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Medical Microbiology and Immunology

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01.08.2015 | Review

Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections

verfasst von: Dimitrios Nasioudis, Steven S. Witkin

Erschienen in: Medical Microbiology and Immunology | Ausgabe 4/2015

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Abstract

Neutrophil gelatinase-associated lipocalin (NGAL), an essential component of the antimicrobial innate immune system, is present in neutrophils and multiple other tissues. It prevents iron acquisition by microorganisms by sequestering iron-loaded bacterial siderophores. NGAL also modulates neutrophil functions. Its production is inducible following Toll-like receptor 4 activation and release of pro-inflammatory cytokines. NGAL is employed clinically in the diagnosis of acute kidney injury and may be useful in general in the differential diagnosis of a bacterial-mediated infectious process. Elevated levels of NGAL have been detected in the blood of patients with bacterial urinary tract infection, community-acquired pneumonia, sepsis, as well as in the cerebrospinal fluid and peritoneal fluid of patients with bacterial meningitis and peritonitis. Some bacteria have developed resistance to NGAL-mediated iron sequestration by production of modified siderophores that are not recognized by NGAL.

Andrews SC, Robinson AK, Rodríguez-Quiñones F (2003) Bacterial iron homeostasis. FEMS Microbiol Rev 27(2–3):215–237PubMed

Parrow NL, Fleming RE, Minnick MF (2013) Sequestration and scavenging of iron in infection. Infect Immun 81(10):3503–3514PubMedCentralPubMed

Akerstrom B, Flower DR, Salier JP (2000) Lipocalins: unity in diversity. Biochim Biophys Acta 1482(1–2):1–8PubMed

Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268(14):10425–10432PubMed

Yan L, Borregaard N, Kjeldsen L, Moses MA (2001) The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 276(40):37258–37265PubMed

Xu SY, Carlson M, Engström A, Garcia R, Peterson CG, Venge P (1994) Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils. Scand J Clin Lab Invest 54(5):365–376PubMed

Kjeldsen L, Bainton DF, Sengeløv H, Borregaard N (1994) Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 83(3):799–807PubMed

Liu M, Prisco M, Drakas R, Searles D, Baserga R (2005) 24p3 in differentiation of myeloid cells. J Cell Physiol 205(2):302–309PubMed

Cowland JB, Borregaard N (1997) Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45(1):17–23PubMed

10.

Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J et al (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14(10):2534–2543PubMed

11.

Yoo do Y, Ko SH, Jung J, Kim YJ, Kim JS, Kim JM (2013) Bacteroides fragilis enterotoxin upregulates lipocalin-2 expression in intestinal epithelial cells. Lab Invest 93(4):384–396PubMed

12.

Alpízar-Alpízar W, Laerum OD, Illemann M, Ramírez JA, Arias A, Malespín-Bendaña W et al (2009) Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori. Virchows Arch 455(3):225–233PubMed

13.

Xu MJ, Feng D, Wu H, Wang H, Chan Y, Kolls J et al (2015) Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology 61(2):692–702PubMed

14.

Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK et al (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432(7019):917–921PubMed

15.

Berger T, Togawa A, Duncan GS, Elia AJ, You-Ten A, Wakeham A et al (2006) Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci USA 103(6):1834–1839PubMedCentralPubMed

16.

Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK (2002) The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 10(5):1033–1043PubMed

17.

Miethke M, Skerra A (2010) Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with l-norepinephrine-mediated bacterial iron acquisition. Antimicrob Agents Chemother 54(4):1580–1589PubMedCentralPubMed

18.

Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N (2005) The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579(3):773–777PubMed

19.

Devireddy LR, Gazin C, Zhu X, Green MR (2005) A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123(7):1293–1305PubMed

20.

Liu Z, Petersen R, Devireddy L (2013) Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections. J Immunol 190(9):4692–4706PubMedCentralPubMed

21.

Schroll A, Eller K, Feistritzer C, Nairz M, Sonnweber T, Moser PA et al (2012) Lipocalin-2 ameliorates granulocyte functionality. Eur J Immunol 42(12):3346–3357PubMed

22.

La Manna G, Ghinatti G, Tazzari PL, Alviano F, Ricci F, Capelli I et al (2014) Neutrophil gelatinase-associated lipocalin increases HLA-G(+)/FoxP3(+) T-regulatory cell population in an in vitro model of PBMC. PLoS One 9(2):e89497PubMedCentralPubMed

23.

Roudkenar MH, Halabian R, Bahmani P, Roushandeh AM, Kuwahara Y, Fukumoto M (2011) Neutrophil gelatinase-associated lipocalin: a new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. Free Radic Res 45(7):810–819PubMed

24.

Yang J, Mori K, Li JY, Barasch J (2003) Iron, lipocalin, and kidney epithelia. Am J Physiol Ren Physiol 285(1):F9–F18

25.

Cruz DN, Gaiao S, Maisel A, Ronco C, Devarajan P (2012) Neutrophil gelatinase-associated lipocalin as a biomarker of cardiovascular disease: a systematic review. Clin Chem Lab Med 50(9):1533–1545PubMedCentralPubMed

26.

Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A, NGAL Meta-analysis Investigator Group (2009) Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 54(6):1012–1024PubMed

27.

Peacock WF 4th, Maisel A, Kim J, Ronco C (2013) Neutrophil gelatinase associated lipocalin in acute kidney injury. Postgrad Med 125(6):82–93PubMed

28.

Mårtensson J, Bellomo R (2014) The rise and fall of NGAL in acute kidney injury. Blood Purif 37(4):304–310PubMed

29.

Bolignano D, Donato V, Lacquaniti A, Fazio MR, Bono C, Coppolino G et al (2010) Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett 288(1):10–16PubMed

30.

Kundu P, Ling TW, Korecka A, Li Y, D’Arienzo R, Bunte RM et al (2014) Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway. PLoS Pathog 10(1):e1003887PubMedCentralPubMed

31.

Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y (2005) Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion. FASEB J 19(13):1881–1883PubMed

32.

Miharada K, Hiroyama T, Sudo K, Danjo I, Nagasawa T, Nakamura Y (2008) Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells. J Cell Physiol 215(2):526–537PubMed

33.

Cowland JB, Sørensen OE, Sehested M, Borregaard N (2003) Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha. J Immunol 171(12):6630–6639PubMed

34.

Cowland JB, Muta T, Borregaard N (2006) IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. J Immunol 176(9):5559–5566PubMed

35.

Kohda A, Yamazaki S, Sumimoto H (2014) DNA element downstream of the κB site in the Lcn2 promoter is required for transcriptional activation by IκBζ and NF-κB p50. Genes Cells 19(8):620–628PubMed

36.

Karlsen JR, Borregaard N, Cowland JB (2010) Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta. J Biol Chem 285(19):14088–14100PubMedCentralPubMed

37.

Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA et al (2009) Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 5(5):476–486PubMedCentralPubMed

38.

Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ et al (2009) Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 206(2):299–311PubMedCentralPubMed

39.

Zhao P, Stephens JM (2013) STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes. Mol Metab 2(3):161–170PubMedCentralPubMed

40.

Marques F, Rodrigues AJ, Sousa JC, Coppola G, Geschwind DH, Sousa N et al (2008) Lipocalin 2 is a choroid plexus acute-phase protein. J Cereb Blood Flow Metab 28(3):450–455PubMed

41.

Ip JP, Noçon AL, Hofer MJ, Lim SL, Müller M, Campbell IL (2011) Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. J Neuroinflamm 26(8):124

42.

Jin M, Jang E, Suk K (2014) Lipocalin-2 acts as a neuroinflammatogen in lipopolysaccharide-injected mice. Exp Neurobiol 23(2):155–162PubMedCentralPubMed

43.

Jang E, Lee S, Kim JH, Kim JH, Seo JW, Lee WH et al (2013) Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J 27(3):1176–1190PubMed

44.

Lee S, Kim JH, Kim JH, Seo JW, Han HS, Lee WH et al (2011) Lipocalin-2 Is a chemokine inducer in the central nervous system: role of chemokine ligand 10 (CXCL10) in lipocalin-2-induced cell migration. J Biol Chem 286(51):43855–43870PubMedCentralPubMed

45.

Jang E, Kim JH, Lee S, Kim JH, Seo JW, Jin M et al (2013) Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes. J Immunol 191(10):5204–5219PubMed

46.

Guiddir T, Deghmane AE, Giorgini D, Taha MK (2014) Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis. BMC Infect Dis 20(14):276

47.

Lippi G, Avanzini P, Calzetti C, Caleffi A, Pipitone S, Musa R et al (2014) The role of neutrophil gelatinase-associated lipocalin (NGAL) in cerebrospinal fluids for screening of acute bacterial meningitis. Clin Lab 60(3):377–381PubMed

48.

Wu H, Santoni-Rugiu E, Ralfkiaer E, Porse BT, Moser C, Høiby N et al (2010) Lipocalin 2 is protective against E. coli pneumonia. Respir Res 15(11):96

49.

Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V et al (2012) Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax 67(6):533–539PubMedCentralPubMed

50.

Robinson KM, McHugh KJ, Mandalapu S, Clay ME, Lee B, Scheller EV et al (2014) Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production. J Infect Dis 209(6):865–875PubMedCentralPubMed

51.

Bellmann-Weiler R, Schroll A, Engl S, Nairz M, Talasz H, Seifert M et al (2013) Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis. Immunobiology 218(7):969–978PubMedCentralPubMed

52.

Bachman MA, Miller VL, Weiser JN (2009) Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin. PLoS Pathog 5(10):e1000622PubMedCentralPubMed

53.

Bachman MA, Oyler JE, Burns SH, Caza M, Lépine F, Dozois CM et al (2011) Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2. Infect Immun 79(8):3309–3316PubMedCentralPubMed

54.

Bachman MA, Lenio S, Schmidt L, Oyler JE, Weiser JN (2012) Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia. MBio 3(6). doi:10.1128/mBio.00224-11

55.

Peek ME, Bhatnagar A, McCarty NA, Zughaier SM (2012) Pyoverdine, the major siderophore in Pseudomonas aeruginosa, evades NGAL recognition. Interdiscip Perspect Infect Dis 2012:843509PubMedCentralPubMed

56.

Zughaier SM, Tangpricha V, Leong T, Stecenko AA, McCarty NA (2013) Peripheral monocytes derived from patients with cystic fibrosis and healthy donors secrete NGAL in response to Pseudomonas aeruginosa infection. J Investig Med 61(6):1018–1025PubMed

57.

Ratledge C (2004) Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb) 84(1–2):110–130

58.

Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK (2005) Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure 13(1):29–41PubMed

59.

Hoette TM, Clifton MC, Zawadzka AM, Holmes MA, Strong RK, Raymond KN (2011) Immune interference in Mycobacterium tuberculosis intracellular iron acquisition through siderocalin recognition of carboxymycobactins. ACS Chem Biol 6(12):1327–1331PubMedCentralPubMed

60.

Halaas O, Steigedal M, Haug M, Awuh JA, Ryan L, Brech A et al (2010) Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway. J Infect Dis 201(5):783–792PubMedCentralPubMed

61.

Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebicka E, Wang L et al (2010) Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages. FEMS Immunol Med Microbiol 58(1):138–145PubMedCentralPubMed

62.

Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S et al (2008) Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. J Immunol 181(12):8521–8527PubMed

63.

Guglani L, Gopal R, Rangel-Moreno J, Junecko BF, Lin Y, Berger T et al (2012) Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections. PLoS One 7(11):e50052PubMedCentralPubMed

64.

Yeh YH, Chang JL, Hsiao PC, Tsao SM, Lin CH, Kao SJ et al (2013) Circulating level of lipocalin 2 as a predictor of severity in patients with community-acquired pneumonia. J Clin Lab Anal 27(4):253–260PubMed

65.

Axelsson L, Bergenfeldt M, Ohlsson K (1995) Studies of the release and turnover of a human neutrophil lipocalin. Scand J Clin Lab Invest 55(7):577–588PubMed

66.

Leung JC, Lam MF, Tang SC, Chan LY, Tam KY, Yip TP et al (2009) Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis. J Clin Immunol 29(3):365–378PubMed

67.

Martino FK, Filippi I, Giavarina D, Kaushik M, Rodighiero MP, Crepaldi C et al (2012) Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of neutrophil gelatinase-associated lipocalin. Contrib Nephrol 178:258–263PubMed

68.

Lippi G, Caleffi A, Pipitone S, Elia G, Ngah A, Aloe R et al (2013) Assessment of neutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis. Clin Chim Acta 15(418):59–62

69.

Decavele AS, Dhondt L, De Buyzere ML, Delanghe JR (2011) Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia. Clin Chem Lab Med 49(6):999–1003PubMed

70.

Paragas N, Kulkarni R, Werth M, Schmidt-Ott KM, Forster C, Deng R et al (2014) α-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest 124(7):2963–2976PubMedCentralPubMed

71.

Lee SJ, Borsting E, Declèves AE, Singh P, Cunard R (2012) Podocytes express IL-6 and lipocalin 2/neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury. Nephron Exp Nephrol 121(3–4):e86–e96PubMedCentralPubMed

72.

Ichino M, Kuroyanagi Y, Kusaka M, Mori T, Ishikawa K, Shiroki R et al (2009) Increased urinary neutrophil gelatinase associated lipocalin levels in a rat model of upper urinary tract infection. J Urol 181(5):2326–2331PubMed

73.

Urbschat A, Obermüller N, Paulus P, Reissig M, Hadji P, Hofmann R et al (2014) Upper and lower urinary tract infections can be detected early but not be discriminated by urinary NGAL in adults. Int Urol Nephrol 46(12):2243–2249PubMed

74.

Yilmaz A, Sevketoglu E, Gedikbasi A, Karyagar S, Kiyak A, Mulazimoglu M et al (2009) Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol 24(12):2387–2392PubMed

75.

Hatipoglu S, Sevketoglu E, Gedikbasi A, Yilmaz A, Kiyak A, Mulazimoglu M et al (2011) Urinary MMP-9/NGAL complex in children with acute cystitis. Pediatr Nephrol 26(8):1263–1268PubMed

76.

Lee HE, Kim DK, Kang HK, Park K (2015) The diagnosis of febrile urinary tract infection in children may be facilitated by urinary biomarkers. Pediatr Nephrol 30(1):123–130PubMed

77.

Seo WH, Nam SW, Lee EH, Je BK, Yim HE, Choi BM (2014) A rapid plasma neutrophil gelatinase-associated lipocalin assay for diagnosis of acute pyelonephritis in infants with acute febrile urinary tract infections: a preliminary study. Eur J Pediatr 173(2):229–232PubMed

78.

Kim BH, Yu N, Kim HR, Yun KW, Lim IS, Kim TH et al (2014) Evaluation of the optimal neutrophil gelatinase-associated lipocalin value as a screening biomarker for urinary tract infections in children. Ann Lab Med 34(5):354–359PubMedCentralPubMed

79.

Kienzl-Wagner K, Moschen AR, Geiger S, Bichler A, Aigner F, Brandacher G et al (2014) The role of lipocalin-2 in liver regeneration. Liver Int. doi:10.1111/liv.12634 PubMed

80.

Borkham-Kamphorst E, van de Leur E, Zimmermann HW, Karlmark KR, Tihaa L, Haas U et al (2013) Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis. Biochim Biophys Acta 1832(5):660–673PubMed

81.

Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, Shashidharamurthy R et al (2012) Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol 189(4):1911–1919PubMedCentralPubMed

82.

Sunil VR, Patel KJ, Nilsen-Hamilton M, Heck DE, Laskin JD, Laskin DL (2007) Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol 83(2):177–187PubMedCentralPubMed

83.

Lentini P, de Cal M, Clementi A, D’Angelo A, Ronco C (2012) Sepsis and AKI in ICU patients: the role of plasma biomarkers. Crit Care Res Pract 2012:856401PubMedCentralPubMed

84.

Hur M, Kim H, Lee S, Cristofano F, Magrini L, Marino R et al (2014) Diagnostic and prognostic utilities of multimarkers approach using procalcitonin, B-type natriuretic peptide, and neutrophil gelatinase-associated lipocalin in critically ill patients with suspected sepsis. BMC Infect Dis 24(14):224

85.

Smertka M, Wroblewska J, Suchojad A, Majcherczyk M, Jadamus-Niebroj D, Owsianka-Podlesny T et al (2014) Serum and urinary NGAL in septic newborns. Biomed Res Int 2014:717318PubMedCentralPubMed

86.

Mårtensson J, Bell M, Xu S, Bottai M, Ravn B, Venge P et al (2013) Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction. Biomarkers 18(4):349–356PubMed

87.

Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R et al (2014) Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock 42(2):99–107PubMed

88.

Bagshaw SM, Bennett M, Haase M, Haase-Fielitz A, Egi M, Morimatsu H et al (2010) Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 36(3):452–461PubMed

89.

Zarbock A, Gomez H, Kellum JA (2014) Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies. Curr Opin Crit Care 20(6):588–595PubMed

90.

Ferreira MC, Whibley N, Mamo AJ, Siebenlist U, Chan YR, Gaffen SL (2014) Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis. Infect Immun 82(3):1030–1035PubMedCentralPubMed

91.

Caza M, Kronstad JW (2013) Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans. Front Cell Infect Microbiol 19(3):80

92.

Beghini J, Giraldo PC, Linhares IM, Ledger WJ, Witkin SS (2015) Neutrophil gelatinase-associated lipocalin concentration in vaginal fluid: relation to bacterial vaginosis and vulvovaginal candidiasis. Reprod Sci (in press)

93.

Tsai HT, Su PH, Lee TH, Tee YT, Lin LY, Yang SF et al (2011) Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease. Clin Chim Acta 412(13–14):1252–1256PubMed

94.

Tee YT, Wang PH, Yang SF, Tsai HT, Lee SK, Ko JL et al (2014) Correlation of plasma osteopontin and neutrophil gelatinase-associated lipocalin levels with the severity and clinical outcome of pelvic inflammatory disease. Taiwan J Obstet Gynecol 53(2):158–161PubMed

95.

Tadesse S, Luo G, Park JS, Kim BJ, Snegovskikh VV, Zheng T et al (2011) Intra-amniotic infection upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the maternal–fetal interface at term: implications for infection-related preterm birth. Reprod Sci 18:713–722PubMedCentralPubMed

96.

D’Anna R, Baviera G, Giordano D et al (2010) Neutrophil gelatinase-associated lipocalin serum evaluation through normal pregnancy and in pregnancies complicated by preeclampsia. Acta Obstet Gynecol Scand 89:275–278PubMed

97.

D’Anna R, Baviera G, Corrado F, Giordano D, Recupero S, Di Benedetto A (2009) First trimester serum neutrophil gelatinase-associated lipocalin in gestational diabetes. Diabet Med 26:1293–1295PubMed

98.

Xu SY, Pauksen K, Venge P (1995) Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections. Scand J Clin Lab Invest 55(2):125–131PubMed

99.

Noçon AL, Ip JP, Terry R, Lim SL, Getts DR, Müller M et al (2014) The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. J Virol 88(1):679–689PubMedCentralPubMed

100.

Hraba-Renevey S, Türler H, Kress M, Salomon C, Weil R (1989) SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene 4(5):601–608PubMed

101.

Vijay-Kumar M, Gentsch JR, Kaiser WJ, Borregaard N, Offermann MK, Neish AS et al (2005) Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. J Immunol 174(10):6322–6331PubMed

102.

Syrjänen S, Naud P, Sarian L, Derchain S, Roteli-Martins C, Tatti S et al (2010) Up-regulation of lipocalin 2 is associated with high-risk human papillomavirus and grade of cervical lesion at baseline but does not predict outcomes of infections or incident cervical intraepithelial neoplasia. Am J Clin Pathol 134(1):50–59PubMed

103.

Akgül B, Bauer B, Zigrino P, Storey A, Mauch C, Pfister H (2011) Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas. J Gen Virol 92(Pt 2):395–401PubMed

104.

Landrø L, Damås JK, Flo TH, Heggelund L, Ueland T, Tjønnfjord GE et al (2008) Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy. Clin Exp Immunol 152(1):57–63PubMedCentralPubMed

105.

Sola-Del Valle DA, Mohan S, Cheng JT, Paragas NA, Sise ME, D’Agati VD et al (2011) Urinary NGAL is a useful clinical biomarker of HIV-associated nephropathy. Nephrol Dial Transpl 26(7):2387–2390

106.

Nelson AL, Barasch JM, Bunte RM, Weiser JN (2005) Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity. Cell Microbiol 7(10):1404–1417PubMed

107.

Abergel RJ, Wilson MK, Arceneaux JE, Hoette TM, Strong RK, Byers BR et al (2006) Anthrax pathogen evades the mammalian immune system through stealth siderophore production. Proc Natl Acad Sci USA 103(49):18499–18503PubMedCentralPubMed

108.

Allred BE, Correnti C, Clifton MC, Strong RK, Raymond KN (2013) Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae. ACS Chem Biol 8(9):1882–1887PubMedCentralPubMed

109.

Fischbach MA, Lin H, Liu DR, Walsh CT (2005) In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc Natl Acad Sci USA 102(3):571–576PubMedCentralPubMed

110.

Abergel RJ, Moore EG, Strong RK, Raymond KN (2006) Microbial evasion of the immune system: structural modifications of enterobactin impair siderocalin recognition. J Am Chem Soc 128(34):10998–10999PubMedCentralPubMed

111.

Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR et al (2006) The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci USA 103(44):16502–16507PubMedCentralPubMed

Titel: Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections
verfasst von: Dimitrios Nasioudis
Steven S. Witkin
Publikationsdatum: 01.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical Microbiology and Immunology / Ausgabe 4/2015
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-015-0394-1

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Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren.

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

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