Introduction
Material and methods
Study population and design
18F-DPA-714 PET/CT
Flow cytometry of HSPCs and monocytes
Statistical analysis
Results
Study population
Baseline characteristics | ACS patients; acute phase (n = 20) | Healthy controls (n = 19) | P-value acute phase vs healthy controls | Patients; 3 months post-ACS (n = 16) | P-value acute phase vs 3 months post-ACS | P-value 3 months post-ACS vs healthy controls |
---|---|---|---|---|---|---|
Age, years | 63 ± 8 | 62 ± 9 | 0.503 | n/a | n/a | n/a |
Sex, men/women | 16/4 | 12/7 | 0.412 | n/a | n/a | n/a |
BMI, kg/m2 | 28.5 ± 5 | 25 ± 3 | 0.026 | 28.7 ± 5 | 0.351 | 0.014 |
Systolic blood pressure, mmHg | 135 ± 18 | 127 ± 16 | 0.189 | n/a | n/a | n/a |
Diastolic blood pressure, mmHg | 79 ± 13 | 80 ± 11 | 0.696 | n/a | n/a | n/a |
Smoking, yes/past/no | 6/7/7 | 1/7/11 | 0.137 | n/a | n/a | n/a |
Hypertension, yes/no | 9/11 | 0/19 | 0.001 | n/a | n/a | n/a |
CRP, mg/dl | 13.2[5.2–18] | 0.8[0.4–1.2] | <0.001 | 1.7[0.4–3.7] | 0.001 | 0.042 |
Total cholesterol, mmol/L | 5.1 ± 0.7 | 5.6 ± 1.0 | 0.087 | 3.9 ± 0.7 | <0.001 | <0.001 |
HDL cholesterol, mmol/L | 1.3 ± 0.5 | 1.7 ± 0.4 | 0.014 | 1.4 ± 0.5 | 0.667 | 0.030 |
LDL cholesterol, mmol/L | 3.2 ± 0.8 | 3.5 ± 0.8 | 0.295 | 2.0 ± 0.5 | <0.001 | <0.001 |
Triglycerides, mmol/L | 1.2[0.8–1.7] | 0.8[0.5–1.3] | 0.065 | 1.1[0.8–1.3] | 0.887 | 0.059 |
Leukocytes, *10^9/L | 9.7 ± 2.6 | 4.9 ± 0.8 | <0.001 | 7.3 ± 1.9 | 0.012 | <0.001 |
Neutrophils, *10^9/L | 6.0 ± 3.1 | 2.7 ± 0.6 | <0.001 | 4.2 ± 1.1 | 0.061 | <0.001 |
Lymphocytes, *10^9/L | 2.3 ± 0.6 | 1.55 ± 0.5 | <0.001 | 2.1 ± 0.9 | 0.603 | 0.021 |
Monocytes, *10^9/L | 0.9 ± 0.3 | 0.4 ± 0.1 | <0.001 | 0.7 ± 0.3 | 0.035 | <0.001 |