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Rheumatology International
Erschienen in: Rheumatology International 1/2021

21.11.2020 | COVID-19 | Review Zur Zeit gratis

Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management

verfasst von: Jayakanthan Kabeerdoss, Rakesh Kumar Pilania, Reena Karkhele, T. Sathish Kumar, Debashish Danda, Surjit Singh

Erschienen in: Rheumatology International | Ausgabe 1/2021

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Abstract

Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has now been reported from several countries the world over. Some of the clinical manifestations of MIS-C mimic Kawasaki disease (KD) shock syndrome. MIS-C develops 4–6 weeks following SARS-CoV-2 infection, and is presumably initiated by adaptive immune response. Though it has multisystem involvement, it is the cardiovascular manifestations that are most prominent. High titres of anti-SARS-CoV-2 antibodies are seen in these patients. As this is a new disease entity, its immunopathogenesis is not fully elucidated. Whether it has some overlap with KD is still unclear. Current treatment guidelines recommend use of intravenous immunoglobulin and high-dose corticosteroids as first-line treatment. Mortality rates of MIS-C are lower compared to adult forms of severe COVID-19 disease.
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Metadaten
Titel
Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management
verfasst von
Jayakanthan Kabeerdoss
Rakesh Kumar Pilania
Reena Karkhele
T. Sathish Kumar
Debashish Danda
Surjit Singh
Publikationsdatum
21.11.2020
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
Rheumatology International / Ausgabe 1/2021
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-020-04749-4

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