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Langenbeck's Archives of Surgery
Erschienen in: Langenbeck's Archives of Surgery 1/2014

01.01.2014 | Review Article

Immunopathogenesis of abdominal sepsis

verfasst von: Georg F. Weber, Filip K. Swirski

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 1/2014

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Abstract

Background

Sepsis is an unsolved problem worldwide, with a 30–50 % mortality rate. The recent failures of anti-TLR4, recombinant activated protein C, and anti-TNF in clinical trials indicate a need to rethink our current understanding of sepsis’s pathophysiology. While the initial immune response is crucial for effective clearance of invading pathogens, an overly exuberant host response to infection can cause septic shock, tissue damage, and death. Profuse inflammation in sepsis is frequently followed by global immunosuppression that increases susceptibility to viral and bacterial infections. Despite the dangers of immune over-response, the immune system’s anti-inflammatory activities are likely necessary to reduce the initial over-activation of the immune system.

Purpose

With this review, we want to illuminate the different aspects of immune response to sepsis and provide insight to the ongoing difficulties currently present within sepsis research.

Conclusion

Future treatment strategies for sepsis should focus on maintaining balance between pro- and anti-inflammatory immune actions in a timely manner.
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Metadaten
Titel
Immunopathogenesis of abdominal sepsis
verfasst von
Georg F. Weber
Filip K. Swirski
Publikationsdatum
01.01.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Langenbeck's Archives of Surgery / Ausgabe 1/2014
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-013-1129-7

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