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01.05.2015 | Original Article - Epidemiology of RMD

Effects of cigarette smoking on early arthritis: a cross-sectional study—data from the Argentine Consortium for Early Arthritis (CONAART)

verfasst von: María Jezabel Haye Salinas, Soledad Retamozo, Ana Cecilia Alvarez, Hernán Maldonado Ficco, Fernando Dal Pra, Gustavo Citera, Mariana Benegas, Rafael Chaparro del Moral, Oscar Rillo, Anastasia Secco, Lucila Marino Claverie, Antonio Catalan Pellet, Josefina Marcos, Mercedes Argentina García, Juan Carlos Marcos, Ana Barbaglia, Verónica Bellomio, Alberto Berman, Cristian Quiroz, Enrique R Soriano, Federico Ceccato, Sergio Paira, Doralia Vazquez, Vicente Ricardo Juarez, Edson Javier Velozo, Gabriela Salvatierra, Francisco Caeiro

Erschienen in: Rheumatology International | Ausgabe 5/2015

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Abstract

Our objective was to analyze the effects of cigarette smoking on disease activity, functional capacity, radiographic damage, serology and presence of extraarticular manifestations in patients with rheumatoid arthritis and undifferentiated arthritis. This is a cross-sectional study of 1,305 patients (729 with rheumatoid arthritis and 576 with undifferentiated arthritis) from CONAART, the Argentine Consortium for Early Arthritis that includes patients older than 16 years with <2 years of disease. Sociodemographic data, clinical characteristics of the disease and smoking history were collected. In patients with rheumatoid arthritis the disease activity score of 28 joints was 5.4 ± 1.3 in current smokers, 5.2 ± 1.4 in former smokers and 5.1 ± 1.4 in never smokers (p = 0.011). The simple erosion narrowing score was higher in current smokers and former smokers than in never smokers (M 14.0, R _Q 6.0–21.0; M 15.0, R _Q 7.0–24.0; M 10.0, R _Q 5.0–17.0; p = 0.006). Current smokers had higher rheumatoid factor titer (M 160.0, R _Q 80.0–341.0) than former smokers (M 146.8, R _Q 6.03–255.5) and never smokers (M 15.0, R _Q 9.0–80.0) (p = 0.004). The variable independently associated with tobacco exposure was simple erosion narrowing score (OR = 1.03, 95 % CI 1.00–1.05; p = 0.012). In patients with undifferentiated arthritis, an association between smoking status and parameters of activity or radiographic damage was not observed. Neither was tobacco exposure related to the presence of extraarticular manifestations or to the degree of disability in any of the two groups of patients. No relation was found between disease activity and severity, and number of packs smoked per year. Tobacco.

Criswell LA, Saag KG, Mikuls TR, Cerhan JR, Merlino LA, Lum RF et al (2006) Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women. Ann Rheum Dis 65:1163–1167CrossRefPubMedCentralPubMed

de Hair MJ, Landewé RB, van de Sande MG, van Schaardenburg D, van Baarsen LG, Gerlag DM et al (2013) Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis 72:1654–1658CrossRefPubMedCentralPubMed

Di Giuseppe D, Orsini N, Alfredsson L, Askling J, Wolk A (2013) Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women. Arthritis Res Ther 15:R56CrossRefPubMedCentralPubMed

Bergström U, Jacobsson LT, Nilsson JÅ, Wirfält E, Turesson C (2013) Smoking, low formal level of education, alcohol consumption, and the risk of rheumatoid arthritis. Scand J Rheumatol 42:123–130CrossRefPubMed

Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J et al (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54:38–46CrossRefPubMed

Klareskoga L, Padyukova L, Alfredsson L (2007) Smoking as a trigger for inflammatory rheumatic diseases. Curr Opin Rheumatol 19:49–54CrossRef

Karlson EW, Chang SC, Cui J, Chibnik LB, Fraser PA, De Vivo I et al (2010) Gene environment interaction between HLA DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. Ann Rheum Dis 69:54–60CrossRefPubMedCentralPubMed

Michou L, Teixeira VH, Pierlot C, Lasbleiz S, Bardin T, Dieudé P et al (2008) Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis. Ann Rheum Dis 67:466–470CrossRefPubMed

Källberg H, Ding B, Padyukov L, Bengtsson C, Rönnelid J, Klareskog L et al (2011) Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann Rheum Dis 70:508–511CrossRefPubMedCentralPubMed

10.

Saag KG, Cerhan JR, Kolluri S, Ohashi K, Hunninghake GW, Schwartz DA (1997) Cigarette smoking and rheumatoid arthritis severity. Ann Rheum Dis 56:463–469CrossRefPubMedCentralPubMed

11.

Lee DM, Phillips R, Hagan EM, Chibnik LB, Costenbader KH, Schur PH (2009) Quantifying anti-CCP titer: clinical utility and association with tobacco exposure in patients with rheumatoid arthritis. Ann Rheum Dis 68:201–208CrossRefPubMed

12.

Linn-Rasker SP, van der Helm-van Mil AH, van Gaalen FA, Kloppenburg M, de Vries RR, le Cessie S et al (2006) Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA–DRB1 shared epitope alleles. Ann Rheum Dis 65:366–371CrossRefPubMedCentralPubMed

13.

Nyhall-Wahlin BM, Petersson IF, Nilsson JA, Jacobsson LTH, Turesson C et al (2009) High disease activity disability burden and smoking predict severe extra-articular manifestations in early rheumatoid arthritis. Rheumatology 48:416–420CrossRefPubMed

14.

Harrison BJ, Silman AJ, Wiles NJ, Scott DGI, Symmons DPM (2001) The association of cigarette smoking with disease outcome in patients with early inflammatory polyarthritis. Arthritis Rheum 44:323–330CrossRefPubMed

15.

Mikuls TR, Hughes LB, Westfall AO, Holers VM, Parrish L, van der Heijde D et al (2008) Cigarette smoking, disease severity and autoantibody expression in African Americans with recent-onset rheumatoid arthritis. Ann Rheum Dis 67:1529–1534CrossRefPubMedCentralPubMed

16.

Rojas-Serrano J, Pérez LL, García CG, Moctezuma F, Álvarez-Hernández E, Vázquez-Mellado J et al (2011) Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study. Clin Rheumatol 30:1589–1593CrossRefPubMed

17.

Marcos J, Waimann C, Dal Pra F, Hogrefe J, Retamozo S, Caeiro F et al (2011) General characteristics of an early arthritis cohort in Argentina. Rheumatology 50:110–116CrossRefPubMed

18.

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324CrossRefPubMed

19.

Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight joint count. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44–48CrossRefPubMed

20.

Citera G, Arriola MS, Maldonado-Cocco JA, Rosemffet MG, Sánchez MM, Goñi MA et al (2004) Validation and cross-cultural adaptation of an Argentine Spanish version of the Health Assessment Questionnaire Disability Index. J Clin Rheumatol 10:110–115CrossRefPubMed

21.

Van der Heijde D, Dankert T, Nieman F, Rau R, Boers M (1999) Reliability and sensitivity to change of a simplification of the Sharp van der Heijde radiological assessment in rheumatoid arthritis. Rheumatology (Oxford) 38:941–947CrossRef

22.

Manfredsdottir VF, Vikingsdottir T, Jonsson T, Geirsson AJ, Kjartansson O, Heimisdottir M et al (2006) The effects of tobacco smoking and rheumatoid factor seropositivity on disease activity and joint damage in early rheumatoid arthritis. Rheumatology 45:734–740CrossRefPubMed

23.

Papadopoulos NG, Alamanos Y, Voulgari PV, Epagelis EK, Tsifetaki N, Drosos AA (2005) Does cigarette smoking influence disease expression, activity and severity in early rheumatoid arthritis patients. Clin Exp Rheumatol 23:861–866PubMed

24.

Finckh A, Dehler S, Costenbader KH, Gabay C, on behalf of the Swiss Clinical Quality Management project for RA (SCQM) (2007) Cigarette smoking and radiographic progression in rheumatoid arthritis. Ann Rheum Dis 66:1066–1071CrossRefPubMedCentralPubMed

25.

Taylor LH, Twigg S, Worthington J, Emery P, Morgan AW, Wilson AG et al (2013) Metaanalysis of the association of smoking and ptpn22 r620w genotype on autoantibody status and radiological erosions in rheumatoid arthritis. J Rheumatol 40:1048–1053CrossRefPubMed

26.

Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L et al (2003) Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case–control study, using incident cases. Ann Rheum Dis 62:835–841CrossRefPubMedCentralPubMed

27.

Fisher MC, Hochberg MC, El-Taha M, Kremer JM, Peng C, Greenberg JD (2012) Smoking, smoking cessation, and disease activity in a large cohort of patients with rheumatoid arthritis. J Rheumatol 39:904–909CrossRefPubMed

28.

Andersson MLE, Bergman S, Söderlin MK (2012) The effect of stopping smoking on disease activity in rheumatoid arthritis (RA). Data from BARFOT, a multicenter study of early RA. Open Rheumatol J 6:303–309CrossRefPubMedCentralPubMed

29.

Suzuki A, Yamada R, Yamamoto K (2007) Citrullination by peptidylarginine deiminase in rheumatoid arthritis. Ann N Y Acad Sci 1108:323–339CrossRefPubMed

30.

Foocharoen C, Nanagara R, Suwannaroj S, Mahakkanukrauh A (2011) Clinical features and disease outcomes of undifferentiated arthritis in Thailand. Int J Rheum Dis 14:14–21CrossRef

31.

Chung HY, Machado P, van der Heijde D, D’Agostino MA, Dougados M (2012) Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health-related quality of life: results from the DESIR cohort. Ann Rheum Dis 71:809–816CrossRefPubMed

32.

Li W, Han J, Qureshi AA (2012) Smoking and risk of incident psoriatic arthritis in US women. Ann Rheum Dis 71:804–808CrossRefPubMedCentralPubMed

Titel: Effects of cigarette smoking on early arthritis: a cross-sectional study—data from the Argentine Consortium for Early Arthritis (CONAART)
verfasst von: María Jezabel Haye Salinas
Soledad Retamozo
Ana Cecilia Alvarez
Hernán Maldonado Ficco
Fernando Dal Pra
Gustavo Citera
Mariana Benegas
Rafael Chaparro del Moral
Oscar Rillo
Anastasia Secco
Lucila Marino Claverie
Antonio Catalan Pellet
Josefina Marcos
Mercedes Argentina García
Juan Carlos Marcos
Ana Barbaglia
Verónica Bellomio
Alberto Berman
Cristian Quiroz
Enrique R Soriano
Federico Ceccato
Sergio Paira
Doralia Vazquez
Vicente Ricardo Juarez
Edson Javier Velozo
Gabriela Salvatierra
Francisco Caeiro
Publikationsdatum: 01.05.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 5/2015
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-014-3188-7

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