nach oben

Brain Structure and Function

Erschienen in:

01.12.2005 | Original Article

Functional clusters in the human parietal cortex as revealed by an observer-independent meta-analysis of functional activation studies

verfasst von: Janpeter Nickel, Rüdiger J. Seitz

Erschienen in: Brain Structure and Function | Ausgabe 5-6/2005

Einloggen, um Zugang zu erhalten

Abstract

The human parietal cortex is a highly differentiated structure consisting of cytoarchitectonically defined subareas that are specifically connected with other cortical and subcortical areas. Based on evidence from neurophysiological studies in subhuman primates these subareas are supposed to be functionally highly specialized. Here, we reviewed 51 different neuroimaging studies on healthy subjects with activation of the parietal lobe in statistical parametric maps. Running a cluster analysis on the stereotactic coordinates of the centers of gravity of the activation areas and plotting them into Talairach space showed a high consistency of the mean activation foci for similar paradigms across different laboratories and functional imaging modalities. Our meta-analysis exposed seven distinct pairs of quite symmetrically distributed subareas of the parietal cortex of each hemisphere as well as three unpaired regions that are critically involved in the generation of limb and eye movements in egocentric and allocentric coordinates, but also in attention, memory and cognitive problem solving. These data highlights the modular organization of the human parietal lobe. By its locally interspersed distributed circuits it orchestrates specialized cognitive subfunctions interfacing perception and action. Our meta-analysis provides a new framework for understanding information processing in the human parietal cortex.

Astafiev SV, Shulman GL, Stanley CM, Snyder AZ, Van Essen DC, Corbetta M (2003) Functional organization of human intraparietal and frontal cortex for attending, looking, and pointing. J Neurosci 23:4689–4699PubMed

Azari NP, Nickel J, Wunderlich G et al (2001) Neural correlates of religious experience. Eur J Neurosci 13:1649–1652PubMedCrossRef

Binkofski F, Butler A, Buccino G et al (2003) Mirror apraxia affects the peripersonal mirror space. A combined lesion and cerebral activation study. Exp Brain Res 153:210–219PubMedCrossRef

Bonda E, Petrides M, Frey S, Evans A (1995) Neural correlates of mental transformations of the body-in-space. Proc Natl Acad Sci USA 92:11180–11184PubMedCrossRef

Bremmer F, Schlack A, Shah NJ et al (2001) Polymodal motion processing in posterior parietal and premotor cortex: a human fMRI study strongly implies equivalencies between humans and monkeys. Neuron 29:287–296PubMedCrossRef

Brett M (2002) The MNI brain and the Talairach atlas. 14-2-2002. Ref Type: Internet Communication

Caminiti R, Ferraina S, Johnson PB (1996) The sources of visual information to the primate frontal lobe: a novel role for the superior parietal lobule. Cereb Cortex 6:319–328PubMedCrossRef

Chaminade T, Decety J (2002) Leader or follower? Involvement of the inferior parietal lobule in agency. Neuroreport 13:1975–1978PubMedCrossRef

Clower DM, Hoffman JM, Votaw JR, Faber TL, Woods RP, Alexander GE (1996) Role of posterior parietal cortex in the recalibration of visually guided reaching. Nature 383:618–621PubMedCrossRef

Coull JT, Nobre AC (1998) Where and when to pay attention: the neural systems for directing attention to spatial locations and to time intervals as revealed by both PET and fMRI. J Neurosci 18:7426–7435PubMed

Decety J, Grezes J, Costes N et al (1997) Brain activity during observation of actions. Influence of action content and subject’s strategy. Brain 120(Pt 10):1763–1777PubMedCrossRef

Dehaene S, Spelke E, Pinel P, Stanescu R, Tsivkin S (1999) Sources of mathematical thinking: behavioral and brain-imaging evidence. Science 284:970–974PubMedCrossRef

Deiber MP, Passingham RE, Colebatch JG, Friston KJ, Nixon PD, Frackowiak RS (1991) Cortical areas and the selection of movement: a study with positron emission tomography. Exp Brain Res 84:393–402PubMedCrossRef

Desmurget M, Grea H, Grethe JS, Prablanc C, Alexander GE, Grafton ST (2001) Functional anatomy of nonvisual feedback loops during reaching: a positron emission tomography study. J Neurosci 21:2919–1928PubMed

Dolan RJ, Fink GR, Rolls E et al (1997) How the brain learns to see objects and faces in an impoverished context. Nature 389:596–599PubMedCrossRef

Ehrsson HH, Kuhtz-Buschbeck JP, Forssberg H (2002) Brain regions controlling nonsynergistic versus synergistic movement of the digits: a functional magnetic resonance imaging study. J Neurosci 22:5074–5080PubMed

Faillenot I, Toni I, Decety J, Gregoire MC, Jeannerod M (1997) Visual pathways for object-oriented action and object recognition: functional anatomy with PET. Cereb Cortex 7:77–85PubMedCrossRef

Farrer C, Franck N, Georgieff N, Frith CD, Decety J, Jeannerod M (2003) Modulating the experience of agency: a positron emission tomography study. Neuroimage 18:324–333PubMedCrossRef

Farrer C, Frith CD (2002) Experiencing oneself vs another person as being the cause of an action: the neural correlates of the experience of agency. Neuroimage 15:596–603PubMedCrossRef

Fletcher PC, Frith CD, Baker SC, Shallice T, Frackowiak RS, Dolan RJ (1995) The mind’s eye—precuneus activation in memory-related imagery. Neuroimage 2:195–200PubMedCrossRef

Foerster O (1936) Sensorischer Kortex. In: Bumke OFO (ed) Allgemeine Neurologie. Julius Springer Verlag, Berlin

Gerardin E, Sirigu A, Lehericy S et al (2000) Partially overlapping neural networks for real and imagined hand movements. Cereb Cortex 10:1093–1104PubMedCrossRef

Glickstein M, May JG III, Mercier BE (1985) Corticopontine projection in the macaque: the distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei. J Comp Neurol 235:343–359PubMedCrossRef

Gurd JM, Amunts K, Weiss PH et al (2002) Posterior parietal cortex is implicated in continuous switching between verbal fluency tasks: an fMRI study with clinical implications. Brain 125:1024–1038PubMedCrossRef

Hermsdorfer J, Goldenberg G, Wachsmuth C et al (2001) Cortical correlates of gesture processing: clues to the cerebral mechanisms underlying apraxia during the imitation of meaningless gestures. Neuroimage 14:149–161PubMedCrossRef

Jancke L, Kleinschmidt A, Mirzazade S, Shah NJ, Freund HJ (2001) The role of the inferior parietal cortex in linking the tactile perception and manual construction of object shapes. Cereb Cortex 11:114–121PubMedCrossRef

Jeannerod M, Arbib MA, Rizzolatti G, Sakata H (1995) Grasping objects: the cortical mechanisms of visuomotor transformation. Trends Neurosci 18:314–320PubMedCrossRef

Jessen F, Erb M, Klose U, Lotze M, Grodd W, Heun R (1999) Activation of human language processing brain regions after the presentation of random letter strings demonstrated with event-related functional magnetic resonance imaging. Neurosci Lett 270:13–16PubMedCrossRef

Kawashima R, Roland PE, O’Sullivan BT (1995) Functional anatomy of reaching and visuomotor learning: a positron emission tomography study. Cereb Cortex 5:111–122PubMedCrossRef

Kertzman C, Schwarz U, Zeffiro TA, Hallett M (1997) The role of posterior parietal cortex in visually guided reaching movements in humans. Exp Brain Res 114:170–183PubMedCrossRef

Konen CS, Kleiser R, Wittsack HJ, Bremmer F, Seitz RJ (2004) The encoding of saccadic eye movements within human posterior parietal cortex. Neuroimage 22:304–314PubMedCrossRef

Kuhtz-Buschbeck JP, Ehrsson HH, Forssberg H (2001) Human brain activity in the control of fine static precision grip forces: an fMRI study. Eur J Neurosci 14:382–390PubMedCrossRef

Lancaster JL (2000) Talairach Daemon. Ref Type: Internet Communication

Leiguarda RC, Marsden CD (2000) Limb apraxias: higher-order disorders of sensorimotor integration. Brain 123(Pt 5):860–879PubMedCrossRef

Makuuchi M, Kaminaga T, Sugishita M (2003) Both parietal lobes are involved in drawing: a functional MRI study and implications for constructional apraxia. Brain Res Cogn Brain Res 16:338–347PubMedCrossRef

Medendorp WP, Goltz HC, Vilis T, Crawford JD (2003) Gaze-centered updating of visual space in human parietal cortex. J Neurosci 23:6209–6214PubMed

Mesulam MM (1981) A cortical network for directed attention and unilateral neglect. Ann Neurol 10:309–325PubMedCrossRef

Middleton FA, Strick PL (2000) Basal ganglia and cerebellar loops: motor and cognitive circuits. Brain Res Brain Res Rev 31:236–250PubMedCrossRef

Milner AD, Goodale MA (1993) Visual pathways to perception and action. Prog Brain Res 95:317–337PubMedCrossRef

Owen AM, Doyon J, Petrides M, Evans AC (1996) Planning and spatial working memory: a positron emission tomography study in humans. Eur J Neurosci 8:353–364PubMedCrossRef

Pardo JV, Fox PT, Raichle ME (1991) Localization of a human system for sustained attention by positron emission tomography. Nature 349:61–64PubMedCrossRef

Parsons LM, Fox PT, Downs JH et al (1995) Use of implicit motor imagery for visual shape discrimination as revealed by PET. Nature 375:54–58PubMedCrossRef

Paulesu E, Frith CD, Frackowiak RS (1993) The neural correlates of the verbal component of working memory. Nature 362:342–345PubMedCrossRef

Perry RJ, Zeki S (2000) The neurology of saccades and covert shifts in spatial attention: an event-related fMRI study. Brain 123(Pt 11):2273–2288PubMedCrossRef

Pesenti M, Zago L, Crivello F et al (2001) Mental calculation in a prodigy is sustained by right prefrontal and medial temporal areas. Nat Neurosci 4:103–107PubMedCrossRef

Petrides M, Alivisatos B, Meyer E, Evans AC (1993) Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proc Natl Acad Sci USA 90:878–882PubMedCrossRef

Petrides M, Pandya DN (1984) Projections to the frontal cortex from the posterior parietal region in the rhesus monkey. J Comp Neurol 228:105–116PubMedCrossRef

Rizzolatti G, Luppino G, Matelli M (1998) The organization of the cortical motor system: new concepts. Electroencephalogr Clin Neurophysiol 106:283–296PubMedCrossRef

Rowe JB, Toni I, Josephs O, Frackowiak RS, Passingham RE (2000) The prefrontal cortex: response selection or maintenance within working memory? Science 288:1656–1660PubMedCrossRef

Ruby P, Decety J (2001) Effect of subjective perspective taking during simulation of action: a PET investigation of agency. Nat Neurosci 4:546–550PubMed

Rushworth MF, Paus T, Sipila PK (2001) Attention systems and the organization of the human parietal cortex. J Neurosci 21:5262–5271PubMed

Sakai K, Hikosaka O, Takino R, Miyauchi S, Nielsen M, Tamada T (2000) What and when: parallel and convergent processing in motor control. J Neurosci 20:2691–2700PubMed

Schwarz C, Thier P (1999) Binding of signals relevant for action: towards a hypothesis of the functional role of the pontine nuclei. Trends Neurosci 22:443–451PubMedCrossRef

Seitz RJ, Binkofski F (2003) Modular organization of parietal lobe functions as revealed by functional activation studies. Adv Neurol 93:281–292PubMed

Seitz RJ, Stephan KM, Binkofski F (2000) Control of action as mediated by the human frontal lobe. Exp Brain Res 133:71–80PubMedCrossRef

Sereno MI, Pitzalis S, Martinez A (2001) Mapping of contralateral space in retinotopic coordinates by a parietal cortical area in humans. Science 294:1350–1354PubMedCrossRef

Shikata E, Hamzei F, Glauche V et al (2001) Surface orientation discrimination activates caudal and anterior intraparietal sulcus in humans: an event-related fMRI study. J Neurophysiol 85:1309–1314PubMed

Simon O, Mangin JF, Cohen L, Le Bihan D, Dehaene S (2002) Topographical layout of hand, eye, calculation, and language-related areas in the human parietal lobe. Neuron 33:475–487PubMedCrossRef

Stoeckel MC, Weder B, Binkofski F, Buccino G, Shah NJ, Seitz RJ (2003) A fronto-parietal circuit for tactile object discrimination: an event-related fMRI study. Neuroimage 19:1103–1114PubMedCrossRef

Suchan B, Yaguez L, Wunderlich G et al (2002) Neural correlates of visuospatial imagery. Behav Brain Res 131:163–168PubMedCrossRef

Suchan B, Yaguez L, Wunderlich G et al (2002) Hemispheric dissociation of visual-pattern processing and visual rotation. Behav Brain Res 136:533–544PubMedCrossRef

Taira M, Nose I, Inoue K, Tsutsui K (2001) Cortical areas related to attention to 3D surface structures based on shading: an fMRI study. Neuroimage 14:959–966PubMedCrossRef

Talairach JTP (1988) Co-planar stereotaxic atlas of the human brain 3-dimensional proportional system: an approach to cerebral imaging. Thieme, Stuttgart

Ungerleider LG, Haxby JV (1994) ’What’ and ’where’ in the human brain. Curr Opin Neurobiol 4:157–165PubMedCrossRef

Vandenberghe R, Price C, Wise R, Josephs O, Frackowiak RS (1996) Functional anatomy of a common semantic system for words and pictures. Nature 383:254–256PubMedCrossRef

Van Essen DC, Anderson CH, Felleman DJ (1992) Information processing in the primate visual system: an integrated systems perspective. Science 255:419–423PubMedCrossRef

Weiss PH, Marshall JC, Wunderlich G et al (2000) Neural consequences of acting in near versus far space: a physiological basis for clinical dissociations. Brain 123(Pt 12):2531–2541PubMedCrossRef

Zago L, Pesenti M, Mellet E, Crivello F, Mazoyer B, Tzourio-Mazoyer N (2001) Neural correlates of simple and complex mental calculation. Neuroimage 13:314–327PubMedCrossRef

Zilles K, Palomero-Gallagher N (2001) Cyto-, myelo-, and receptor architectonics of the human parietal cortex. Neuroimage 14:S8–S20PubMedCrossRef

Titel: Functional clusters in the human parietal cortex as revealed by an observer-independent meta-analysis of functional activation studies
verfasst von: Janpeter Nickel
Rüdiger J. Seitz
Publikationsdatum: 01.12.2005
Verlag: Springer-Verlag
Erschienen in: Brain Structure and Function / Ausgabe 5-6/2005
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-005-0037-1

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5-6/2005

Soemmerring’s work on the nervous system: a view on brain structure and function from the late eighteenth century

Evaluation of new 18F-labeled amino acids for brain PET

Multimodal architectonic mapping of human superior temporal gyrus

Developmental mechanics of the primate cerebral cortex

Three-dimensional cytoarchitectonic analysis of the posterior bank of the human precentral sulcus