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Erschienen in:

01.06.2013 | Original Article

Renal impairment in children with posterior urethral valves

verfasst von: Jameela Abdulaziz Kari, Sherif El-Desoky, Youssef Farag, Hisham Mosli, Abdul-Malik Altyieb, Ahmad Al Sayad, Othman Radawi, Hosam Ghabra, Faten Basnawi, Ohood Bahrawi, Ajay Singh, Hassan Farsi

Erschienen in: Pediatric Nephrology | Ausgabe 6/2013

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Abstract

Background

Posterior urethral valves (PUV) are a common cause of end-stage renal failure in childhood. Our aim was to describe a cohort of patients with PUV and to investigate the predictors of renal impairment.

Methods

We performed a retrospective chart review of children with PUV who were followed at King Abdulaziz University hospital between 2002 and 2011.

Results

The cohort comprised 68 boys. There was a significant difference in the duration of follow-up (p = 0.024), nadir serum creatinine (p < 0.001), and last known serum creatinine level (p = 0.001) between the patients with and without renal impairment. The duration of follow-up appeared to be a significant predictor for serum creatinine doubling (p = 0.003; odds ratio, 1.8). There was no difference in the age of presentation, age at the time of the study, and first or last serum creatinine between children who initially had vesicostomy and children who had ablation.

Conclusions

Ablation of PUV or vesicostomy did not influence kidney function in our study cohort. Children with a normal nadir serum creatinine who presented early had a better outcome.

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Titel: Renal impairment in children with posterior urethral valves
verfasst von: Jameela Abdulaziz Kari
Sherif El-Desoky
Youssef Farag
Hisham Mosli
Abdul-Malik Altyieb
Ahmad Al Sayad
Othman Radawi
Hosam Ghabra
Faten Basnawi
Ohood Bahrawi
Ajay Singh
Hassan Farsi
Publikationsdatum: 01.06.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 6/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2390-7

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Renal impairment in children with posterior urethral valves