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Medical Microbiology and Immunology

Medical Microbiology and Immunology OnlineFirst articles

08.01.2019 | Original Investigation

Diagnostic performance in active TB of QFT-Plus assay and co-expression of CD25/CD134 in response to new antigens of Mycobacterium tuberculosis

The new QuantiFERON-TB Gold Plus employs modified peptides optimized to elicit an IFNγ response from CD8+ cytotoxic T lymphocytes in addition to CD4+ T cells. With a view to improve the difficult identification of TB cases, we assessed the …

18.12.2018 | Original Investigation

Increased SAMHD1 transcript expression correlates with interferon-related genes in HIV-1-infected patients

Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) is a human triphosphohydrolase able to act as an HIV-1 restriction factor in non-dividing myeloid cells and quiescent CD4+ T cells [ 1 – 7 ]. Its main activity consists in limiting the …

12.12.2018 | Original Investigation

The monocytosis during human leptospirosis is associated with modest immune cell activation states

Leptospirosis is a life-threatening zoonotic disease and it has been hypothesized that the innate immune system fails to control the infection through ill-characterized mechanisms. The aim of this observational study was to better evaluate the …

27.11.2018 | Review

Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity

Staphylococcus aureus causes various health care- and community-associated infections as well as certain chronic TH2 driven inflammatory diseases. It is a potent pathogen with serious virulence and associated high morbidity. Severe pathogenicity …

09.11.2018 | Original Investigation

Immune response triggered by Trypanosoma cruzi infection strikes adipose tissue homeostasis altering lipid storage, enzyme profile and adipokine expression

Adipose tissue is a target of Trypanosoma cruzi infection being a parasite reservoir during the chronic phase in mice and humans. Previously, we reported that acute Trypanosoma cruzi infection in mice is linked to a severe adipose tissue loss …

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Medical Microbiology and Immunology covers all aspects of the interrelationship between infectious agents and their hosts. Among the major topics covered are microbial and viral pathogenesis and the immunological host response to infections. The journal also publishes information from other fields of microbiology, including mycology and parasitology.

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