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Erschienen in:
01.12.2011 | Urogenital
Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T
Erschienen in: European Radiology | Ausgabe 12/2011
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Objective
To retrospectively evaluate the clinical significance of N-acetyl resonances at 2 ppm in in-vivo proton magnetic resonance (MR) spectroscopy for distinguishing mucinous and non-mucinous tumours in patients with ovarian masses.
Methods
MR spectroscopy was performed in patients with pathologically diagnosed ovarian tumours at 3T-MR imaging. Single-voxel MR spectroscopy data were collected from a single square volume of interest that encompassed the ovarian masses. The metabolite resonance peak areas at 2 ppm were quantified relative to unsuppressed water using a software package (LCModel).
Results
A total of 32 ovarian lesions in 32 patients were evaluated in this study. High metabolite peak at 2 ppm was observed in all nine mucinous tumours (9.71 +/− 7.46 mM), whereas low peak was observed in 14 of 23 non-mucinous tumours (3.12 +/− 1.42 mM) (p < 0.001). Using a cut off value of 4.45 mM for mucinous tumours had a sensitivity of 89%, specificity of 86%, PPV of 80%, and NPV of 92%.
Conclusion
Proton MR spectroscopy with quantitative evaluation of the metabolite at 2 ppm concentration, which may suggest the presence of mucinous material containing N-acetyl mucinous compounds, can provide helpful information in distinguishing mucinous and non-mucinous ovarian tumours.
Key Points
• MR spectroscopy helps distinguish mucinous from non-mucinous ovarian tumours.
• High N-acetyl resonance at 2 ppm is observed in ovarian mucinous tumours.
• Thus MR spectroscopy could improve management of these patients