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16.11.2019 | Correspondence

YAP1-fusions in pediatric NF2-wildtype meningioma

verfasst von: Philipp Sievers, Jason Chiang, Daniel Schrimpf, Damian Stichel, Nagarajan Paramasivam, Martin Sill, Tenzin Gayden, Belen Casalini, David E. Reuss, James Dalton, Kristian W. Pajtler, Daniel Hänggi, Christel Herold-Mende, Elisabeth Rushing, Andrey Korshunov, Christian Mawrin, Michael Weller, Matthias Schlesner, Wolfgang Wick, Nada Jabado, David T. W. Jones, Stefan M. Pfister, Andreas von Deimling, David W. Ellison, Felix Sahm

Erschienen in: Acta Neuropathologica | Ausgabe 1/2020

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Excerpt

Meningioma is the most common primary central nervous system (CNS) tumor [8]. In contrast to adulthood, meningiomas are rare among children and adolescents and frequently (about 38%) occur in the context of tumor predisposition syndromes [12]. In line with the frequent inactivation of NF2 in adult meningiomas, neurofibromatosis type 2 is the most common inherited syndrome predisposing to the early development of meningiomas, which are often multiple. Other germline alterations predisposing to meningioma development are SMARCE1 [14] and SUFU mutations [1]. More recently identified drivers of meningiomas include AKT1/TRAF7, SMO, KLF4/TRAF7, and PIK3CA mutations [3, 5]. …

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Titel: YAP1-fusions in pediatric NF2-wildtype meningioma
verfasst von: Philipp Sievers
Jason Chiang
Daniel Schrimpf
Damian Stichel
Nagarajan Paramasivam
Martin Sill
Tenzin Gayden
Belen Casalini
David E. Reuss
James Dalton
Kristian W. Pajtler
Daniel Hänggi
Christel Herold-Mende
Elisabeth Rushing
Andrey Korshunov
Christian Mawrin
Michael Weller
Matthias Schlesner
Wolfgang Wick
Nada Jabado
David T. W. Jones
Stefan M. Pfister
Andreas von Deimling
David W. Ellison
Felix Sahm
Publikationsdatum: 16.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Acta Neuropathologica / Ausgabe 1/2020
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-019-02095-9

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YAP1-fusions in pediatric NF2-wildtype meningioma

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