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Journal of Cancer Research and Clinical Oncology

Erschienen in:

19.08.2015 | Review – Cancer Research

Membrane microparticles: shedding new light into cancer cell communication

verfasst von: Paloma Silva de Souza, Roberta Soares Faccion, Paula Sabbo Bernardo, Raquel Ciuvalschi Maia

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 7/2016

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Abstract

Background

Microparticles (MPs) or ectosomes are small enclosed fragments (from 0.2 to 2 μm in diameter) released from the cellular plasma membrane. Several oncogenic molecules have been identified inside MPs, including soluble proteins XIAP, survivin, metalloproteinases, CX3CL1, PYK2 and other microRNA-related proteins; membrane proteins EGFR, HER-2, integrins and efflux pumps; and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others. Studies have shown that MPs transfer their cargo to neoplastic or non-malignant cells and thus contribute to activation of oncogenic pathways, resulting in cell survival, drug resistance and cancer dissemination.

Discussion and Conclusion

This review summarizes recent findings on MP biogenesis and the role of the MPs cargo in cancer and discusses some of the RNAs and proteins involved. In addition, the discussion covers evidence of (1) how and which signaling pathways can be activated by MPs in recipient cells; (2) recipient cell-type selectivity in incorporation of proteins and RNAs transported by MPs; and (3) how upon stimulation, stromal cells release MPs, promoting resistance to chemotherapeutics and invasiveness in cancer cells.

Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, Rak J (2008) Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10(5):619–624PubMedCrossRef

Al-Nedawi K, Meehan B, Kerbel RS, Allison AC, Rak J (2009) Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci USA 106(10):3794–3799PubMedPubMedCentralCrossRef

Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ (2011) Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29(4):341–345PubMedCrossRef

Antonyak MA et al (2011) Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc Natl Acad Sci USA 108(12):4852–4857PubMedPubMedCentralCrossRef

Arpin M, Chirivino D, Naba A, Zwaenepoel I (2011) Emerging role for ERM proteins in cell adhesion and migration. Cell Adhes Migr 5(2):199–206CrossRef

Arroyo JD et al (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 108(12):5003–5008PubMedPubMedCentralCrossRef

Baj-Krzyworzeka M, Szatanek R, Weglarczyk K, Baran J, Zembala M (2007) Tumour-derived microvesicles modulate biological activity of human monocytes. Immunol Lett 113(2):76–82PubMedCrossRef

Bazan JF et al (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385(6617):640–644PubMedCrossRef

Bebawy M, Combes V, Lee E, Jaiswal R, Gong J, Bonhoure A, Grau GE (2009) Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia 23(9):1643–1649PubMedCrossRef

Bellahcene A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS (2008) Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer 8(3):212–226PubMedPubMedCentralCrossRef

Brambilla D et al (2012) P-glycoprotein binds to ezrin at amino acid residues 149–242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. Int J Cancer 130(12):2824–2834PubMedCrossRef

Castellana D, Zobairi F, Martinez MC, Panaro MA, Mitolo V, Freyssinet JM, Kunzelmann C (2009) Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1–CX3CR1 axis. Cancer Res 69(3):785–793PubMedCrossRef

Chen P, Douglas SD, Meshki J, Tuluc F (2012) Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells. PLoS ONE 7(9):e45322PubMedPubMedCentralCrossRef

Constantinescu P, Wang B, Kovacevic K, Jalilian I, Bosman GJ, Wiley JS, Sluyter R (2010) P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells. Biochim Biophys Acta 1798(9):1797–1804PubMedCrossRef

Datta A et al (2015) Selective targeting of FAK-Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells. Cancer Lett 362(1):25–35PubMedCrossRef

de Souza PS, Cruz AL, Viola JP, Maia RC (2015) Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type. Cancer Sci 106(1):60–68PubMedCrossRef

Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA (2005) Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 106(5):1604–1611PubMedCrossRef

Donatello S, Babina IS, Hazelwood LD, Hill AD, Nabi IR, Hopkins AM (2012) Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration. Am J Pathol 181(6):2172–2187PubMedPubMedCentralCrossRef

D’Souza-Schorey C, Chavrier P (2006) ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol 7(5):347–358PubMedCrossRef

El Andaloussi S, Mager I, Breakefield XO, Wood MJ (2013) Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 12(5):347–357CrossRef

Enjeti AK, Lincz LF, Seldon M (2008) Microparticles in health and disease. Semin Thromb Hemost 34(7):683–691PubMedCrossRef

Faccion RS, Rezende LM, Romano Sde O, Bigni Rde S, Mendes GL, Maia RC (2012) Centroblastic diffuse large B cell lymphoma displays distinct expression pattern and prognostic role of apoptosis resistance related proteins. Cancer Invest 30(5):404–414PubMedCrossRef

Fadok VA, Bratton DL, Frasch SC, Warner ML, Henson PM (1998) The role of phosphatidylserine in recognition of apoptotic cells by phagocytes. Cell Death Differ 5(7):551–562PubMedCrossRef

Fan H, Guan JL (2011) Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. J Biol Chem 286(21):18573–18582PubMedPubMedCentralCrossRef

Feng DD et al (2011) Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. J Cell Mol Med 15(10):2164–2175PubMedPubMedCentralCrossRef

Fleitas T et al (2012) Circulating endothelial cells and microparticles as prognostic markers in advanced non-small cell lung cancer. PLoS ONE 7(10):e47365PubMedPubMedCentralCrossRef

Fremder E et al (2014) Tumor-derived microparticles induce bone marrow-derived cell mobilization and tumor homing: a process regulated by osteopontin. Int J Cancer 135(2):270–281PubMedCrossRef

Fujiwara T, Kunisada T, Takeda K, Uotani K, Yoshida A, Ochiya T, Ozaki T (2014) MicroRNAs in soft tissue sarcomas: overview of the accumulating evidence and importance as novel biomarkers. BioMed Res Int. Article ID 592868

Fulda S, Vucic D (2012) Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 11(2):109–124PubMedCrossRef

Gan HK, Cvrljevic AN, Johns TG (2013) The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J 280(21):5350–5370PubMedCrossRef

Geng W et al (2011) The role of proline rich tyrosine kinase 2 (Pyk2) on cisplatin resistance in hepatocellular carcinoma. PLoS ONE 6(11):e27362PubMedPubMedCentralCrossRef

Gimba ER, Tilli TM (2013) Human osteopontin splicing isoforms: known roles, potential clinical applications and activated signaling pathways. Cancer Lett 331(1):11–17PubMedCrossRef

Gong J, Luk F, Jaiswal R, Bebawy M (2014) Microparticles mediate the intercellular regulation of microRNA-503 and proline-rich tyrosine kinase 2 to alter the migration and invasion capacity of breast cancer cells. Front Oncol 4:220PubMedPubMedCentral

Gong J, Jaiswal R, Dalla P, Luk F, Bebawy M (2015) Microparticles in cancer: a review of recent developments and the potential for clinical application. Semin Cell Dev Biol 40: 35–40PubMedCrossRef

Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2(1):48–58PubMedCrossRef

Hoffmann PR et al (2001) Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells. J Cell Biol 155(4):649–659PubMedPubMedCentralCrossRef

Honegger A, Leitz J, Bulkescher J, Hoppe-Seyler K, Hoppe-Seyler F (2013) Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells. Int J Cancer 133(7):1631–1642PubMedCrossRef

Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM (2005) Membrane microparticles: two sides of the coin. Physiology 20:22–27PubMedCrossRef

Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K (2010) STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 39(4):493–506PubMedPubMedCentralCrossRef

Inns J, James V (2015) Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease. Breast 24(4):364–369PubMedCrossRef

Iqbal N, Iqbal N (2014) Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications. Mol Biol Int 2014:852748PubMedPubMedCentralCrossRef

Jackson BL, Grabowska A, Ratan HL (2014) MicroRNA in prostate cancer: functional importance and potential as circulating biomarkers. BMC Cancer 14:930PubMedPubMedCentralCrossRef

Jaiswal R et al (2012a) Microparticle-associated nucleic acids mediate trait dominance in cancer. FASEB J 26(1):420–429PubMedCrossRef

Jaiswal R, Luk F, Gong J, Mathys JM, Grau GE, Bebawy M (2012b) Microparticle conferred microRNA profiles–implications in the transfer and dominance of cancer traits. Mol Cancer 11:37PubMedPubMedCentralCrossRef

Jaiswal R, Luk F, Dalla PV, Grau GE, Bebawy M (2013) Breast cancer-derived microparticles display tissue selectivity in the transfer of resistance proteins to cells. PLoS ONE 8(4):e61515PubMedPubMedCentralCrossRef

Jansson MD, Lund AH (2012) MicroRNA and cancer. Mol Oncol 6(6):590–610PubMedCrossRef

Ji H, Chen M, Greening DW, He W, Rai A, Zhang W, Simpson RJ (2014) Deep sequencing of RNA from three different extracellular vesicle (EV) subtypes released from the human LIM1863 colon cancer cell line uncovers distinct miRNA-enrichment signatures. PLoS ONE 9(10):e110314PubMedPubMedCentralCrossRef

Jouvenet N (2012) Dynamics of ESCRT proteins. Cell Mol Life Sci 69(24):4121–4133PubMedCrossRef

Juarez J, Bendall L (2004) SDF-1 and CXCR4 in normal and malignant hematopoiesis. Histol Histopathol 19(1):299–309PubMed

Jutten B, Rouschop KM (2014) EGFR signaling and autophagy dependence for growth, survival, and therapy resistance. Cell Cycle 13(1):42–51PubMedCrossRef

Kahn J et al (2004) Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood 103(8):2942–2949PubMedCrossRef

Kalinkovich A et al (2006) Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells. Cancer Res 66(22):11013–11020PubMedCrossRef

Lam D, Barre B, Guette C, Coqueret O (2013) Circulating miRNAs as new activators of the JAK-STAT3 pathway. JAK-STAT 2(1):e22996PubMedPubMedCentralCrossRef

Lapidot T, Dar A, Kollet O (2005) How do stem cells find their way home? Blood 106(6):1901–1910PubMedCrossRef

Li L et al (2012) Argonaute 2 complexes selectively protect the circulating microRNAs in cell-secreted microvesicles. PLoS ONE 7(10):e46957PubMedPubMedCentralCrossRef

Liang Z et al (2010) Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol 79(6):817–824PubMedCrossRef

Liebhardt S et al (2010) CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients. Anticancer Res 30(5):1707–1712PubMed

Lindner K, Haier J, Wang Z, Watson DI, Hussey DJ, Hummel R (2015) Circulating microRNAs: emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers. Clin Sci 128(1):1–15PubMedCrossRef

Liu HS, Xiao HS (2014) MicroRNAs as potential biomarkers for gastric cancer. World J Gastroenterol 20(34):12007–12017PubMedPubMedCentralCrossRef

Lorand L, Graham RM (2003) Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 4(2):140–156PubMedCrossRef

Lozito TP, Tuan RS (2014) Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors. J Cell Mol Med 18(12):2372–2384PubMedPubMedCentralCrossRef

Lu JF, Luk F, Gong J, Jaiswal R, Grau GE, Bebawy M (2013) Microparticles mediate MRP1 intercellular transfer and the re-templating of intrinsic resistance pathways. Pharmacol Res 76:77–83PubMedCrossRef

Luciani F et al (2002) P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin. Blood 99(2):641–648PubMedCrossRef

Ma J et al (2013) Innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin alpha(M)beta(2) to tumor cells. J Immunol 191(6):3453–3461PubMedCrossRef

Mause SF, Weber C (2010) Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 107(9):1047–1057PubMedCrossRef

McCullough J, Colf LA, Sundquist WI (2013) Membrane fission reactions of the mammalian ESCRT pathway. Ann Rev Biochem 82:663–692PubMedPubMedCentralCrossRef

Meshki J, Douglas SD, Lai JP, Schwartz L, Kilpatrick LE, Tuluc F (2009) Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism. J Biol Chem 284(14):9280–9289PubMedPubMedCentralCrossRef

Miletti-Gonzalez KE et al (2005) The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res 65(15):6660–6667PubMedCrossRef

Mitroulis I, Alexaki VI, Kourtzelis I, Ziogas A, Hajishengallis G, Chavakis T (2015) Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacol Ther 147:123–135PubMedCrossRef

Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, Nagata S (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450(7168):435–439PubMedCrossRef

Muralidharan-Chari V, Clancy J, Plou C, Romao M, Chavrier P, Raposo G, D’Souza-Schorey C (2009) ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr Biol 19(22):1875–1885PubMedPubMedCentralCrossRef

Park D et al (2007) BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450(7168):430–434PubMedCrossRef

Pasquier J et al (2014) Microparticles mediated cross-talk between tumoral and endothelial cells promote the constitution of a pro-metastatic vascular niche through Arf6 up regulation. Cancer Microenviron 7(1–2):41–59PubMedPubMedCentralCrossRef

Piccin A, Murphy WG, Smith OP (2007) Circulating microparticles: pathophysiology and clinical implications. Blood Rev 21(3):157–171PubMedCrossRef

Pimentel F et al. (2014) Technology in MicroRNA Profiling: Circulating MicroRNAs as Noninvasive Cancer Biomarkers in Breast Cancer. J Lab Autom [Epub ahead of print]

Pokharel D, Padula MP, Lu JF, Tacchi JL, Luk F, Djordjevic SP, Bebawy M (2014) Proteome analysis of multidrug-resistant, breast cancer-derived microparticles. J Extracell Vesicles. doi:10.3402/jev.v3.24384

Qu Y, Dubyak GR (2009) P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways. Purinergic Signal 5(2):163–173PubMedPubMedCentralCrossRef

Qu Y, Franchi L, Nunez G, Dubyak GR (2007) Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol 179(3):1913–1925PubMedCrossRef

Ramchandani D, Weber GF (2015) Interactions between osteopontin and vascular endothelial growth factor: implications for cancer. Biochim Biophys Acta 1855(2):202–222PubMed

Roger S, Jelassi B, Couillin I, Pelegrin P, Besson P, Jiang L (2014) Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives. Biochimica et Biophysica Acta. doi:10.1016/j.bbamem.2014.10.029

Salzer U, Hinterdorfer P, Hunger U, Borken C, Prohaska R (2002) Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin. Blood 99(7):2569–2577PubMedCrossRef

Savasan S, Buyukavci M, Buck S, Ravindranath Y (2004) Leukaemia/lymphoma cell microparticles in childhood mature B cell neoplasms. J Clin Pathol 57(6):651–653PubMedPubMedCentralCrossRef

Schlienger S, Campbell S, Claing A (2014) ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion. Mol Biol Cell 25(1):17–29PubMedPubMedCentralCrossRef

Simak J, Holada K, Risitano AM, Zivny JH, Young NS, Vostal JG (2004) Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria. Br J Haematol 125(6):804–813PubMedCrossRef

Toth B et al (2008) Circulating microparticles in breast cancer patients: a comparative analysis with established biomarkers. Anticancer Res 28(2A):1107–1112PubMed

Turchinovich A, Weiz L, Langheinz A, Burwinkel B (2011) Characterization of extracellular circulating microRNA. Nucleic Acids Res 39(16):7223–7233PubMedPubMedCentralCrossRef

Ujhazy P, Berleth ES, Pietkiewicz JM, Kitano H, Skaar JR, Ehrke MJ, Mihich E (1996) Evidence for the involvement of ecto-5’-nucleotidase (CD73) in drug resistance. Int J Cancer 68(4):493–500PubMedCrossRef

van den Akker J et al (2012) Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation. Amino Acids 42(2–3):961–973PubMedCrossRef

Vasconcelos FC, Silva KL, Souza PS, Silva LF, Moellmann-Coelho A, Klumb CE, Maia RC (2011) Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients. Cytom Part B Clin Cytom 80(3):158–166CrossRef

Verhagen AM, Coulson EJ, Vaux DL (2001) Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol 2(7):3009CrossRef

Wang L et al (2008) Ecto-5’-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells. J Cancer Res Clin Oncol 134(3):365–372PubMedCrossRef

Wang L et al (2013) Ecto-5’-nucleotidase (CD73) promotes tumor angiogenesis. Clin Exp Metastasis 30(5):671–680PubMedCrossRef

Winter J, Jung S, Keller S, Gregory RI, Diederichs S (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11(3):228–234PubMedCrossRef

Wysoczynski M, Ratajczak MZ (2009) Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors. Int J Cancer 125(7):1595–1603PubMedPubMedCentralCrossRef

Yang Y et al (2014) MiR-503 targets PI3K p85 and IKK-beta and suppresses progression of non-small cell lung cancer. Int J Cancer 135(7):1531–1542PubMedCrossRef

Zhi X, Chen S, Zhou P, Shao Z, Wang L, Ou Z, Yin L (2007) RNA interference of ecto-5’-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion. Clin Exp Metastasis 24(6):439–448PubMedCrossRef

Zhou J, Wang W (2011) Analysis of microRNA expression profiling identifies microRNA-503 regulates metastatic function in hepatocellular cancer cell. J Surg Oncol 104(3):278–283PubMedCrossRef

Zhou R, Gong AY, Chen D, Miller RE, Eischeid AN, Chen XM (2013) Histone deacetylases and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503. PLoS ONE 8(5):e65153PubMedPubMedCentralCrossRef

Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM (2008) Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol 76(5):582–588PubMedPubMedCentralCrossRef

Zhuang X et al (2011) Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther 19(10):1769–1779PubMedPubMedCentralCrossRef

Zlotnik A (2004) Chemokines in neoplastic progression. Semin Cancer Biol 14(3):181–185PubMedCrossRef

Titel: Membrane microparticles: shedding new light into cancer cell communication
verfasst von: Paloma Silva de Souza
Roberta Soares Faccion
Paula Sabbo Bernardo
Raquel Ciuvalschi Maia
Publikationsdatum: 19.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 7/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-015-2029-8

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Membrane microparticles: shedding new light into cancer cell communication

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