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Basic Research in Cardiology
Erschienen in: Basic Research in Cardiology 3/2009

01.05.2009 | INVITED REVIEW

Vascular control in humans: focus on the coronary microcirculation

verfasst von: Yanping Liu, David D. Gutterman, MD

Erschienen in: Basic Research in Cardiology | Ausgabe 3/2009

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Abstract

Myocardial perfusion is regulated by a variety of factors that influence arteriolar vasomotor tone. An understanding of the physiological and pathophysiological factors that modulate coronary blood flow provides the basis for the judicious use of medications for the treatment of patients with coronary artery disease. Vasomotor properties of the coronary circulation vary among species. This review highlights the results of recent studies that examine the mechanisms by which the human coronary microcirculation is regulated in normal and disease states, focusing on diabetes. Multiple pathways responsible for myogenic constriction and flow-mediated dilation in human coronary arterioles are addressed. The important role of endothelium-derived hyperpolarizing factors, their interactions in mediating dilation, as well as speculation regarding the clinical significance are emphasized. Unique properties of coronary arterioles in human vs. other species are discussed.
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Metadaten
Titel
Vascular control in humans: focus on the coronary microcirculation
verfasst von
Yanping Liu
David D. Gutterman, MD
Publikationsdatum
01.05.2009
Erschienen in
Basic Research in Cardiology / Ausgabe 3/2009
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-009-0775-y

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