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Medical Microbiology and Immunology

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01.08.2009 | Review

What determines the success or failure of intracellular cutaneous parasites? Lessons learned from leishmaniasis

verfasst von: Marcus Maurer, Blaise Dondji, Esther von Stebut

Erschienen in: Medical Microbiology and Immunology | Ausgabe 3/2009

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Abstract

Most parasitic skin infections are averted by very efficient strategies of preventing pathogen invasion. Innate immune cells such as mast cells, macrophages and dendritic cells are responsible for detecting parasites and for recruiting proinflammatory cells that help to contain and control the pathogen at sites of infection. This induces efficient adaptive immunity, which is crucially important for parasite control. Using the example of cutaneous leishmaniasis, we highlight how the skin utilizes different strategies to prevent skin infection and how containment of the infection to the skin site may reduce the harm that otherwise may result for the entire organism.

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Titel: What determines the success or failure of intracellular cutaneous parasites? Lessons learned from leishmaniasis
verfasst von: Marcus Maurer
Blaise Dondji
Esther von Stebut
Publikationsdatum: 01.08.2009
Verlag: Springer-Verlag
Erschienen in: Medical Microbiology and Immunology / Ausgabe 3/2009
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-009-0114-9

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