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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.08.2013 | Original Paper

Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population

verfasst von: Meili Lv, Wei Dong, Lijuan Li, Lushun Zhang, Xiaowei Su, Li Wang, Linbo Gao, Lin Zhang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2013

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Abstract

Introduction

Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA expression levels or processing and then contribute to the susceptibility of cancer development. We hypothesized that SNPs in pre-miRNAs may be associated with the risk of colorectal cancer (CRC).

Materials and methods

We genotyped four common polymorphisms (i.e., rs11614913, rs3746444, rs2910164, and rs2292832) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between the SNPs and the risk of CRC using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) assay.

Results

The rs11614913 CT, TT genotypes, and T allele were associated with an increased risk of CRC compared with the CC genotype and C allele (CT vs. CC: OR = 7.34, 95 % CI 3.76–14.34; TT vs. CC: OR = 13.66, 95 % CI 6.76–27.6; T vs. C: OR = 1.99, 95 % CI 1.63–2.42, respectively). Interestingly, using the rs2910164 GG genotype as a reference, the rs2910164 GC genotype was associated with an increased risk of CRC (OR = 1.49, 95 % CI 1.02–2.18), whereas the rs2910164 CC genotype was associated with a decreased risk of CRC (OR = 0.58, 95 % CI 0.37–0.93). When compared with the rs2910164G allele, rs2910164 C allele was associated with a reduced risk of CRC (OR = 0.80, 95 % CI 0.66–0.97, p = 0.02).

Conclusion

These findings suggest that rs11614913 and rs2910164 polymorphisms may be associated with the etiology of CRC.

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Titel: Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population
verfasst von: Meili Lv
Wei Dong
Lijuan Li
Lushun Zhang
Xiaowei Su
Li Wang
Linbo Gao
Lin Zhang
Publikationsdatum: 01.08.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2013
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-013-1456-7

Springer Medizin

Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population

Abstract

Introduction

Materials and methods

Results

Conclusion

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Introduction

Materials and methods

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Conclusion

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