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Journal of Cancer Research and Clinical Oncology

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01.12.2006 | Original Paper

ΔNp63 protein expression in uterine cervical and endometrial cancers

verfasst von: Zhenhua Lin, Mingzhu Liu, Zhuhu Li, Changheon Kim, Eungseok Lee, Insun Kim

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 12/2006

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Abstract

Purpose

To investigate the significance of p63 expression in uterine cervical and endometrial cancers.

Materials and methods

ΔNp63 protein expression was studied in a variety of 127 cases of uterine cervical lesions (20 non-neoplastic cervices, 43 cervical intraepithelial neoplasia [CIN], 54 squamous cell carcinomas (SCCs), 40 adenocarcinomas, and 13 other histologic types) and 30 endometrioid type of endometrial adenocarcinomas by using immunohistochemistry. One SCC cell line (ME-180) and one adenocarcinoma cell line (HeLa) were also included.

Results

In uterine cervix, the expression of ΔNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas. Adenosquamous cell carcinoma and mixed neuroendocrine and squamous cell carcinoma were positive in squamous component, but not in adenocarcinoma and neuroendocrine carcinoma components. ME-180 cell line was positive, whereas HeLa cell line was negative. Endometrioid type of endometrial adenocarcinomas showed a positive staining in glandular (26.7%) and squamous component.

Conclusions

Immunohistochemical staining for ΔNp63 is a powerful marker for squamous differentiation and useful in exclusion of glandular and neuroendocrine differentiation in uterine cervical cancers, but not always in endometrial cancers.

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Titel: ΔNp63 protein expression in uterine cervical and endometrial cancers
verfasst von: Zhenhua Lin
Mingzhu Liu
Zhuhu Li
Changheon Kim
Eungseok Lee
Insun Kim
Publikationsdatum: 01.12.2006
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 12/2006
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-006-0130-8

Springer Medizin

ΔNp63 protein expression in uterine cervical and endometrial cancers

Abstract

Purpose

Materials and methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Materials and methods

Results

Conclusions

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