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Cancer Immunology, Immunotherapy

Erschienen in:

01.09.2003 | Review

NK cells in allogeneic bone marrow transplantation

verfasst von: Ioannis A. Voutsadakis

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 9/2003

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Abstract

NK cells, until recently an ignored subset of lymphocytes, have begun to emerge as important cytotoxic effectors. It is now accepted that NK cells together with T cells constitute major actors in graft-versus-leukemia reaction after allogeneic bone marrow transplantation (BMT). Over the last several years the mechanisms regulating the activation of NK cells have been the subject of intense investigations encouraged by the clinical implications that these studies will have. This article provides a general overview of NK-cells biology and regulation pertinent to their function in allogeneic BMT, followed by a review of the in vivo preclinical and clinical evidence for the beneficial effect of NK cells in the adoptive immunotherapy of leukemia.

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Titel: NK cells in allogeneic bone marrow transplantation
verfasst von: Ioannis A. Voutsadakis
Publikationsdatum: 01.09.2003
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 9/2003
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-003-0378-7

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