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01.01.2011 | Review

Control of cardiovascular differentiation by microRNAs

verfasst von: Kisho Ohtani, Stefanie Dimmeler

Erschienen in: Basic Research in Cardiology | Ausgabe 1/2011

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Abstract

MicroRNAs (miRs) are small non-coding RNAs, which control gene expression either by inducing mRNA degradation or by blocking translation, and play a crucial role in tissue homeostasis. In the cardiovascular system, miRs were shown to control cardiac hypertrophy, fibrosis and apoptosis, angiogenesis, and vessel remodeling. In addition, miRs regulate stem cell maintenance and some miRs induced cell fate decisions. This review summarizes the current insights into the control of stem cells and lineage commitment by miRs focusing specifically to the regulation of endothelial, smooth muscle, and cardiac lineage.

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Titel: Control of cardiovascular differentiation by microRNAs
verfasst von: Kisho Ohtani
Stefanie Dimmeler
Publikationsdatum: 01.01.2011
Verlag: Springer-Verlag
Erschienen in: Basic Research in Cardiology / Ausgabe 1/2011
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-010-0139-7

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