Anzeige
Erschienen in:
01.01.2011 | Original Article—Alimentary Tract
Evaluation of new subclassification of type VI pit pattern for determining the depth and type of invasion of colorectal neoplasm
Erschienen in: Journal of Gastroenterology | Ausgabe 1/2011
Einloggen, um Zugang zu erhaltenAbstract
Background
Colorectal neoplasms with a type VI pit pattern include various lesions, such as adenomas, intramucosal cancers, and submucosal carcinomas.
Methods
We analyzed 96 colorectal neoplasms with a type VI pit pattern and identified six different variants: (1) unclear outline of the pit; (2) irregular margins of the pit; (3) narrowing of the pit; (4) ragged array of the pit; (5) high residual density of the pit; (6) abnormal branching of the pit. We examined the relationship between the appearance of each VI pit pattern and histology, including the depth of invasion.
Results
In univariate logistic regression analysis the unclear outline, irregular margins, and narrowing of the pit were significantly associated with a submucosal (SM) invasion ≥1000 μm (P < 0.01). In multivariate logistic regression analysis, unclear outline of the pit was shown to be the only significant predictor of highly invasive submucosal cancer (odds ratio = 24.20, P < 0.0001). Regarding tumor morphology, the following were significantly associated with an SM invasion ≥1000 μm: in protruded type, ragged array (P = 0.022), irregular margins of the pit (P = 0.011), and unclear outline of the pit (P < 0.01); in flat type, irregular margins of the pit (P < 0.01) and unclear outline of the pit (P < 0.01); and in the depressed type, narrowing of the pit (P = 0.015) and unclear outline of the pit (P < 0.01).
Conclusions
Subclassification of the type VI pit pattern is useful for determining the depth of invasion of colorectal neoplasms.