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Archives of Orthopaedic and Trauma Surgery

Erschienen in:

01.08.2009 | Arthroscopy and Sports Medicine

Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep

verfasst von: Rupert Meller, G. Brandes, C. Drögemüller, F. Fritz, F. Schiborra, M. Fehr, S. Hankemeier, C. Krettek, C. Hurschler

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 8/2009

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Abstract

Introduction

Ruptures of the anterior cruciate ligament are being diagnosed with increasing frequency in skeletally immature individuals. It was our aim to investigate the graft remodelling process following an autologous, transphyseal reconstruction of the anterior cruciate ligament (ACL) in skeletally immature sheep. We hypothesized that the ligamentisation process in immature sheep is quicker and more complete when compared to adult sheep.

Materials and methods

Skeletally immature sheep with an age of 4 months underwent a fully transphyseal ACL reconstruction using an autologous tendon. The animals were subsequently sacrificed at 3, 6, 12 and 24 weeks following surgery. Each group was characterised histomorphometrically, by immunostaining (VEGF, SMA), by transmission electron microscopy (TEM) and biomechanically (UFS Roboter).

Results

The histomorphometric analysis and presence of VEGF and SMA positive cells demonstrated a rapid return to a ligament like structure. The biomechanical analysis revealed an anteroposterior translation that was still increased even 6 months following surgery.

Conclusion

As in adult sheep models, the remodeling of a soft tissue graft used for ACL reconstruction results in a biomechanically inferior substitute. However, the immature tissue seems to remodel faster and more complete when compared to adults.

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Titel: Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep
verfasst von: Rupert Meller
G. Brandes
C. Drögemüller
F. Fritz
F. Schiborra
M. Fehr
S. Hankemeier
C. Krettek
C. Hurschler
Publikationsdatum: 01.08.2009
Verlag: Springer-Verlag
Erschienen in: Archives of Orthopaedic and Trauma Surgery / Ausgabe 8/2009
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-008-0784-6

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Abstract

Introduction

Materials and methods

Results

Conclusion

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