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Erschienen in: Annals of Hematology 4/2005

01.04.2005 | Review Article

Recent developments in the management of invasive fungal infections in patients with hematological malignancies

verfasst von: Meinolf Karthaus, Oliver A. Cornely

Erschienen in: Annals of Hematology | Ausgabe 4/2005

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Abstract

Despite recent advances in the last decade, invasive fungal infections are still associated with a high morbidity and mortality. Invasive fungal infections constitute severe infectious complications in patients with hematological malignancies receiving myelosuppressive chemotherapy or sustained immunosuppression after allogeneic transplant regimens. Following a long period of stagnation, considerable progress has been made during the last 5 years in non-culture-based diagnostics and in the treatment of invasive fungal infections. This review highlights recent developments in the epidemiology, diagnosis, and treatment in the context of state-of-the-art management of invasive fungal infections in cancer patients.
Literatur
1.
Zurück zum Zitat Almyroudis N, Jaffe D, Sepkowitz KA, Pamer EG, Meier EN, Papadopoulos E, Small TN, Papanicolaou GA (2003) Risk factors for late invasive aspergillosis (IA) after allogeneic stem cell transplantation. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 457, M-1006 Almyroudis N, Jaffe D, Sepkowitz KA, Pamer EG, Meier EN, Papadopoulos E, Small TN, Papanicolaou GA (2003) Risk factors for late invasive aspergillosis (IA) after allogeneic stem cell transplantation. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 457, M-1006
2.
Zurück zum Zitat Ascioglu S, Rex JH, de Pauw B et al (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34:7–14CrossRefPubMed Ascioglu S, Rex JH, de Pauw B et al (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34:7–14CrossRefPubMed
3.
Zurück zum Zitat Bischoff TR, Tallent S, Adera T, Wenzel RP, Edmond MB (2003) Epidemiology of nosocomial candidemia: a six-year national perspective. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 348, K 452e Bischoff TR, Tallent S, Adera T, Wenzel RP, Edmond MB (2003) Epidemiology of nosocomial candidemia: a six-year national perspective. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 348, K 452e
4.
Zurück zum Zitat Boogaerts M, Winston DJ, Bow EJ, Garber G, Reboli AC, Schwarer AP, Novitzky N, Boehme A, Chwetzoff E, De Beule K (2001) Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy. A randomized, controlled trial. Ann Intern Med 135:412–422 Boogaerts M, Winston DJ, Bow EJ, Garber G, Reboli AC, Schwarer AP, Novitzky N, Boehme A, Chwetzoff E, De Beule K (2001) Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy. A randomized, controlled trial. Ann Intern Med 135:412–422
5.
Zurück zum Zitat Bow EJ, Laverdière M, Lussier N, Rotstein C, Cheang MS, Ioannou S (2002) Antifungal prophylaxis for severely neutropenic chemotherapy recipients. A meta-analysis of randomized-controlled clinical trials. Cancer 94:3230–3246 Bow EJ, Laverdière M, Lussier N, Rotstein C, Cheang MS, Ioannou S (2002) Antifungal prophylaxis for severely neutropenic chemotherapy recipients. A meta-analysis of randomized-controlled clinical trials. Cancer 94:3230–3246
6.
Zurück zum Zitat Buchheidt D, Hummel M, Schleiermacher D, Spiess B, Skladny H, Schwerdtfeger R, Cornely OA, Wilhelm S, Reuter S, Kern WV, Suedhoff T, Moerz H, Hehlmann R, German Aspergillus PCR Study Group. Prospective multicenter clinical evaluation of a nested PCR assay, a lightcycler mediated PCR assay and a galactomannan ELISA for detection of invasive aspergillosis in neutropenic high risk patients. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 478, M-2057 Buchheidt D, Hummel M, Schleiermacher D, Spiess B, Skladny H, Schwerdtfeger R, Cornely OA, Wilhelm S, Reuter S, Kern WV, Suedhoff T, Moerz H, Hehlmann R, German Aspergillus PCR Study Group. Prospective multicenter clinical evaluation of a nested PCR assay, a lightcycler mediated PCR assay and a galactomannan ELISA for detection of invasive aspergillosis in neutropenic high risk patients. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 478, M-2057
7.
Zurück zum Zitat Buechner T, Fegeler W, Berhardt H et al (2002) Treatment of severe candida infections in high-risk patients: an interdisciplinary consensus. Eur J Clin Microbiol Infect Dis 21:337–352 Buechner T, Fegeler W, Berhardt H et al (2002) Treatment of severe candida infections in high-risk patients: an interdisciplinary consensus. Eur J Clin Microbiol Infect Dis 21:337–352
8.
Zurück zum Zitat Cornely OA, Ullmann AJ, Karthaus M (2003) Evidence-based assessment of primary antifungal prophylaxis in patients with hematologic malignancies. Blood 101:3365–3372 Cornely OA, Ullmann AJ, Karthaus M (2003) Evidence-based assessment of primary antifungal prophylaxis in patients with hematologic malignancies. Blood 101:3365–3372
9.
Zurück zum Zitat Cornely OA, Bethe U, Böhme A Buchheidt D, Cesaro S, Karthaus M, Maertens J et al (2003) Detection of predictor variables for breakthrough invasive fungal infection (IFI) during secondary prophylaxis (SP). Results from a European registry. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 456, M-1001 Cornely OA, Bethe U, Böhme A Buchheidt D, Cesaro S, Karthaus M, Maertens J et al (2003) Detection of predictor variables for breakthrough invasive fungal infection (IFI) during secondary prophylaxis (SP). Results from a European registry. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 456, M-1001
10.
Zurück zum Zitat Denning DW, Ribaud P, Milpied N et al (2002) Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis. Clin Infect Dis 34:563–571CrossRefPubMed Denning DW, Ribaud P, Milpied N et al (2002) Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis. Clin Infect Dis 34:563–571CrossRefPubMed
11.
Zurück zum Zitat Edwards JE Jr, Bodey GP, Bowden RA et al (1997) International conference for the development of a consensus on the management and prevention of severe candidal infections [see comments]. Clin Infect Dis 25:43–59 Edwards JE Jr, Bodey GP, Bowden RA et al (1997) International conference for the development of a consensus on the management and prevention of severe candidal infections [see comments]. Clin Infect Dis 25:43–59
12.
Zurück zum Zitat Eser B, Yildiz O, Altuntas F, Alp E, Sari I, Ozkan M, Ekici E, Koc N, Cetin M, Ilhan O, Unal A (2003) Microbiologically documented bacterial and fungal infections following peripheral blood stem cell transplantation for hematological malignancies (abstract 5514). In: Proceedings 45th ASH 2003 Eser B, Yildiz O, Altuntas F, Alp E, Sari I, Ozkan M, Ekici E, Koc N, Cetin M, Ilhan O, Unal A (2003) Microbiologically documented bacterial and fungal infections following peripheral blood stem cell transplantation for hematological malignancies (abstract 5514). In: Proceedings 45th ASH 2003
13.
Zurück zum Zitat Greenberg RN, Anstead G, Herbrecht R, Langston A, Marr K, Mullane K, Raad I, Schiller G, Schuster M, Van Burik J, Wingard JR, Hare R, Corcoran G (2003) Posaconazole (POS) experience in the treatment of zygomycosis. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 476, M-1757 Greenberg RN, Anstead G, Herbrecht R, Langston A, Marr K, Mullane K, Raad I, Schiller G, Schuster M, Van Burik J, Wingard JR, Hare R, Corcoran G (2003) Posaconazole (POS) experience in the treatment of zygomycosis. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 476, M-1757
14.
Zurück zum Zitat Harousseau JL, Locatelli F, Perez A, Ramirez PD, Michallet M (2003) Amphotericin B lipid complex (ABLC) for prophylaxis of fungal infections in patients given either unrelated or mismatched related donor (abstract 3624). In: Proceedings 45th ASH 2003 Harousseau JL, Locatelli F, Perez A, Ramirez PD, Michallet M (2003) Amphotericin B lipid complex (ABLC) for prophylaxis of fungal infections in patients given either unrelated or mismatched related donor (abstract 3624). In: Proceedings 45th ASH 2003
15.
Zurück zum Zitat Hebart H, Löffler J, Reitze H, Engel A, Schumacher U, Klingebiel T et al (2000) Prospective screening by a panfungal polymerase chain reaction assay in patients at risk for fungal infections. Implications for the management of febrile neutropenia. Br J Haematol 111:635–640 Hebart H, Löffler J, Reitze H, Engel A, Schumacher U, Klingebiel T et al (2000) Prospective screening by a panfungal polymerase chain reaction assay in patients at risk for fungal infections. Implications for the management of febrile neutropenia. Br J Haematol 111:635–640
16.
Zurück zum Zitat Hebart H, Loeffler J, Kanz L, Einsele H (2000) Molecular methods in the diagnosis of infections in the immunocompromised host. Curr Opin Infect Dis 13:355–359 Hebart H, Loeffler J, Kanz L, Einsele H (2000) Molecular methods in the diagnosis of infections in the immunocompromised host. Curr Opin Infect Dis 13:355–359
17.
Zurück zum Zitat Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, de Pauw B (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408–415CrossRefPubMed Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, de Pauw B (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408–415CrossRefPubMed
18.
Zurück zum Zitat Herbrecht R (2003) Early diagnosis: CT, antigen, or PCR (abstract 1328)? In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 524 Herbrecht R (2003) Early diagnosis: CT, antigen, or PCR (abstract 1328)? In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 524
19.
Zurück zum Zitat Hughes WT, Armstrong D, Bodey GP et al (2002) 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730–751CrossRefPubMed Hughes WT, Armstrong D, Bodey GP et al (2002) 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730–751CrossRefPubMed
20.
Zurück zum Zitat Jarvis WR (1995) Epidemiology of nosocomial infections, with emphasis on Candida species. Clin Infect Dis 20:1526–1530PubMed Jarvis WR (1995) Epidemiology of nosocomial infections, with emphasis on Candida species. Clin Infect Dis 20:1526–1530PubMed
21.
Zurück zum Zitat Karthaus M, Ullmann AJ, Cornely OA (2004) Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. Ann Intern Med 140:579–580 Karthaus M, Ullmann AJ, Cornely OA (2004) Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. Ann Intern Med 140:579–580
22.
Zurück zum Zitat Kullberg BJ, Pappas P, Ruhnke M, Viscoli C, Cleary JD, Church LWP, Brown JM, Rex JH, Hilton F, Oborska I, Hodges M, Schlamm H, Sobel J (2004) Voriconazole compared with a strategy of amphotericin B followed by fluconazole for treatment of candidaemia in non-neutropenic patients(abstract). ECCMID 2004:0245 Kullberg BJ, Pappas P, Ruhnke M, Viscoli C, Cleary JD, Church LWP, Brown JM, Rex JH, Hilton F, Oborska I, Hodges M, Schlamm H, Sobel J (2004) Voriconazole compared with a strategy of amphotericin B followed by fluconazole for treatment of candidaemia in non-neutropenic patients(abstract). ECCMID 2004:0245
23.
Zurück zum Zitat Maertens J, Raad I, Petrikkos G, Selleslag D, Petersen FB, Sable CA, Kartsonis N, Ngai A, Taylor A, Patterson TF, Denning D, Walsh TJ (2002) Update of the multicenter, noncomparative study of caspofungin in adults with invasive aspergillosis refractory or intolerant to other antifungal agents: an analysis of 90 patients. In: 42nd Interscience conference on antimicrobial agents and chemotherapy Maertens J, Raad I, Petrikkos G, Selleslag D, Petersen FB, Sable CA, Kartsonis N, Ngai A, Taylor A, Patterson TF, Denning D, Walsh TJ (2002) Update of the multicenter, noncomparative study of caspofungin in adults with invasive aspergillosis refractory or intolerant to other antifungal agents: an analysis of 90 patients. In: 42nd Interscience conference on antimicrobial agents and chemotherapy
24.
Zurück zum Zitat Maertens JA, Theunissen K, Verbeken E, Katrien L, Verhaegen J, Boogaerts M, Van Eldere J (2004) Prospective clinical evaluation of lower cut-offs for galactomannan detection in adult neutropenic cancer patients and hematological stem cell recipients. Br J Haematol 126:852-860 Maertens JA, Theunissen K, Verbeken E, Katrien L, Verhaegen J, Boogaerts M, Van Eldere J (2004) Prospective clinical evaluation of lower cut-offs for galactomannan detection in adult neutropenic cancer patients and hematological stem cell recipients. Br J Haematol 126:852-860
25.
Zurück zum Zitat Maertens J, Raad I, Sable CA, Ngai A, Berman R, Patterson TF, Denning D, Walsh T. Multicenter (2000) Noncomparative study to evaluate safety and efficacy of caspofungin (CAS) in adults with invasive aspergillosis (IA) refractory (R) or intolerant (I) to amphotericin B (AMB), AMB lipid formulations (lipid AMB), or azoles. In: 40th ICAAC, Toronto, 2000, Abstract 1103:371 Maertens J, Raad I, Sable CA, Ngai A, Berman R, Patterson TF, Denning D, Walsh T. Multicenter (2000) Noncomparative study to evaluate safety and efficacy of caspofungin (CAS) in adults with invasive aspergillosis (IA) refractory (R) or intolerant (I) to amphotericin B (AMB), AMB lipid formulations (lipid AMB), or azoles. In: 40th ICAAC, Toronto, 2000, Abstract 1103:371
26.
Zurück zum Zitat Marr KA, Carter RA, Boeckh M, Martin P, Corey L (2002) Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 100:4358–4366 Marr KA, Carter RA, Boeckh M, Martin P, Corey L (2002) Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 100:4358–4366
27.
Zurück zum Zitat Marr K, Hachem R, Papanicolaou G, Somani J, Arduino JM, Lipka J, Ngai A, Chodakewitz J, Sable C (introduction by Michael Boeckh). Retrospective study of concomitant use of caspofungin with cyclosporin A (CsA) in patients treated during marketed use (abstract 3613). In: Proceedings 45th ASH 2003 Marr K, Hachem R, Papanicolaou G, Somani J, Arduino JM, Lipka J, Ngai A, Chodakewitz J, Sable C (introduction by Michael Boeckh). Retrospective study of concomitant use of caspofungin with cyclosporin A (CsA) in patients treated during marketed use (abstract 3613). In: Proceedings 45th ASH 2003
28.
Zurück zum Zitat Marr KA, Crippa F, Leisenring W, Hoyle M, Boeckh M, Balajee SA, Nichols WG, Musher B, Corey L (2004) Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. Blood 103:1527–1533 Marr KA, Crippa F, Leisenring W, Hoyle M, Boeckh M, Balajee SA, Nichols WG, Musher B, Corey L (2004) Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. Blood 103:1527–1533
29.
Zurück zum Zitat Marr KA, Leisenring W, Crippa F, Slattery JT, Corey L, Boeckh M, McDonald GB (2004) Cyclophosphamide metabolism is affected by azole antifungals. Blood 103:1557–1559 Marr KA, Leisenring W, Crippa F, Slattery JT, Corey L, Boeckh M, McDonald GB (2004) Cyclophosphamide metabolism is affected by azole antifungals. Blood 103:1557–1559
30.
Zurück zum Zitat Marty FM, Cosimi LA, Baden LR (2004) Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. N Engl J Med 350:950–952CrossRef Marty FM, Cosimi LA, Baden LR (2004) Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. N Engl J Med 350:950–952CrossRef
31.
Zurück zum Zitat Mattei D, Mordini N, Lo Nigro C, Musso M, Gallamini A (2003) Galactomannan antigenemia for early diagnosis and treatment of invasive aspergillosis: three years single centre experience (abstract 3632). In: Proceedings 45th ASH 2003 Mattei D, Mordini N, Lo Nigro C, Musso M, Gallamini A (2003) Galactomannan antigenemia for early diagnosis and treatment of invasive aspergillosis: three years single centre experience (abstract 3632). In: Proceedings 45th ASH 2003
32.
Zurück zum Zitat Mattiuzzi GN, Kantarjian H, Alvarado G, Kontoyiannis D, Pierce S, Cortes J, Giles F, Raad I, Verstovsek S, Leitz G, Estey E (2003) Intravenous itraconazole (ITRA) vs caspofungin (CASPO) prophylaxis (P) in patients (PTS) with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) undergoing induction chemotherapy (IC). In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 451, M-984 Mattiuzzi GN, Kantarjian H, Alvarado G, Kontoyiannis D, Pierce S, Cortes J, Giles F, Raad I, Verstovsek S, Leitz G, Estey E (2003) Intravenous itraconazole (ITRA) vs caspofungin (CASPO) prophylaxis (P) in patients (PTS) with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) undergoing induction chemotherapy (IC). In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 451, M-984
33.
Zurück zum Zitat Mora-Duarte J, Betts R, Rotstein C, Lopes-Colombo A, Thomson-Moya L, Smietana J et al (2002) Caspofungin (CAS) versus Amphotericin B deoxycholate (AmB) in the treatment (Rx) of invasive candidiasis (IC) in neutropenic (N) and non-neutropenic (NN) patients (Pts): a multicentre, randomized, double-blind study. N Engl J Med 347:2020–2029CrossRefPubMed Mora-Duarte J, Betts R, Rotstein C, Lopes-Colombo A, Thomson-Moya L, Smietana J et al (2002) Caspofungin (CAS) versus Amphotericin B deoxycholate (AmB) in the treatment (Rx) of invasive candidiasis (IC) in neutropenic (N) and non-neutropenic (NN) patients (Pts): a multicentre, randomized, double-blind study. N Engl J Med 347:2020–2029CrossRefPubMed
34.
Zurück zum Zitat Morrissey C.O., Halliday C., Chen S., Slavin M., Wesselingh S., Sorrell T. Comparison of the Sensitivity and Specificity of Aspergillus galactomannan (GM) sandwich ELISA and a nested Aspergillus PCR assay for the diagnosis of invasive aspergillosis (IA). In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 460, M-1019 Morrissey C.O., Halliday C., Chen S., Slavin M., Wesselingh S., Sorrell T. Comparison of the Sensitivity and Specificity of Aspergillus galactomannan (GM) sandwich ELISA and a nested Aspergillus PCR assay for the diagnosis of invasive aspergillosis (IA). In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 460, M-1019
35.
Zurück zum Zitat Nucci M, Marr KA, Queiroz-Telles F, Martins CA, Trabasso P, Costa S, Voltarelli JC, Colombo AL, Imhof A, Pasquini R, Maiolino A, Souza CA, Anaissie E (2004) Fusarium infection in hematopoietic stem cell transplant recipients. Clin Infect Dis 38:1237–1242 Nucci M, Marr KA, Queiroz-Telles F, Martins CA, Trabasso P, Costa S, Voltarelli JC, Colombo AL, Imhof A, Pasquini R, Maiolino A, Souza CA, Anaissie E (2004) Fusarium infection in hematopoietic stem cell transplant recipients. Clin Infect Dis 38:1237–1242
36.
Zurück zum Zitat Pappas PG, Morgan J, Hajjeh RA, Transplant Associated Infection Surveillance Network (TRANSNET) (2003) Prospective surveillance for invasive fungal infections (IFIs) in hematopoietic stem cell (HSCTs) and solid organ transplant recipients (SOTs) in the United States. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 458, M-1010 Pappas PG, Morgan J, Hajjeh RA, Transplant Associated Infection Surveillance Network (TRANSNET) (2003) Prospective surveillance for invasive fungal infections (IFIs) in hematopoietic stem cell (HSCTs) and solid organ transplant recipients (SOTs) in the United States. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 458, M-1010
37.
Zurück zum Zitat Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, Edwards JE (2004) Infectious Diseases Society of America. Guidelines for treatment of candidiasis. Clin Infect Dis 38:161–189CrossRefPubMed Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, Edwards JE (2004) Infectious Diseases Society of America. Guidelines for treatment of candidiasis. Clin Infect Dis 38:161–189CrossRefPubMed
38.
Zurück zum Zitat Patterson TF, Kirkpatrick WR, White M et al (2000) Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group. Medicine (Baltimore) 79:250–260 Patterson TF, Kirkpatrick WR, White M et al (2000) Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group. Medicine (Baltimore) 79:250–260
39.
Zurück zum Zitat Redding SW, Kirkpatrick WR, Coco BJ, White WS, Patterson TF, Marr KA (2003) Oral colonization as a source of Candida glabrata candidemia with allogeneic bone marrow transplant. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 458, M-1011 Redding SW, Kirkpatrick WR, Coco BJ, White WS, Patterson TF, Marr KA (2003) Oral colonization as a source of Candida glabrata candidemia with allogeneic bone marrow transplant. In: 43rd ICAAC abstracts, American Society for Microbiology, September 2003, p 458, M-1011
40.
Zurück zum Zitat Rex JH, Bennett JE, Sugar AM, Pappas PG, van der Horst CM, Edwards JE, Washburn RG, Scheld WM, Karchmer AW, Dine AP et al (1994) A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. Candidemia Study Group and the National Institute. N Engl J Med 331:1325–1330CrossRefPubMed Rex JH, Bennett JE, Sugar AM, Pappas PG, van der Horst CM, Edwards JE, Washburn RG, Scheld WM, Karchmer AW, Dine AP et al (1994) A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. Candidemia Study Group and the National Institute. N Engl J Med 331:1325–1330CrossRefPubMed
41.
Zurück zum Zitat Rex JH, Pappas PG, Karchmer AW, Sobel J, Edwards JE, Hadley S, Brass C et al (2003) A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects. Clin Infect Dis 36:1221–1228CrossRefPubMed Rex JH, Pappas PG, Karchmer AW, Sobel J, Edwards JE, Hadley S, Brass C et al (2003) A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects. Clin Infect Dis 36:1221–1228CrossRefPubMed
42.
Zurück zum Zitat Marr KA, Balajee SA, McLaughlin L, Tabouret M, Bentsen C, Walsh TJ (2004) Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance. J Infect Dis 190:641-649 Marr KA, Balajee SA, McLaughlin L, Tabouret M, Bentsen C, Walsh TJ (2004) Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance. J Infect Dis 190:641-649
43.
Zurück zum Zitat Schmitt-Hoffmann AH, Roos B, Heep M, Weidekamm E, Beglinger C. Pharmacokinetics of BAL4815, a new azole antifungal, after administration of single ascending oral doses of its pro-drug BAL8557. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 30, A-1568 Schmitt-Hoffmann AH, Roos B, Heep M, Weidekamm E, Beglinger C. Pharmacokinetics of BAL4815, a new azole antifungal, after administration of single ascending oral doses of its pro-drug BAL8557. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 30, A-1568
44.
Zurück zum Zitat Schranz JA, Krause D, Goldstein BP, Henkel T (2003) Efficacy of Anidulafungin (ANID) for the treatment of candidemia. In: 43rd ICAAC abstracts, American Society for Microbiology, Sept 2003, p 448, M-971 Schranz JA, Krause D, Goldstein BP, Henkel T (2003) Efficacy of Anidulafungin (ANID) for the treatment of candidemia. In: 43rd ICAAC abstracts, American Society for Microbiology, Sept 2003, p 448, M-971
45.
Zurück zum Zitat Steinbach WJ, Benjamin DK, Kontoyiannis DP, Perfect JR, Lutsar I, Marr KA, Jafri HS, Walsh TJ (2003) Invasive aspergillosis (IA) caused by Aspergillus terreus: multicenter retrospective analysis of 87 cases. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 475, M-1753 Steinbach WJ, Benjamin DK, Kontoyiannis DP, Perfect JR, Lutsar I, Marr KA, Jafri HS, Walsh TJ (2003) Invasive aspergillosis (IA) caused by Aspergillus terreus: multicenter retrospective analysis of 87 cases. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 475, M-1753
46.
Zurück zum Zitat Stute N, Kratochwille A, Zabelina T, Fehse N, Hassenpflug W, Panse J, Woltschke C, Ayuketang F, Schieder H, Renges H, von Hinüber R, Kabisch H, Zander AR, Kroge N (2003) Caspofungin is highly effective as secondary prophylaxis in allogeneic stem cell transplantation in patients with prior systemic or invasive fungal infections (abstract 3636). In: Proceedings 45th ASH 2003 Stute N, Kratochwille A, Zabelina T, Fehse N, Hassenpflug W, Panse J, Woltschke C, Ayuketang F, Schieder H, Renges H, von Hinüber R, Kabisch H, Zander AR, Kroge N (2003) Caspofungin is highly effective as secondary prophylaxis in allogeneic stem cell transplantation in patients with prior systemic or invasive fungal infections (abstract 3636). In: Proceedings 45th ASH 2003
47.
Zurück zum Zitat Troke PF, Schwartz S, Ruhnke M, Ribaud P, Corey L, Driscoll T, Fätkenheuer G, Schuler U, Thiel E, Dodell B, Lutsar I (2003) Voriconazole (VRC) therapy (Rx) in 86 patients (pts) with CNS aspergillosis (CNSA): a retrospective analysis. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 476, M-1755 Troke PF, Schwartz S, Ruhnke M, Ribaud P, Corey L, Driscoll T, Fätkenheuer G, Schuler U, Thiel E, Dodell B, Lutsar I (2003) Voriconazole (VRC) therapy (Rx) in 86 patients (pts) with CNS aspergillosis (CNSA): a retrospective analysis. In: 43rd ICAAC Abstracts, American Society for Microbiology, September 2003, p 476, M-1755
48.
Zurück zum Zitat Ullmann A, Van Burik JA, McSweeney P, Ratanatharathorn V, Raymond J, de Morais VL, McGuirk J, Lau W, Facklam D, Koblinger S, Reusch M, Marr K, Patterson TF, Denning DW (2003) An open phase II study of the efficacy of micafungin (FK463) alone and in combination for the treatment of invasive aspergillosis (IA) in adults and children (abstract). In: 13th ECCMID 10–13 May 2003 Ullmann A, Van Burik JA, McSweeney P, Ratanatharathorn V, Raymond J, de Morais VL, McGuirk J, Lau W, Facklam D, Koblinger S, Reusch M, Marr K, Patterson TF, Denning DW (2003) An open phase II study of the efficacy of micafungin (FK463) alone and in combination for the treatment of invasive aspergillosis (IA) in adults and children (abstract). In: 13th ECCMID 10–13 May 2003
49.
Zurück zum Zitat Walsh TJ, Finberg RW, Arndt C et al (1999) Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. N Engl J Med 340:764–771 Walsh TJ, Finberg RW, Arndt C et al (1999) Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. N Engl J Med 340:764–771
50.
Zurück zum Zitat Walsh TJ, Roden M, Nelson L, Knudsen T, Venzon D, Segal B, Barrett J, Childs R (2002) Invasive fungal infections complicating non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT). In: Proceedings 42nd ICAAC, San Diego, 27–30 September 2002, M-1233 Walsh TJ, Roden M, Nelson L, Knudsen T, Venzon D, Segal B, Barrett J, Childs R (2002) Invasive fungal infections complicating non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT). In: Proceedings 42nd ICAAC, San Diego, 27–30 September 2002, M-1233
51.
Zurück zum Zitat Walsh TJ, Pappas P, Winston DJ et al (2002) Voriconazole versus liposomal amphotericin B for empirical antifungal therapy of persistently febrile neutropenic patients: a randomized, international, multicenter trial. N Engl J Med 340:764–771 Walsh TJ, Pappas P, Winston DJ et al (2002) Voriconazole versus liposomal amphotericin B for empirical antifungal therapy of persistently febrile neutropenic patients: a randomized, international, multicenter trial. N Engl J Med 340:764–771
52.
Zurück zum Zitat Walsh TJ, Patterson T, Langston A, van Burik J, Louie A, Herbrecht R, Hadley S, Perfect J, Hsu C, Gogate J, Hardalo C, Patino H, Pedicone L, Corcoran G, Raad I (2003) Posaconazole for treatment of invasive aspergillosis in patients who are refractory to or intolerant of conventional therapy: an externally controlled blinded trial (abstract 682). In: Proceedings 45th ASH 2003 Walsh TJ, Patterson T, Langston A, van Burik J, Louie A, Herbrecht R, Hadley S, Perfect J, Hsu C, Gogate J, Hardalo C, Patino H, Pedicone L, Corcoran G, Raad I (2003) Posaconazole for treatment of invasive aspergillosis in patients who are refractory to or intolerant of conventional therapy: an externally controlled blinded trial (abstract 682). In: Proceedings 45th ASH 2003
53.
Zurück zum Zitat Walsh TJ, Teppler H, Donowitz GR, Maertens JA, Baden LR, Dmoszynska A, Cornely OA, Bourque MR, Lupinacci R, Sable C, De Pauw B (2004) Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in persistent febrile neutropenic patients. N Engl J Med 351:1391–1402 Walsh TJ, Teppler H, Donowitz GR, Maertens JA, Baden LR, Dmoszynska A, Cornely OA, Bourque MR, Lupinacci R, Sable C, De Pauw B (2004) Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in persistent febrile neutropenic patients. N Engl J Med 351:1391–1402
54.
Zurück zum Zitat Winston DJ, Maziarz RT, Chandrasekar PH, Lazarus HM, Goldman M, Leitz G, Territo MC (2003) Long-term antifungal prophylaxis in allogeneic bone marrow transplant patients: a multicenter, randomized trial of intravenous/oral itraconazole versus intravenous/oral fluconazole. Ann Intern Med 138:705–713 Winston DJ, Maziarz RT, Chandrasekar PH, Lazarus HM, Goldman M, Leitz G, Territo MC (2003) Long-term antifungal prophylaxis in allogeneic bone marrow transplant patients: a multicenter, randomized trial of intravenous/oral itraconazole versus intravenous/oral fluconazole. Ann Intern Med 138:705–713
55.
Zurück zum Zitat Winston DJ, Emmanouilides C, Bartoni K, Schiller GJ, Paquette R, Territo MC (2003) Elimination of Aspergillus as a significant pathogen in an allogeneic hematopoietic stem cell transplant program after introduction of routine long-term itraconazole prophylaxis (abstract 685). In: Proceedings 45th ASH 2003 Winston DJ, Emmanouilides C, Bartoni K, Schiller GJ, Paquette R, Territo MC (2003) Elimination of Aspergillus as a significant pathogen in an allogeneic hematopoietic stem cell transplant program after introduction of routine long-term itraconazole prophylaxis (abstract 685). In: Proceedings 45th ASH 2003
56.
Zurück zum Zitat Yadav SP, Chen S, Halliday C, Shaw PJ (2003) Serial Aspergillus PCR assays for the early diagnosis of invasive aspergillosis in children with leukemia or undergoing stem cell transplantation (abstract 3621). In: Proceedings 45th ASH 2003 Yadav SP, Chen S, Halliday C, Shaw PJ (2003) Serial Aspergillus PCR assays for the early diagnosis of invasive aspergillosis in children with leukemia or undergoing stem cell transplantation (abstract 3621). In: Proceedings 45th ASH 2003
57.
Zurück zum Zitat Rosen GP, Nielsen K, Pediatrics TM (2003) Fungal infections in pediatric bone marrow transplant recipients and non-transplant oncology patients (abstract 5535). In: Proceedings 45th ASH 2003 Rosen GP, Nielsen K, Pediatrics TM (2003) Fungal infections in pediatric bone marrow transplant recipients and non-transplant oncology patients (abstract 5535). In: Proceedings 45th ASH 2003
Metadaten
Titel
Recent developments in the management of invasive fungal infections in patients with hematological malignancies
verfasst von
Meinolf Karthaus
Oliver A. Cornely
Publikationsdatum
01.04.2005
Erschienen in
Annals of Hematology / Ausgabe 4/2005
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-004-0986-0

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