Erschienen in:
01.06.2004 | Case Report
Rapid improvement of disseminated aspergillosis with caspofungin/voriconazole combination in an adult leukemic patient
verfasst von:
G. Damaj, V. Ivanov, B. Le Brigand, E. D’incan, M. F. Doglio, K. Bilger, C. Faucher, N. Vey, J. A. Gastaut
Erschienen in:
Annals of Hematology
|
Ausgabe 6/2004
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Abstract
A 57-year-old man with acute myeloid leukemia (AML) French-American-British (FAB) 4 developed disseminated invasive cerebral and pulmonary aspergillosis during postinduction aplasia. According to international consensus, infection was categorized as probable (two host factors: deep neutropenia for >10 days and refractory fever for >96 h; major clinical criteria of lower respiratory tract and CNS invasive fungal infection; positive results for galactomannan antigen in three blood samples). After the failure of standard amphotericin-based therapy, the spectacular regression of multifocal brain and lung lesions was rapidly achieved under a caspofungin acetate/voriconazole combination. Further permanent caspofungin maintenance with voriconazole added during aplasia periods permitted two consolidation courses and autograft-based intensification without any delay.