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01.11.2015 | Original Article

Maturation of preterm newborn brains: a fMRI–DTI study of auditory processing of linguistic stimuli and white matter development

verfasst von: Cristina Baldoli, Elisa Scola, Pasquale Antony Della Rosa, Silvia Pontesilli, Roberta Longaretti, Antonella Poloniato, Roberta Scotti, Valeria Blasi, Sara Cirillo, Antonella Iadanza, Rosanna Rovelli, Graziano Barera, Paola Scifo

Erschienen in: Brain Structure and Function | Ausgabe 6/2015

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Abstract

To evaluate brain development longitudinally in premature infants without abnormalities as compared to healthy full-term newborns, we assessed fMRI brain activity patterns in response to linguistic stimuli and white matter structural development focusing on language-related fibres. A total sample of 29 preterm newborns and 26 at term control newborns underwent both fMRI and DTI. Griffiths test was performed at 6 months of corrected age to assess development. Auditory fMRI data were analysed in 17 preterm newborns at three time points [34, 41 and 44 weeks of post menstrual age (wPMA)] and in 15 controls, at term. Analysis showed a distinctive pattern of cortical activation in preterm newborns up to 29 wPMA moving from early prevalent left temporal and supramarginal area activation in the preterm period, to a bilateral temporal and frontoopercular activation in the at term equivalent period and to a more fine-grained left pattern of activity at 44 wPMA. At term controls showed instead greater bilateral posterior thalamic activation. The different pattern of brain activity associated to preterm newborns mirrors their white matter maturation delay in peripheral regions of the fibres and thalamo-cortical radiations in subcortical areas of both hemispheres, pointing to different transient thalamo-cortical development due to prematurity. Evidence for functional thalamic activation and more mature subcortical tracts, including thalamic radiations, may represent the substantial gap between preterm and at term infants. The transition between bilateral temporal activations at term age and leftward activations at 44 weeks of PMA is correlated to better neuropsychological results in Griffiths test.

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Titel: Maturation of preterm newborn brains: a fMRI–DTI study of auditory processing of linguistic stimuli and white matter development
verfasst von: Cristina Baldoli
Elisa Scola
Pasquale Antony Della Rosa
Silvia Pontesilli
Roberta Longaretti
Antonella Poloniato
Roberta Scotti
Valeria Blasi
Sara Cirillo
Antonella Iadanza
Rosanna Rovelli
Graziano Barera
Paola Scifo
Publikationsdatum: 01.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 6/2015
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-014-0887-5

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