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Erschienen in:
01.10.2011 | Original Article
Association between cerebrovascular carbon dioxide reactivity and postoperative short-term and long-term cognitive dysfunction in patients with diabetes mellitus
Erschienen in: Journal of Anesthesia | Ausgabe 5/2011
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Purpose
Our intent was to identify whether cerebrovascular CO2 reactivity in diabetic patients is a risk factor for postoperative cognitive dysfunction after coronary artery bypass graft (CABG) surgery.
Methods
One hundred twenty-four diabetic patients undergoing elective CABG were studied and analyzed. Diabetic patients were divided into three groups: normal CO2 reactivity group (above 5%/mmHg), medium CO2 reactivity group (between 5 and 3%/mmHg), or impaired CO2 reactivity group (below 3%/mmHg). After the induction of anesthesia and before the start of surgery, cerebrovascular CO2 reactivity was measured for all patients. Hemodynamic parameters (arterial and jugular venous blood gas values) were measured during cardiopulmonary bypass. All patients underwent a battery of neurological and neuropsychological tests the day before surgery, 7 days after surgery, and 6 months after surgery.
Results
At 7 days, the rate of cognitive dysfunction in the impaired CO2 group was higher than in the other three groups (normal, 30%; medium, 25%; impaired, 57%; *P < 0.01 compared with the other groups). In contrast, at 6 months postoperatively, no significant difference in the rate of cognitive dysfunction was found among the three groups. Age, hypertension, CO2 reactivity, the duration for which jugular venous oxygen saturation (SjvO2) was less than 50%, ascending aorta atherosclerosis, diabetic retinopathy, and insulin therapy were independent predictors of short-term cognitive dysfunction in diabetic patients, and HbA1c, diabetic retinopathy, and insulin therapy were independent predictors of long-term cognitive dysfunction in diabetic patients.
Conclusions
We found that impaired cerebrovascular CO2 reactivity was associated with postoperative short-term cognitive dysfunction in diabetic patients.