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Erschienen in: Acta Diabetologica 2/2015

01.04.2015 | Original Article

The use of continuous glucose monitoring systems in a pediatric population with type 1 diabetes mellitus in real-life settings: the AWeSoMe Study Group experience

verfasst von: M. Rachmiel, Z. Landau, M. Boaz, K. Mazor Aronovitch, N. Loewenthal, M. Ben-Ami, Y. Levy-Shraga, D. Modan-Moses, A. Haim, S. Abiri, O. Pinhas-Hamiel

Erschienen in: Acta Diabetologica | Ausgabe 2/2015

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Abstract

Aims

The aim of the study was (a) to compare annual glycemic control in pediatric patients with type 1 diabetes mellitus (T1DM) who used a healthcare-funded continuous glucose monitoring system (RT-CGMS) to that of those who performed self-monitoring blood glucose (SMBG) only, in a real-life setting, and (b) to define parameters associated with compliance and glycemic control.

Methods

A total of 149 youth with T1DM (52.3 % females), mean age 11.8 ± 3.6 years, and 83 in the CGMS group were followed prospectively for 12 months. Glycemic control parameters and compliance to RT-CGMS were assessed periodically.

Results

Glycemic parameters did not differ significantly between the groups during follow-up periods. The time spent with RT-CGMS decreased and only 38 % used it for more than 75 % of the time during the 12 months (consistent users). Mean HbA1c decreased by 0.27 % in consistent users and increased by 0.21 % among intermittent users (used RT-CGMS less than 75 % of time), p = 0.013. Consistent users were younger 10. 6 ± 4.2 vs. 12.5 ± 3.6, p = 0.07, and had higher frequency of SMBG at baseline, 10.6 ± 4.9 vs. 6.3 ± 2.8, p = 0.011.

Conclusions

The adoption of RT-CGMS was low, even in a healthcare system that funds its use. Caregivers should consider patient characteristics when recommending RT-CGMS use.
Literatur
1.
Zurück zum Zitat Reichard P, Nilsson BY, Rosenqvist U; The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329(5):304–309 Reichard P, Nilsson BY, Rosenqvist U; The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329(5):304–309
2.
Zurück zum Zitat The Diabetes Control and Complications Trial Research Group (1994) Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: diabetes control and complications trial. J Pediatr 125:177–188 The Diabetes Control and Complications Trial Research Group (1994) Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: diabetes control and complications trial. J Pediatr 125:177–188
3.
Zurück zum Zitat Petitti DB, Klingensmith GJ, Bell RA et al (2009) Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth Study. J Pediatr 155:668–672 (e661–663) Petitti DB, Klingensmith GJ, Bell RA et al (2009) Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth Study. J Pediatr 155:668–672 (e661–663)
4.
Zurück zum Zitat Wood JR, Miller KM, Maahs DM et al (2013) Most youth with type 1 diabetes in the T1D exchange clinic registry do not meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes clinical guidelines. Diabetes Care 36(7):2035–2037 Wood JR, Miller KM, Maahs DM et al (2013) Most youth with type 1 diabetes in the T1D exchange clinic registry do not meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes clinical guidelines. Diabetes Care 36(7):2035–2037
5.
Zurück zum Zitat Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA (2012) The T1D exchange clinic registry. J Clin Endocrinol Metab 97:4383–4389CrossRefPubMed Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA (2012) The T1D exchange clinic registry. J Clin Endocrinol Metab 97:4383–4389CrossRefPubMed
6.
Zurück zum Zitat Golicki DT, Golicka D, Groele L, Pankowska E (2008) Continuous glucose monitoring system in children with type 1 diabetes mellitus: a systematic review and meta-analysis. Diabetologia 51:233–240CrossRefPubMed Golicki DT, Golicka D, Groele L, Pankowska E (2008) Continuous glucose monitoring system in children with type 1 diabetes mellitus: a systematic review and meta-analysis. Diabetologia 51:233–240CrossRefPubMed
7.
Zurück zum Zitat Tamborlane WV, Beck RW, Bode BW et al (2008) Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 359:1464–1476CrossRefPubMed Tamborlane WV, Beck RW, Bode BW et al (2008) Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 359:1464–1476CrossRefPubMed
8.
Zurück zum Zitat Norgaard K, Scaramuzza A, Bratina N et al (2013) Routine sensor-augmented pump therapy in type 1 diabetes: the INTERPRET study. Diabetes Technol Ther 15:273–280CrossRefPubMedCentralPubMed Norgaard K, Scaramuzza A, Bratina N et al (2013) Routine sensor-augmented pump therapy in type 1 diabetes: the INTERPRET study. Diabetes Technol Ther 15:273–280CrossRefPubMedCentralPubMed
9.
Zurück zum Zitat Nallamothu BK, Hayward RA, Bates ER (2008) Beyond the randomized clinical trial: the role of effectiveness studies in evaluating cardiovascular therapies. Circulation 118:1294–1303CrossRefPubMed Nallamothu BK, Hayward RA, Bates ER (2008) Beyond the randomized clinical trial: the role of effectiveness studies in evaluating cardiovascular therapies. Circulation 118:1294–1303CrossRefPubMed
10.
Zurück zum Zitat Mortensen HB (2002) Findings from the Hvidore Study Group on childhood diabetes: metabolic control and quality of life. Horm Res 57(Suppl 1):117–120CrossRefPubMed Mortensen HB (2002) Findings from the Hvidore Study Group on childhood diabetes: metabolic control and quality of life. Horm Res 57(Suppl 1):117–120CrossRefPubMed
11.
Zurück zum Zitat Wentholt IM, Hoekstra JB, Devries JH (2007) Continuous glucose monitors: the long-awaited watch dogs? Diabetes Technol Ther 9:399–409CrossRefPubMed Wentholt IM, Hoekstra JB, Devries JH (2007) Continuous glucose monitors: the long-awaited watch dogs? Diabetes Technol Ther 9:399–409CrossRefPubMed
12.
Zurück zum Zitat Cemeroglu AP, Stone R, Kleis L, Racine MS, Postellon DC, Wood MA (2010) Use of a real-time continuous glucose monitoring system in children and young adults on insulin pump therapy: patients’ and caregivers’ perception of benefit. Pediatr Diabetes 11:182–187CrossRefPubMed Cemeroglu AP, Stone R, Kleis L, Racine MS, Postellon DC, Wood MA (2010) Use of a real-time continuous glucose monitoring system in children and young adults on insulin pump therapy: patients’ and caregivers’ perception of benefit. Pediatr Diabetes 11:182–187CrossRefPubMed
13.
Zurück zum Zitat Yeh HC, Brown TT, Maruthur N et al (2012) Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: a systematic review and meta-analysis. Ann Intern Med 157:336–347CrossRefPubMed Yeh HC, Brown TT, Maruthur N et al (2012) Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: a systematic review and meta-analysis. Ann Intern Med 157:336–347CrossRefPubMed
14.
Zurück zum Zitat Mastrototaro J, Welsh JB, Lee S (2010) Practical considerations in the use of real-time continuous glucose monitoring alerts. J Diabetes Sci Technol 4:733–739CrossRefPubMedCentralPubMed Mastrototaro J, Welsh JB, Lee S (2010) Practical considerations in the use of real-time continuous glucose monitoring alerts. J Diabetes Sci Technol 4:733–739CrossRefPubMedCentralPubMed
15.
Zurück zum Zitat Pickup JC, Freeman SC, Sutton AJ (2011) Glycaemic control in type 1 diabetes during real time continuous glucose monitoring compared with self monitoring of blood glucose: meta-analysis of randomised controlled trials using individual patient data. BMJ 343:d3805CrossRefPubMedCentralPubMed Pickup JC, Freeman SC, Sutton AJ (2011) Glycaemic control in type 1 diabetes during real time continuous glucose monitoring compared with self monitoring of blood glucose: meta-analysis of randomised controlled trials using individual patient data. BMJ 343:d3805CrossRefPubMedCentralPubMed
16.
Zurück zum Zitat Langendam M, Luijf YM, Hooft L, Devries JH, Mudde AH, Scholten RJ (2012) Continuous glucose monitoring systems for type 1 diabetes mellitus. Cochrane Database Syst Rev 1:CD008101 Langendam M, Luijf YM, Hooft L, Devries JH, Mudde AH, Scholten RJ (2012) Continuous glucose monitoring systems for type 1 diabetes mellitus. Cochrane Database Syst Rev 1:CD008101
17.
Zurück zum Zitat Beck RW, Buckingham B, Miller K et al (2009) Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes. Diabetes Care 32:1947–1953CrossRefPubMed Beck RW, Buckingham B, Miller K et al (2009) Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes. Diabetes Care 32:1947–1953CrossRefPubMed
18.
Zurück zum Zitat Battelino T, Conget I, Olsen B et al (2012) The use and efficacy of continuous glucose monitoring in type 1 diabetes treated with insulin pump therapy: a randomised controlled trial. Diabetologia 55:3155–3162CrossRefPubMedCentralPubMed Battelino T, Conget I, Olsen B et al (2012) The use and efficacy of continuous glucose monitoring in type 1 diabetes treated with insulin pump therapy: a randomised controlled trial. Diabetologia 55:3155–3162CrossRefPubMedCentralPubMed
Metadaten
Titel
The use of continuous glucose monitoring systems in a pediatric population with type 1 diabetes mellitus in real-life settings: the AWeSoMe Study Group experience
verfasst von
M. Rachmiel
Z. Landau
M. Boaz
K. Mazor Aronovitch
N. Loewenthal
M. Ben-Ami
Y. Levy-Shraga
D. Modan-Moses
A. Haim
S. Abiri
O. Pinhas-Hamiel
Publikationsdatum
01.04.2015
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 2/2015
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-014-0643-6

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