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Journal of Cancer Research and Clinical Oncology

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20.08.2018 | Review – Cancer Research

The heat shock protein 47 as a potential biomarker and a therapeutic agent in cancer research

verfasst von: Beatriz Dal Pont Duarte, Diego Bonatto

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 12/2018

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Abstract

Heat shock protein 47 (HSP47) is an important chaperone required for the correct folding and secretion of collagen. Several studies revealed that HSP47 has a role in numerous steps of collagen synthesis, preventing procollagen aggregation and inducing hydroxylation of proline and lysine residues. HSP47 is encoded by the SERPINH1 gene, which is located on chromosome 11q13.5, one of the most frequently amplified regions in human cancer. The altered expression levels of HSP47 have been correlated with several types of cancer, such as cervical, breast, pancreatic and gastric cancers. Studies have shown that HSP47 promotes tumor angiogenesis, growth, migration and metastatic capacity. In this review, we highlight the fundamental aspects of the interaction between HSP47 and collagen and the recent discoveries of the role of this chaperone in different types of malignant neoplasias. We also discuss recent treatments using HSP47 as a therapeutic target, and present evidences that HSP47 is an essential protein for cancer biology and a potential molecular target for chemotherapy.

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Titel: The heat shock protein 47 as a potential biomarker and a therapeutic agent in cancer research
verfasst von: Beatriz Dal Pont Duarte
Diego Bonatto
Publikationsdatum: 20.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 12/2018
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-018-2739-9

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