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01.08.2013 | Original Article

Apoptosis-related Fas and FasL gene polymorphisms’ associations with knee osteoarthritis

verfasst von: Melek Sezgin, İbrahim Ömer Barlas, Seyfi Yıldır, Gözde Türköz, Handan Çamdeviren Ankaralı, Günşah Şahin, Mehmet Emin Erdal

Erschienen in: Rheumatology International | Ausgabe 8/2013

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Abstract

To investigate the associations between Fas and FasL gene polymorphisms and susceptibility to knee osteoarthritis. Genomic DNA was obtained from 146 patients with knee osteoarthritis and 102 healthy controls. Genotype distributions and allelic frequencies of four polymorphisms of Fas (-670 G>A rs1800682, -1377 G>A rs2234767) and FasL (IVS2nt-124 A>G rs5030772, -844 T>C rs763110) genes were compared between the groups. Thereafter, this association was investigated between patients and controls of the same sex. There were significant differences between patients with knee osteoarthritis and controls regarding the genotype distributions and allelic frequencies of Fas-1377 G>A polymorphism (P = 0.0001 and P = 0.005, respectively). The Fas-1377 GG genotype and G allele were significantly more frequent in patients with knee osteoarthritis than in controls. Genotype distributions and allelic frequencies of Fas-670 G>A, FasL-844 T>C, and FasL IVS2nt-124 A>G polymorphisms did not differ between the groups (P > 0.05). However, there were no significant differences between patients and controls of the same sex (P > 0.05). These findings suggest that the Fas-1377 G>A polymorphism in the Fas gene related with apoptosis may contribute to susceptibility to knee osteoarthritis in the Turkish population. There is a need for further studies to evaluate the role of apoptosis in large cohorts.

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Titel: Apoptosis-related Fas and FasL gene polymorphisms’ associations with knee osteoarthritis
verfasst von: Melek Sezgin
İbrahim Ömer Barlas
Seyfi Yıldır
Gözde Türköz
Handan Çamdeviren Ankaralı
Günşah Şahin
Mehmet Emin Erdal
Publikationsdatum: 01.08.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 8/2013
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-013-2688-1

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