRefPubMed Yanase D, Matsunari I, Yajima K, et al. Brain FDG PET study of normal aging in Japanese: effect of atrophy correction. European Journal of Nuclear Medicine and Molecular Imaging 2005;32(7):794–805.CrossRefPubMed
28.
Zurück zum Zitat Knopman D S, Jack C R, Wiste H J, et al. 18 F-fluorodeoxyglucose positron emission tomography aging and apolipoprotein E genotype in cognitively normal persons. Neurobiology of Aging 2014;35(9):2096–106.CrossRefPubMedPubMedCentral Knopman D S, Jack C R, Wiste H J, et al. 18 F-fluorodeoxyglucose positron emission tomography aging and apolipoprotein E genotype in cognitively normal persons. Neurobiology of Aging 2014;35(9):2096–106.CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Nugent S, Tremblay S, Chen K W, et al. Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiology of Aging 2014;35(6):1386–95.CrossRefPubMed Nugent S, Tremblay S, Chen K W, et al. Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiology of Aging 2014;35(6):1386–95.CrossRefPubMed
30.
Zurück zum Zitat Nugent S, Castellano C-A, Goffaux P, et al. Glucose hypometabolism is highly localized but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. American Journal of Physiology-Endocrinology and Metabolism 2014:ajpendo–00067. Nugent S, Castellano C-A, Goffaux P, et al. Glucose hypometabolism is highly localized but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. American Journal of Physiology-Endocrinology and Metabolism 2014:ajpendo–00067.
31.
Zurück zum Zitat Rousset O G, Ma Y, Evans A C. Correction for partial volume effects in PET: principle and validation. Journal of Nuclear Medicine 1998;39(5):904–11.PubMed Rousset O G, Ma Y, Evans A C. Correction for partial volume effects in PET: principle and validation. Journal of Nuclear Medicine 1998;39(5):904–11.PubMed
32.
Zurück zum Zitat Thomas B A. 2012. Improved brain PET quantification using partial volume correction techniques. UCL (University College London). Thomas B A. 2012. Improved brain PET quantification using partial volume correction techniques. UCL (University College London).
33.
Zurück zum Zitat Folstein M F, Folstein S E, McHugh P R. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 1975;12(3):189–98.CrossRefPubMed Folstein M F, Folstein S E, McHugh P R. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 1975;12(3):189–98.CrossRefPubMed
34.
Zurück zum Zitat Andreasen N C, O’Leary D S, Cizadlo T, Arndt S, Rezai K, Watkins G L, et al. Remembering the past: two facets of episodic memory explored with positron emission tomography. American Journal of Psychiatry 1995;152(11):1576–85.CrossRefPubMed Andreasen N C, O’Leary D S, Cizadlo T, Arndt S, Rezai K, Watkins G L, et al. Remembering the past: two facets of episodic memory explored with positron emission tomography. American Journal of Psychiatry 1995;152(11):1576–85.CrossRefPubMed
35.
Zurück zum Zitat Daube-Witherspoon ME, Matej S, Karp JS, Lewitt RM. Application of the row action maximum likelihood algorithm with spherical basis functions to clinical PET imaging. IEEE Transactions on Nuclear Science 2001;48(1): 24–30.CrossRef Daube-Witherspoon ME, Matej S, Karp JS, Lewitt RM. Application of the row action maximum likelihood algorithm with spherical basis functions to clinical PET imaging. IEEE Transactions on Nuclear Science 2001;48(1): 24–30.CrossRef
36.
Zurück zum Zitat Watson C C, Newport DMEC, Casey M E. 1996. Three-dimensional image reconstruction in radiology and nuclear medicine. Springer. Watson C C, Newport DMEC, Casey M E. 1996. Three-dimensional image reconstruction in radiology and nuclear medicine. Springer.
37.
Zurück zum Zitat Hammers A, Allom R, Koepp M J, et al. Three-dimensional maximum probability atlas of the human brain with particular reference to the temporal lobe. Human brain mapping 2003;19(4):224–47.CrossRefPubMed Hammers A, Allom R, Koepp M J, et al. Three-dimensional maximum probability atlas of the human brain with particular reference to the temporal lobe. Human brain mapping 2003;19(4):224–47.CrossRefPubMed
38.
Zurück zum Zitat Zaidi H, Ruest T, Schoenahl F, Montandon M-L. Comparative assessment of statistical brain MR image segmentation algorithms and their impact on partial volume correction in PET. Neuroimage 2006;32(4):1591–607.CrossRefPubMed Zaidi H, Ruest T, Schoenahl F, Montandon M-L. Comparative assessment of statistical brain MR image segmentation algorithms and their impact on partial volume correction in PET. Neuroimage 2006;32(4):1591–607.CrossRefPubMed
39.
Zurück zum Zitat Hoetjes N J, van Velden F HP, Hoekstra O S, Hoekstra C J, Krak N C, Lammertsma A A, et al. Partial volume correction strategies for quantitative FDG PET in oncology. European journal of nuclear medicine and molecular imaging 2010;37(9):1679–87.CrossRefPubMedPubMedCentral Hoetjes N J, van Velden F HP, Hoekstra O S, Hoekstra C J, Krak N C, Lammertsma A A, et al. Partial volume correction strategies for quantitative FDG PET in oncology. European journal of nuclear medicine and molecular imaging 2010;37(9):1679–87.CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Gutierrez D, Montandon M-L, Assal F, Allaoua M, Ratib O, Lövblad K-O, et al. Anatomically guided voxel-based partial volume effect correction in brain PET: impact of MRI segmentation. Computerized Medical Imaging and Graphics 2012;36(8):610–9.CrossRefPubMed Gutierrez D, Montandon M-L, Assal F, Allaoua M, Ratib O, Lövblad K-O, et al. Anatomically guided voxel-based partial volume effect correction in brain PET: impact of MRI segmentation. Computerized Medical Imaging and Graphics 2012;36(8):610–9.CrossRefPubMed
41.
Zurück zum Zitat Teo B-K, Seo Y, Bacharach S L, et al. Partial-volume correction in PET: validation of an iterative postreconstruction method with phantom and patient data. Journal of Nuclear Medicine 2007;48(5):802–10.PubMed Teo B-K, Seo Y, Bacharach S L, et al. Partial-volume correction in PET: validation of an iterative postreconstruction method with phantom and patient data. Journal of Nuclear Medicine 2007;48(5):802–10.PubMed
42.
Zurück zum Zitat Borghammer P, Cumming P, Aanerud J, Gjedde A. Artefactual subcortical hyperperfusion in PET studies normalized to global mean: lessons from Parkinson’s disease. Neuroimage 2009;45(2):249–57.CrossRefPubMed Borghammer P, Cumming P, Aanerud J, Gjedde A. Artefactual subcortical hyperperfusion in PET studies normalized to global mean: lessons from Parkinson’s disease. Neuroimage 2009;45(2):249–57.CrossRefPubMed
43.
Zurück zum Zitat Dukart J, Mueller K, Horstmann A, Vogt B, Frisch S, Barthel H, et al. Differential effects of global and cerebellar normalization on detection and differentiation of dementia in FDG-PET studies. Neuroimage 2010;49 (2):1490–5.CrossRefPubMed Dukart J, Mueller K, Horstmann A, Vogt B, Frisch S, Barthel H, et al. Differential effects of global and cerebellar normalization on detection and differentiation of dementia in FDG-PET studies. Neuroimage 2010;49 (2):1490–5.CrossRefPubMed
44.
Zurück zum Zitat Kushner M, Tobin M, Alavi A, Chawluk J, Rosen M, Fazekas F, et al. Cerebellar glucose consumption in normal and pathologic states using fluorine-FDG and PET. Journal of Nuclear Medicine 1987;28(11): 1667–70.PubMed Kushner M, Tobin M, Alavi A, Chawluk J, Rosen M, Fazekas F, et al. Cerebellar glucose consumption in normal and pathologic states using fluorine-FDG and PET. Journal of Nuclear Medicine 1987;28(11): 1667–70.PubMed
45.
Zurück zum Zitat Yakushev I, Landvogt C, Buchholz H-G, Fellgiebel A, Hammers A, Scheurich A, et al. Choice of reference area in studies of Alzheimer’s disease using positron emission tomography with fluorodeoxyglucose-F18. Psychiatry Research: Neuroimaging 2008;164(2):143–53.CrossRefPubMed Yakushev I, Landvogt C, Buchholz H-G, Fellgiebel A, Hammers A, Scheurich A, et al. Choice of reference area in studies of Alzheimer’s disease using positron emission tomography with fluorodeoxyglucose-F18. Psychiatry Research: Neuroimaging 2008;164(2):143–53.CrossRefPubMed
Metadaten
Titel
Healthy brain ageing assessed with 18F-FDG PET and age-dependent recovery factors after partial volume effect correction
verfasst von
Stijn Bonte
Pieter Vandemaele
Stijn Verleden
Kurt Audenaert
Karel Deblaere
Ingeborg Goethals
Roel Van Holen
Publikationsdatum
23.11.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 5/2017
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-016-3569-0

Weitere Artikel der Ausgabe 5/2017

European Journal of Nuclear Medicine and Molecular Imaging 5/2017 Zur Ausgabe