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29.08.2016 | Original Contribution

Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion

verfasst von: Audrey J. Gaskins, Janet W. Rich-Edwards, Paige L. Williams, Thomas L. Toth, Stacey A. Missmer, Jorge E. Chavarro

Erschienen in: European Journal of Nutrition | Ausgabe 1/2018

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Abstract

Purpose

To investigate the relation between pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion (SAB).

Methods

Our prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses’ Health Study II (1991–2009). Beverage intake was assessed every 4 years using a validated questionnaire. Pregnancies were self-reported with case pregnancies lost spontaneously at <20 weeks gestation. Multivariable log-binomial regression models with generalized estimating equations were used to estimate the relative risks (RRs) and 95 % confidence intervals (CIs).

Results

There was a positive linear trend across categories of pre-pregnancy caffeine intake and risk of SAB such that women consuming >400 mg/day had 1.11 (95 % CI 0.98, 1.25) times the risk of SAB compared to women consuming <50 mg/day (p trend = 0.05). Total coffee intake had a positive, linear association with SAB. Compared to women with no pre-pregnancy coffee intake, women consuming ≥4 servings/day had a 20 % (6, 36 %) increased risk of SAB (p trend = 0.01). There was no difference in the association between caffeinated and decaffeinated coffee and risk of SAB. Pre-pregnancy intake of caffeinated tea, caffeinated soda, and decaffeinated soda had no association with SAB.

Conclusions

Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with increased risk of SAB, particularly at weeks 8–19.

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Titel: Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion
verfasst von: Audrey J. Gaskins
Janet W. Rich-Edwards
Paige L. Williams
Thomas L. Toth
Stacey A. Missmer
Jorge E. Chavarro
Publikationsdatum: 29.08.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 1/2018
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1301-2

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