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European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.09.2010 | Review Article

Etiopathogenesis of otosclerosis

verfasst von: Tamás Karosi, István Sziklai

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 9/2010

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Abstract

The objectives of our study was to review our current knowledge of the etiopathogenesis of otosclerotic bone remodeling including genetics, viral infection, autoimmunity and inflammation and to discuss disease pathogenesis with relevance to pharmacotherapy. Relevant publications on the etiopathogenesis, molecular biology, genetics and histopathology of otosclerosis from 1984 to 2009 were analyzed. Otosclerosis is a bone remodeling disorder of the human otic capsule; however, the etiopathogenesis remains unclear. Genetic predisposition, disturbed bone metabolism, persistent measles virus infection, autoimmunity, and hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. Since diagnosis of otosclerosis is still based on histopathological examination of the removed stapes footplate, systemic prospective studies based on comprehensive histopathological and molecular biological analysis are necessary to obtain further information on the background of the disease.

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Titel: Etiopathogenesis of otosclerosis
verfasst von: Tamás Karosi
István Sziklai
Publikationsdatum: 01.09.2010
Verlag: Springer-Verlag
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 9/2010
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-010-1292-1

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