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International Orthopaedics
Erschienen in: International Orthopaedics 1/2012

01.01.2012 | Review Article

Clinical outcome after microfracture of the knee: a meta-analysis of before/after-data of controlled studies

verfasst von: Lukas Negrin, Florian Kutscha-Lissberg, Gerald Gartlehner, Vilmos Vecsei

Erschienen in: International Orthopaedics | Ausgabe 1/2012

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Abstract

Purpose

The aims of this study were to systematically review the medical literature, in order to find controlled studies about microfracture in the treatment of patients with full-thickness cartilage lesions of the knee, to statistically combine these studies in order to determine a best estimate of the average treatment effect, and to gather information to detect cartilage-specific and patient-specific factors that might have an influence on the clinical outcome.

Methods

We searched four electronic databases for controlled clinical trials or controlled prospective observational studies. We pooled before/after-data of study arms using the term microfracture.

Results

We calculated an overall best estimate of 1.106, with [0.566; 1.646] as 95% confidence interval of the mean standardized treatment effect for a representative patient population.

Conclusions

Our meta-analysis revealed a clinically relevant improvement of the postoperative clinical status as compared to the preoperative status. An increase of 22 overall KOOS points may provide a rough estimate for the mean expected treatment effect achieved by microfracturing.
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Metadaten
Titel
Clinical outcome after microfracture of the knee: a meta-analysis of before/after-data of controlled studies
verfasst von
Lukas Negrin
Florian Kutscha-Lissberg
Gerald Gartlehner
Vilmos Vecsei
Publikationsdatum
01.01.2012
Verlag
Springer-Verlag
Erschienen in
International Orthopaedics / Ausgabe 1/2012
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-011-1364-x

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