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Erschienen in: Archives of Gynecology and Obstetrics 5/2009

01.05.2009 | Original Article

Feasibility and morbidity of total laparoscopic radical hysterectomy with or without pelvic limphadenectomy in obese women with stage I endometrial cancer

verfasst von: Antonio Pellegrino, Mauro Signorelli, Robert Fruscio, Annalisa Villa, Alessandro Buda, Pietro Beretta, Annalisa Garbi, Domenico Vitobello

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2009

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Abstract

Objective

The aim of this study was to describe the feasibility and morbidity rates associated with total laparoscopic radical hysterectomy (TLRH) with or without pelvic lymphadenectomy for stage I endometrial cancer in obese women.

Patients and methods

Obese patients with stage I endometrial cancer who underwent total laparoscopic radical surgery at the Department of Obstetrics and Gynecology of San Gerardo Hospital were compared to nonobese patients. The same group of obese patients was compared with patients who underwent radical laparotomic surgery. Obesity was defined as a body mass index more than 30 kg/m2.

Results

Between September 2003 and September 2007, 75 women underwent TLRH. Median age was 54 years and median body mass index was 28 kg/m2. Thirty-seven women were obese.
There were no differences between nonobese and obese women in operative, time length of parametria and pelvic nodes removed and operative or late complications. Blood loss was significantly higher in obese patients.
Comparing retrospectively laparoscopy and laparotomy in obese women treated in our center, laparotomy was associated with decreased operative time, but also with increased blood loss, transfusion rate, duration of hospitalization and frequency of post surgical complications.

Conclusions

Total laparoscopic radical hysterectomy (with pelvic lymphadenectomy) is a safe option in patients with endometrial cancer. Obesity is not a contraindication to perform a TRLH with no differences in surgical parameters between obese and nonobese population. TLRH show a significant decrease of complications compared to laparotomic radical surgery in obese women.
Literatur
1.
Zurück zum Zitat Ries LA, Eisner MP, Kosary CL et al (2001) SEER cancer statistics review, 1973–1998. Bethesda National Cancer Institute Ries LA, Eisner MP, Kosary CL et al (2001) SEER cancer statistics review, 1973–1998. Bethesda National Cancer Institute
2.
Zurück zum Zitat Boronow RC, Morrow CP, Creasman WT, Disaia PJ, Silverberg SG, Miller A et al (1984) Surgical staging in endometrial cancer: clinical-pathologic findings of a prospective study. Obstet Gynecol 63(6):825–832PubMed Boronow RC, Morrow CP, Creasman WT, Disaia PJ, Silverberg SG, Miller A et al (1984) Surgical staging in endometrial cancer: clinical-pathologic findings of a prospective study. Obstet Gynecol 63(6):825–832PubMed
4.
Zurück zum Zitat Magrina JF, Mutone NF, Weaver AL et al (1999) Laparoscopic lymphadenectomy and vaginal or laparoscopic hysterectomy with bilateral salpingo-oophorectomy for endometrial cancer: morbidity and survival. Am J Obstet Gynecol 181:376–381. doi:10.1016/S0002-9378(99)70565-X PubMedCrossRef Magrina JF, Mutone NF, Weaver AL et al (1999) Laparoscopic lymphadenectomy and vaginal or laparoscopic hysterectomy with bilateral salpingo-oophorectomy for endometrial cancer: morbidity and survival. Am J Obstet Gynecol 181:376–381. doi:10.​1016/​S0002-9378(99)70565-X PubMedCrossRef
5.
Zurück zum Zitat Magrina JF, Weaver AL (2004) Laparoscopic treatment of endometrial cancer: five year recurrence and survival rates. Eur J Gynaecol Oncol 25:439–441PubMed Magrina JF, Weaver AL (2004) Laparoscopic treatment of endometrial cancer: five year recurrence and survival rates. Eur J Gynaecol Oncol 25:439–441PubMed
7.
Zurück zum Zitat Zullo F, Palomba S, Russo T, Falbo A, Costantino M, Tolino A et al (2005) A prospective randomized comparison between laparoscopic and laparotomic approaches in women with early stage endometrial cancer: a focus on the quality of life. Am J Obstet Gynecol 193(4):1344–1352. doi:10.1016/j.ajog.2005.02.131 PubMedCrossRef Zullo F, Palomba S, Russo T, Falbo A, Costantino M, Tolino A et al (2005) A prospective randomized comparison between laparoscopic and laparotomic approaches in women with early stage endometrial cancer: a focus on the quality of life. Am J Obstet Gynecol 193(4):1344–1352. doi:10.​1016/​j.​ajog.​2005.​02.​131 PubMedCrossRef
8.
Zurück zum Zitat Piver MS, Rutledge F, Smith JP (1974) Five classes of extended hysterectomy for women with cervical cancer. Obstet Gynecol 44:265–272PubMed Piver MS, Rutledge F, Smith JP (1974) Five classes of extended hysterectomy for women with cervical cancer. Obstet Gynecol 44:265–272PubMed
9.
Zurück zum Zitat Spirtos NM, Eisenkop SM, Schlaerth JB, Ballon SC (2002) Laparoscopic radical hysterectomy (type III) with aortic and pelvic lymphadenectomy in patients with stage I cervical cancer: surgical morbidity and intermediate follow-up. Am J Obstet Gynecol 187(2):340–348. doi:10.1067/mob.2002.123035 PubMedCrossRef Spirtos NM, Eisenkop SM, Schlaerth JB, Ballon SC (2002) Laparoscopic radical hysterectomy (type III) with aortic and pelvic lymphadenectomy in patients with stage I cervical cancer: surgical morbidity and intermediate follow-up. Am J Obstet Gynecol 187(2):340–348. doi:10.​1067/​mob.​2002.​123035 PubMedCrossRef
10.
Zurück zum Zitat Hsieh YY, Lin WC, Chang CC, Yeh LS, Hsu TY, Tsai HD (1998) Laparoscopic radical hysterectomy with low paraaortic, subaortic and pelvic lymphadenectomy. Results of short-term follow-up. J Reprod Med 43:528–534PubMed Hsieh YY, Lin WC, Chang CC, Yeh LS, Hsu TY, Tsai HD (1998) Laparoscopic radical hysterectomy with low paraaortic, subaortic and pelvic lymphadenectomy. Results of short-term follow-up. J Reprod Med 43:528–534PubMed
11.
Zurück zum Zitat Gemignani ML, Curtin JP, Zelmanovich J, Patel DA, Venkatraman E, Barakat RR (1999) Laparoscopic-assisted vaginal hysterectomy for endometrial cancer: clinical outcomes and hospital charges. Gynecol Oncol 73:5–11. doi:10.1006/gyno.1998.5311 PubMedCrossRef Gemignani ML, Curtin JP, Zelmanovich J, Patel DA, Venkatraman E, Barakat RR (1999) Laparoscopic-assisted vaginal hysterectomy for endometrial cancer: clinical outcomes and hospital charges. Gynecol Oncol 73:5–11. doi:10.​1006/​gyno.​1998.​5311 PubMedCrossRef
12.
Zurück zum Zitat Holub Z, Voracek J, Shomani A (1998) A comparison of laparoscopic surgery with open procedure in endometrial cancer. Eur J Gynec Oncol 9:294–296 Holub Z, Voracek J, Shomani A (1998) A comparison of laparoscopic surgery with open procedure in endometrial cancer. Eur J Gynec Oncol 9:294–296
13.
Zurück zum Zitat Holub Z (2003) The role of laparoscopy in the surgical treatment of endometrial cancer. Clin Exp Obstet Gynecol 30(1):7–12 ReviewPubMed Holub Z (2003) The role of laparoscopy in the surgical treatment of endometrial cancer. Clin Exp Obstet Gynecol 30(1):7–12 ReviewPubMed
15.
Zurück zum Zitat La Vecchia C, Parazzini F, Negri E, Fasoli M, Gentile A, Franceschi S (1991) Anthropometric indicators of endometrial cancer risk. Eur J Cancer 27(4):487–490PubMedCrossRef La Vecchia C, Parazzini F, Negri E, Fasoli M, Gentile A, Franceschi S (1991) Anthropometric indicators of endometrial cancer risk. Eur J Cancer 27(4):487–490PubMedCrossRef
16.
Zurück zum Zitat Shoff SM, Newcomb PA (1998) Diabetes, body size, and risk of endometrial cancer. Am J Epidemiol 148(3):234–240PubMed Shoff SM, Newcomb PA (1998) Diabetes, body size, and risk of endometrial cancer. Am J Epidemiol 148(3):234–240PubMed
17.
Zurück zum Zitat Pitkin RM (1976) Abdominal hysterectomy in obese women. Surg Gynecol Obstet 142:532–536PubMed Pitkin RM (1976) Abdominal hysterectomy in obese women. Surg Gynecol Obstet 142:532–536PubMed
19.
Zurück zum Zitat Ostrzenski A (1999) Laparoscopic total abdominal hysterectomy in morbidly obese women. J Reprod Med 44:853–858PubMed Ostrzenski A (1999) Laparoscopic total abdominal hysterectomy in morbidly obese women. J Reprod Med 44:853–858PubMed
21.
Zurück zum Zitat Kuoppala T, Tomas E, Heinonen PK (2004) Clinical outcome and complications of laparoscopic surgery compared with traditional surgery in women with endometrial cancer. Arch Gynecol Obstet 270(1):25–30. doi:10.1007/s00404-003-0488-7 PubMedCrossRef Kuoppala T, Tomas E, Heinonen PK (2004) Clinical outcome and complications of laparoscopic surgery compared with traditional surgery in women with endometrial cancer. Arch Gynecol Obstet 270(1):25–30. doi:10.​1007/​s00404-003-0488-7 PubMedCrossRef
22.
Zurück zum Zitat Abu-Rustum NR, Gemignani ML, Moore K, Sonoda Y, Venkatraman E, Brown C et al (2003) Total laparoscopic radical hysterectomy with pelvic lymphadenectomy using the argon-beam coagulator: pilot data and comparison to laparotomy. Gynecol Oncol 91(2):402–409. doi:10.1016/S0090-8258(03)00518-3 PubMedCrossRef Abu-Rustum NR, Gemignani ML, Moore K, Sonoda Y, Venkatraman E, Brown C et al (2003) Total laparoscopic radical hysterectomy with pelvic lymphadenectomy using the argon-beam coagulator: pilot data and comparison to laparotomy. Gynecol Oncol 91(2):402–409. doi:10.​1016/​S0090-8258(03)00518-3 PubMedCrossRef
24.
Zurück zum Zitat Pelosi MA (1994) Laparoscopically-assisted hysterectomy in women weighing 200 lb or more. Gynaecol Endosc 3:159–162 Pelosi MA (1994) Laparoscopically-assisted hysterectomy in women weighing 200 lb or more. Gynaecol Endosc 3:159–162
29.
Zurück zum Zitat Ghezzi F, Cromi A, Bergamini V, Uccella S, Beretta P, Franchi M et al (2006) Laparoscopic-assisted vaginal hysterectomy versus total laparoscopic hysterectomy for the management of endometrial cancer: a randomized clinical trial. J Minim Invasive Gynecol 13(2):114–120. doi:10.1016/j.jmig.2005.11.013 PubMedCrossRef Ghezzi F, Cromi A, Bergamini V, Uccella S, Beretta P, Franchi M et al (2006) Laparoscopic-assisted vaginal hysterectomy versus total laparoscopic hysterectomy for the management of endometrial cancer: a randomized clinical trial. J Minim Invasive Gynecol 13(2):114–120. doi:10.​1016/​j.​jmig.​2005.​11.​013 PubMedCrossRef
30.
Zurück zum Zitat Malur S, Possover M, Michels W, Schneider A (2001) Laparoscopic-assisted vaginal versus abdominal surgery in patients with endometrial cancer—a prospective randomized trial. Gynecol Oncol 80(2):239–244. doi:10.1006/gyno.2000.6069 PubMedCrossRef Malur S, Possover M, Michels W, Schneider A (2001) Laparoscopic-assisted vaginal versus abdominal surgery in patients with endometrial cancer—a prospective randomized trial. Gynecol Oncol 80(2):239–244. doi:10.​1006/​gyno.​2000.​6069 PubMedCrossRef
Metadaten
Titel
Feasibility and morbidity of total laparoscopic radical hysterectomy with or without pelvic limphadenectomy in obese women with stage I endometrial cancer
verfasst von
Antonio Pellegrino
Mauro Signorelli
Robert Fruscio
Annalisa Villa
Alessandro Buda
Pietro Beretta
Annalisa Garbi
Domenico Vitobello
Publikationsdatum
01.05.2009
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2009
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-008-0790-5

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